基于网络药理学方法研究益母草治疗心梗的作用机制.采用中药系统药理学数据库及技术平台(TCMSP)根据OB≥30％和DL≥0.18的条件筛选出益母草中的化学成分及相关作用靶点,通过Uniprot数据库找出官方基因名称.利用疾病靶点相关数据库检索与心梗相关的靶点基因.将活性成分所对应的靶点基因和心梗相关的靶点基因交集,获得两者的共同基因即为益母草治疗心梗的关键靶点.使用Cytoscape软件构建中药-活性成分-关键靶点网络,根据度值进行筛选,寻找益母草治疗心梗的主要物质基础.将关键靶点导入String数据库获得蛋白互作关系,结果导入Cytoscape软件进行可视化.利用DAVID数据库及ClueGo插件对关键作用靶点进行GO注释分析和KEGG通路分析,探究益母草治疗心梗的生物过程及作用通路.

目的:评估天麻素联合丹参医治椎-基底动脉供血不足的疗效和安全性.方法:检索数据库,搜集天麻素联合丹参治疗椎-基底动脉供血不足的随机对照实验研究,Meta分析和评价.结果:纳入5篇文献,10项研究,523例椎-基底动脉供血不足患者,Meta分析表明,椎--基底供血不足患者用天麻素和丹参联合治疗,有效率和总有效率之间的差异在统计学上显著[RR=1.40,95％CL(1.19,1.63)和RR=1.23,95％CL(1.14,1.32)].结论:天麻素联用丹参注射液治疗椎-基动脉供血不足的效果好于丹参注射液并且安全性高.

Objective: To discuss the effects of hot compress with medicine based on syndrome differentiation by Zhao Hua-nan in promoting the maturity of the autogenous internal arteriovenous fistula. Methods: 60 cases with hematodialysis prepared to receive arteriovenous fistula surgery were randomized into observation group and control group,with 30 cases in each group. Control group were performed hot compress with hot towel 5 days before the surgery and applied with Hirudoid from the second day after the surgery while observation group were performed hot compress with Qi-Benifiting,Blood-Activating and Collateral-Dredging Formula 5 days before the surgery and local hot compress of Chinese medicine with effects of clearing heat,removing toxicity,activating blood and dredging collaterals from the second day after the surgery. The obstruction improvement of the arteriovenous fistula,the first use time for internal fistula and the blood volume of the internal fistula in both groups one month after the surgery were observed. Results: Observation group were better than control group in the aspects of obstruction improvement of the arteriovenous fistula,the first use time for internal fistula and the blood volume of the internal fistula; the difference was significant( P 0. 05). Conclusion: The local hot compress of medicine based on syndrome differentiation by Zhao Hua-nan can improve the blood flow volume of the patients with hematodialysis and promote the development and maturity of the fistula.

目的:探讨采用自制黄连膏治疗烧伤患者对患者血瘀证的影响作用.方法:自2013年1月至2014年12月本院烧伤整形外科共收治早期烧伤患者82例,采用随机数字表法分为常规治疗组和中药组各41例,常规治疗组采用烧伤常规疗法,中药组加用自制黄连膏治疗,比较两组患者治疗前、治疗后第5d的凝血及血液流变学指标差异,同时观察两组患者的烧伤愈合情况.结果:治疗前中药组和常规组的全血低切粘度、全血高切黏度、血浆粘度、红细胞聚集指数、红细胞变形指数测定值比较差异均不显著(P＞0.05);治疗5d后,两组患者的全血低切粘度、全血高切黏度、血浆粘度、红细胞聚集指数、红细胞变形指数较治疗前均显著缩小(P＜0.05),治疗后研究组的上述指标均显著小于常规组(P＜0.05).治疗前两组患者的APTT、AT-Ⅲ:Ag、PC:a测定值比较差异不显著(P＞0.05),治疗后两组患者的APTT、AT-Ⅲ:Ag、PC:a测定值较治疗前均显著升高(P＜0.05),中药组升高较常规组更加显著(P＜0.05).中药组的水肿消退时间4.4±1.8(d)、创面愈合率77.9±9.4(％)、创面愈合时间7.8±2.1(d)、创面感染率4.88(％)均显著的低于常规组(P＜0.05).中药组的总有效率达到95.12％显著高于常规组的78.05％(P＜0.05).结论:自制黄连膏治疗烧伤血瘀症患者能够显著改善患者的高凝血状态及血液流变学指标,从而提高创面愈合效果.

Professor Zhao in treating chronic renal insufficiency taking visceral syndrome differentiation as guidelines,he considered that the onset base on spleen and kidney deficiency,phlegm stasis cross resistance,intermingled deficiency and excess is the pathogenesis.Therefore,supporting the healthy energy is the fundamental method of treatment of this disease. In addition,Professor Zhao usually used promoting blood circulation to remove blood stasis drugs and purging turbidity and detoxification medicine according to syndrome differentiation of Qi-blood and excess-deficiency. Professor Zhao combination of syndrome differentiation and disease differentiation in clinical,administration to be flexible,hot packs of Chinese medicine according to syndrome differentiation,and improve the prognosis,so as to achieve good clinical efficacy.