Objective:To investigate the reliability and validity of the Chinese Version of Dimensional Anhedonia Rating Scale (DARS).Methods:136 subjects who were diagnosed with depressive disorder and 30 healthy controls were selected to complete the Chinese version of DARS, Hamilton Depression Scale (HAMD 17), and Hospital Anxiety and Depression Scale (HADS). Cronbach’s alpha coefficient, test-retest reliability and confirmatory factor analysis were conducted. HADS and HAMD 17 were considered as the gold standard to investigate the criterion validity of the Chinese version of DARS. Results:The Cronbach’s α of the Chinese version of DARS was 0.97, the coefficient of the four domains ranged from 0.89 to 0.96. The intraclass correlation coefficient ( ICC) of test-retest reliability was 0.97， ICC of four domains ranged from 0.89 to 0.95 ( P<0.01)．The results of confirmation factor analysis of the Chinese version of DARS were as followed: χ 2/ df=2.02, GFI=0.88, RMSEA=0.08, CFI=0.96, and TLI=0.96. Validity: The total score and four domains of the Chinese version of DARS were significantly correlated with the seventh item of HAMD ( r=-0.38- -0.52, P<0.01) and all five items of HADS score ( r=-0.57- -0.75, P<0.01). There was significant difference between depression group and health control group. Conclusion:The Chinese version of DARS has good psychometric properties with adequate reliability and validity, and could be applied to assess the anhedonia of depression in China.

Objective To explore the changes of functional connectivity patterns of dorsolateral prefrontal cortex(DLPFC)related to emotion management in patients with bipolar Ⅱdepression under the resting state. Methods The general demographic and clinical data of 30 patients with bipolar Ⅱdepression and gender-and age-matched healthy controls were collected.All subjects completed the resting-state functional magnetic resonance scans. After the imaging preprocessing, seed- based functional connectivity analysis was performed on the bilateral DLPFC using REST software.The single sample t test was used to analyze the connection distribution pattern of each DLPFC region of interest in the group.The independent sample t test was used to compare the differences between two groups of DLPFC functional connections with age and sex covariate.Subsequently,Pearson correlation analysis was performed between the mean connectivity values of regions showing significant group differences and depressive severity (HAMD17scores). Results Compared with healthy controls, patients with bipolar Ⅱ depression showed abnormally increased functional connectivity between the left DLPFC seed and the right superior medial frontal gyrus, left superior, middle, inferior temporal gyri, right superior temporal gyrus and right parahippocampal gyrus(t=4.809,4.689,4.912;all P<0.05), while the functional connectivity was abnormally decreased between the left DLPFC and the left inferior parietal lobule, left superior medial frontal gyrus(t=-4.065,4.625; both P<0.05). The right DLPFC showed abnormally reduced functional connectivity with the right middle frontal gyrus(MNI:x=42,y=36,z=30;t=-5.093,P<0.05)and the right inferior frontal gyrus(MNI:x=6,y=21,z=45;t=-4.553,P<0.05). No significant correlations were found between the mean connectivity values of the regions showing significant group differences and depressive severity (HAMD17scores). Conclusion The results suggest that patients with bipolar Ⅱ depression have altered resting state functional connectivity in the bilateral DLPFC, which may be a biological basis for abnormal emotion management of bipolar Ⅱ depression patient. Its specificity still needs to be compared with other related diseases.

Objective To study the relationship between cognitive impairment and white matter lesions in bipolar disorder (BD) type I in stable period patients. Method A total of 68 consecutives as BD type I in stable period patients were enrolled in the observation group and other 60 healthy persons in the control group;Then to compare cognitive impairment by digit symbol test, digit span test, visual reproduction test, trail making test, verbal fluency test, Wisconsin card sorting test-modified and tower of Hanoi, the white matter lesions by diffusion tensor imaging. Results The cognitive impairment by the seven tests were all worse in observation group than control group (P<0.05).The FA values of corpus callosum, temporal lobe and basal ganglia in observation group were all significantly lower, while ADC values correspondingly higher (P<0.05).But those of frontal lobe, occipital lobe and cerebellum were no statistical differences between the two groups (P>0.05). Conclusion The patients with BD type I in stable period have cognitive impairment in a certain extent, which may be related to white matter lesions of corpus callosum, temporal lobe and basal ganglia.

Objective To examine the chagnes of functional network modularity in treating-na6ve,first episode major depressive disorder（MDD）patients and the relationship between modularity related indicators and clinical severity.Methods 50 na6ve,the first episode patients with