Objective To observe the safety of a commercially available radiofrequency home beauty instrument with intelligent adjustment of heating energy. Methods From May to September 2022, 121 female subjects aged 30-50 years old with healthy skin in China were recruited from 7 cities and 10 tertiary hospitals in China. All subjects used a double-effect intelligent radiofrequency home beauty instrument (with official gel) in the facial and periocular areas, 5 times a week for 4 weeks. Follow-up was performed at W0, W2 and W4 to observe whether the subjects had adverse reactions such as erythema, edema, papules and blisters, and to evaluate the safety of the product. Results One of the subjects withdrew for other reasons, and the remaining 120 subjects completed the test as required. A small number of subjects had mild local stimulation, and the follow-up symptoms disappeared after the use method was adjusted or not adjusted, which did not affect the continued application of the product. No adverse reactions affecting the use of the product occurred during the treatment of all subjects. Conclusion The clinical application of this radiofrequency home beauty instrument is safe.

目的:探讨用厄贝沙坦联合恩格列净治疗糖尿病肾病(DKD)的效果及安全性.方法:将上海长征医院收治的80例DKD患者纳入本研究.采用信封法将其分为试验组和对照组.对两组患者均进行常规治疗,在此基础上用厄贝沙坦对对照组患者进行治疗,用厄贝沙坦联合恩格列净对试验组患者进行治疗,然后比较两组患者的疗效及各项临床指标.结果:试验组患者治疗的总有效率高于对照组患者,P<0.05.治疗后,试验组患者血清内皮素(ET)、尿酸(UA)、尿素氮(BUN)、肌酐(Cr)的水平均低于对照组患者,血清白蛋白(ALB)的水平和肾小球滤过率(eGFR)均高于对照组患者,P<0.05.用药后,两组患者不良反应的发生率相比,P>0.05.结论:在对DKD患者进行常规治疗的基础上,用厄贝沙坦联合恩格列净对其进行治疗能显著改善其肾功能,提高其疗效,且用药的安全性较高.

目的:探讨使用辣椒碱软膏联合保湿霜治疗神经性皮炎的效果.方法:选取2018年1月至2020年1月期间上海中医药大学附属岳阳中西医结合医院收治的100例神经性皮炎患者作为研究对象.随机将这些患者分为对照组(n=50)和观察组(n=50).为对照组患者使用辣椒碱软膏进行治疗,为观察组患者使用辣椒碱软膏联合保湿霜进行治疗.然后观察两组患者皮损组织中P物质的水平、临床症状积分、临床体征积分、治疗的效果、病情复发的情况、皮损的面积及临床症状改善的时间.结果:治疗后,观察组患者病情的复发率、皮损组织中P物质的水平、临床症状积分及临床体征积分均低于对照组患者,其治疗的总有效率高于对照组患者,其治疗1周后及治疗2周后的皮损面积均小于对照组患者,其临床症状改善的时间短于对照组患者,P<0.05.结论:使用辣椒碱软膏联合保湿霜治疗神经性皮炎的效果显著,可快速减轻患者的临床症状及体征,减小其皮损的面积,且用药后其病情的复发率较低.