Objective:To explore the characteristic of cognitive flexibility in young female patients with eating disorders（EDs）,including anorexia nervosa（AN） and bulimia nervosa（BN）,and its relationship with the clinical features of ED.Methods:Ninety-two young female patients with EDs, including 28 patients with AN and 64 patients with BN,and 38 normal controls were enrolled.Cognitive flexibility was assessed with percentage of persistent errors（PPE） and percentage of persistent responses（PPR） of the Wisconsin Card Sorting Test（WCST）,and clinical features of ED by using the Eating Disorder Inventory-1（EDI-1）.Results:The PPE[（5.0±4.7）% vs.（2.8±2.8）%,P＜0.01]and PPR[（11.7±7.8）% vs.（6.4±5.9）%,P＜0.001]were higher in ED group than in normal control group, but the differences on PPE[（5.5±5.4）% vs.（5.0±4.5）%,P＞0.05]and PPR[（11.2±7.8）% vs.（11.1±7.3）%,P＞0.05]between AN and BN groups were not statistically significant.The PPE（r=0.21,P＜0.05） and PPR（r=0.27,P＜0.01） were positively correlated with the EDI-1 total scores.PPR was positively correlated with the frequency of appetite suppressant use（r=0.28,P＜0.05） and skipping several meals（r=0.30,P＜0.01） in the ED group.Conclusion:The presence of cognitive flexibility deficits in young female patients with eating disorders, and their correlation with clinical features of eating disorders further support the possibility of being an endophenotype of eating disorders.

Objective:To investigate resting-state regional homogeneity in patients with bipolar disorder in different mood states and the potential trait imaging markers of bipolar disorder.Methods:This is a cross-sectional study involving 169 patients who met the diagnosis criteria of bipolar disorder in DSM-Ⅳ-TR (including 68 patients with bipolar depression, 29 patients with bipolar (hypo)mania, 72 patients with bipolar euthymia) and 113 controls matched by age and gender. The severity of depression, mania, and the positive and negative affects were assessed by the Hamilton Depression Scale (HAMD 17), Young Mania Rating Scale (YMRS), and Positive and Negative Affect Schedule (PANAS). Resting-state fMRI data were obtained. After fMRI data processing, 64 patients with bipolar depression, 28 patients with bipolar (hypo)mania, 66 patients with bipolar euthymia, and 112 controls were included in the final analysis. The regional homogeneity (ReHo) values were computed, and analysis of covariance was performed on ReHo values among the four groups. Post hoc analysis was conducted based on the ReHo values extracted from the brain regions with significant differences. The relationship between the ReHo values and clinical scores was examined. Results:Significant ReHo differences were observed in the bilateral posterior cerebellum ( F=11.41 for left, F=10.45 for right), bilateral calcarine cortex ( F=10.60 for left, F=9.59 for right), and right superior temporal gyrus ( F=10.58). Compared to controls, bipolar patients in all mood states demonstrated decreased ReHo in the left posterior cerebellum ( P<0.01 for all) and increased ReHo in the right posterior cerebellum ( P<0.05 for all), bilateral calcarine cortex and right superior temporal gyrus ( P<0.01 for all). The clinical score of negative affects was negatively correlated with the ReHo values in the right calcarine cortex ( r=-0.17, P=0.04, uncorrected). Conclusions:Bipolar disorder is characterized by regional homogeneity changes in the bilateral posterior cerebellum, bilateral calcarine cortex and right superior temporal gyrus across different mood states. The functional abnormalities in the cerebellum, visual network and sensorimotor network could comprise a trait biomarker for bipolar disorder.

厌食症是心身疾病 作为从事进食障碍诊疗的精神科医生,我经常听到患者说上面这些话.这些说法都反映出大家对厌食症的误解. 先来了解一下进食障碍,这是一组以进食态度和进食行为异常为表现的心身疾病.进食障碍患者虽然表现为进食行为异常,但却没有口腔或胃肠道疾病的生理原因,病因的核心在心理层面.

