In recent years,combat missions and non-combat missions of the army have been more and more frequent in the highlands.However,the special geographical environment in highlands will cause a series of damage to the human body,especially cardiovascular systems,respiratory system and hematologic systems,which will threaten the health of soldiers and directly affect the combat effectiveness.Platelets (PLT) are important blood cells.Soldiers entering the highlands always occur changes of PLT levels and functions,in which severe cases can lead to thrombotic disease and thrombocytopenic purpura.Nevertheless,the studies about high altitude-associated PLT abnormalities are scarce and the underlying mechanisms are far from elucidated.Therefore,deep investigations into high altitude-associated PLT abnormalities are the essential steps in preventing PLT-associated diseases,searching for effective intervention measures and improving the life quality of soldiers in highlands.In this article,we will summarize the latest research findings and discuss the potential mechanisms underlying high altitude-associated PLT abnormalities.Finally,we expect to provide new insights into the prevention and treatment of high altitude-associated PLT abnormalities.

目的探索低压暴露对血小板减少性紫癜小鼠模型的外周血细胞免疫功能的影响。方法将BALB/c小鼠随机分为常压生理盐水组（对照组）、常压GP-APS组、低压生理盐水组、低压GP-APS组。于第1、2、4、6d小鼠腹腔注射豚鼠抗小鼠血小板抗体（GP-APS）100ul/20g，造成小鼠慢性持续性血小板减少。于首次注射血清后第3、5、7d后杀鼠取血检测血小板数量及T细胞亚群表达。结果低压生理盐水组和低压GP-APS组较对照组，CD3+和CD4+明显减少（P＜0.001），CD8+轻度下降，CD4+/CD8+比值明显减少。低压GP-APS组或低压生理盐水组较常压GP-APS组，CD3+、CD4+明显低下（P＜0.001），而CD8+改变不明显，因此CD4+/CD8+比值明显下降。低压生理盐水组较低压GP-APS组各项细胞免疫指标均无显著差异（P＞0.05）。而低压GP-APS组的血小板减少分别与低压生理盐水组和常压GP-APS组之间有统计学差异（P＜0.05）。结论高原血小板减少性紫癜小鼠的血小板减少与低氧和细胞免疫功能异常存在一定的关系，而低压暴露对不同免疫状态小鼠的血小板有明显的影响，但细胞免疫损伤可能无叠加效应。