临界肺动脉高压(bPH)是介于正常肺动脉压力和(或)阻力与肺动脉高压(PH)诊断标准之间的肺动脉血流动力学状态,是一个被长期忽略的"灰色地带".近年来,随着PH领域临床研究及诊治水平的进展,循证医学证据提示,bPH不仅是PH发生发展的前期阶段,也与患者的再住院率和死亡率息息相关.但目前现有国内外指南对bPH依然缺少统一的诊断标准和治疗方案.分析和了解近年来bPH的诊治进展,剖析bPH诊治仍存在的问题,对尽早控制PH患者病情、降低死亡率和提高长期预后具有重要意义.

Chronic obstructive pulmonary disease (COPD) is a very common, preventable and treatable disease of the respiratory system.Its main characteristics are persistent respiratory symptoms and airflow limitation.COPD is a systemic disease, often accompanied by a variety of complications, including malnutrition, osteoporosis, metabolic syndrome, etc.And there are many prognostic factors, including age, body mass index, severity of inflammation, and comorbidities.Recent many studies find that uric acid plays an important role in the development and prognosis of COPD.Serum uric acid is the end product of purine metabolism and is closely related to COPD.It is involved in a variety of pathophysiological processes, such as oxidation-antioxidation, inflammation, and malnutrition, osteoporosis, etc.These diseases include various systems, such as kidney disease, liver disease, diabetes, cardiovascular and cerebrovascular diseases, etc.The respiratory system diseases mainly include COPD, asthma, pulmonary fibrosis, obstructive sleep apnea, hypopnea syndrome, lung infection, lung cancer, etc.This article mainly elaborates the correlation between uric acid and the prognostic factors of COPD.