随着我国社区卫生资源的逐渐完善，包括抑郁症在内的许多疾病在社区层面得以被及时发现和早期干预。2021年刊出的《抑郁症基层诊疗指南（2021年）》，从定义、分类、诊断、药物治疗、转诊、疾病管理等方面进行了重点介绍，以帮助基层医疗卫生工作者更好地开展抑郁症识别和处理。本文是该指南的延伸内容，介绍抑郁症的重要补充治疗方法——运动疗法，该方法特别适合在社区层面开展实施，能够促进抑郁症患者康复，并预防复发。

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">&lt;正&gt;随着新型冠状病毒（novel coronavirus,2019-nCoV）感染肺炎疫情不断升级,影响人们生活的不仅是病毒,还有恐慌。无论是身处飓风的中心,还是外围防守,多数人神经紧绷,时刻关注着疫情的最新情况。尤其是疑似患者人群,在意识到灾难和危险来临时,通常都会出现恐慌、沮丧等负性情绪,甚至采取极端行为对自己造成进一步伤害。面对疫情,疑似患者人群可以做什么?我们精神心理工作者为疑似患者提出几点建议。1 对疾病正确的认知焦虑常常</span>

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的:初步探讨女性神经性厌食（anorexia nervosa,AN）患者不同亚型,即限制型（anorexia nervosa restricting type,ANR）和暴食/清除型（anorexia nervosa binge-purging type,ANBP）临床及心理特征的差异。方法:采用进食障碍问卷（eating disorder questionnaire,EDQ）及进食障碍调查量表-1（eating disorders inventory-1,EDI-1）,对269例ANR和151例ANBP女性AN患者进行横断面调查。对其人口学资料、体质量指数（body mass index,BMI）、EDI-1量表因子分进行比较;采用logistics回归分析,探讨可能影响AN分型的因素。结果:ANBP组当前BMI高于ANR组,但其期望的BMI却低于ANR组。ANBP组EDI-1总分及各因子分均高于ANR组。Logistics回归显示暴食、无效感分值越高,越倾向于ANBP亚型;成熟恐惧分值越高,越倾向于ANR亚型。结论:暴食、无效感、成熟恐惧对女性AN的诊断分型具有预测作用;ANBP与ANR亚型可能具有不同的心理特征。</span>

Objective To examine the chagnes of functional network modularity in treating-na6ve,first episode major depressive disorder（MDD）patients and the relationship between modularity related indicators and clinical severity.Methods 50 na6ve,the first episode patients with

Objective To explore the differences of prodromal symptoms between bipolar disorder (BD) and recurrent major depressive disorder (RMDD).Methods We used the Bipolar Prodrome Symptom Interview and Scale-Retrospective to investigate 74 BD patients and 37 RMDD patients,which included open questions and semi-structured questions about the 39 prodromal symptoms to the first full depressive episode.Results (1) Most of BD patients (91.9％,68/74) and RMDD patients (97.3％,36/37) could recognize their prodromal symptoms.(2) BD patients reported more psychotic symptoms than RMDD patients (t=-3.761,P=0.001).(3) Compared with RMDD patients,more BD patients reported prodromal symptoms,overly cheerful/happy/on top of the world(16 cases (21.6％,16/74) vs.2 cases (5.4％,2/37),x2=5.269,P=0.022),overly talkative (19 cases (25.7％,19/74) vs.3 cases (8.1％,3/37),x2=5.370,P=0.020),racing thoughts or jumping from one thought to another (17 cases (23.0％,17/74) vs.3 cases (8.1％,3/37),x2=4.168,P=0.041),extremely energetic or active (18 cases (24.3％,18/74) vs.1 cases (2.7％,1/37),x2=8.777,P=0.003),overly self confident (14 cases (18.9％,17/74)vs.0,x2=8.514,P=0.002),and frequent mood swings/lability (38 cases (51.4％,38/74) vs.8 cases (24.3％,8/37),x2=10.537,P=0.001),and these symptoms were more likely to be a part of the bipolar prodromal symptoms.Conclusions BD patients and RMDD patients represent different prodromal symptoms,which could promote early identification and early intervention of BD.