Objective To investigate the effect of Simoyinzi Decoction on serum 5-HT and inflammatory factors in the treatment of perimenopausal women with early onset of severe depression.Methods 82 cases of perimenopausal women with primary severe depression were selected and randomly divided into 2 groups, 41 cases of each group.Control group received basic medicine treatment, the research group received Simoyinzi Decoction treatment,serum neurotransmitter, inflammatory factor and sex hormone levels were detected before and after the treatment, and clinical symptom score and clinical curative effect were compared after the treatment.Results Compared with before treatment, levels of noradrenaline norepinephrine(NE), 5 serotonin(5-HT), dopamine(DA), glutamate(Glu) and N-methyl-D-aspartate(Asp) increased in 2 groups after treatment, levels of gamma amino acid (GABA) and glycine(Gly) decreased, levels of follicle stimulating hormone(FSH) and luteinizing hormone(LH) decreased, levels of estradiol(E2) increased, levels of IL-1β, IL-6, TNF-αand CRP decreased, scores of HAMD and Kupperman decreased, the differences were statistically significant (P<0.05), compared with the control group, levels of NE, 5-HT, Glu and Asp in the research group after treatment were higher, levels of GABA and Gly were lower, levels of FSH and LH were lower, levels of E2 were higher, levels of IL-1β, IL-6, TNF-αand CRP were lower, and scores of HAMD and Kupperman were lower, the differences were statistically significant(P<0.05), and the effective rate in the control group(70.73%) was lower than the research group ( 90.24%) ( P <0.05 ) .Conclusion Simoyinzi Decoction in the treatment of perimenopausal women with early onset of severe depression was curative effective, and it can improve the 5-HT and reduce the levels of inflammatory factors.

目的 对血液检验标本出现误差的原因进行分析探讨并提出相应的解决对策.方法 回顾性分析2009年5月-2013年5月期间出现血液检验误差的140份标本进行分析,对其产生误差的原因进行分析,并制定相应的解决对策.结果 该140份出现误差的血液标本中有69例是因患者自身因素造成,所占比例为49.28％,由样本送检造成的有37例,所占比例为26.43％,由采集因素造成误差的有22例,所占比例为15.71％,由标本检验因素造成检验误差的有12例,所占比例为8.58％.结论 造成血液检验误差出现的因素有很多,因此不能轻视检验过程中的任何一个环节,必须严格按照操作规范进行操作,以降低血液检验误差的出现.

目的：观察肠炎宁胶囊治疗慢性溃疡性结肠炎的临床疗效。方法：治疗组81例用柳氮磺吡啶＋肠炎宁胶囊治疗，对照组76例柳氮磺吡啶常规治疗，均以4周为1个疗程，并观察2个疗程后的疗效。结果：治疗组治愈率、总有效率明显优于对照组（P＜0．05），内镜下溃疡好转明显优于对照组，且未发生不良反应。结论：肠炎宁对治疗慢性溃疡性结肠炎有显著疗效。

目的 应用受试者工作特征曲线(Receiver operating characteristics,ROC)分析死亡诱骗受体3(Death decoy receptor 3,DcR3)对类风湿性关节炎(Rheumatoid Arthritis,RA)的诊断价值.方法 用亲和素放大的酶联免疫吸附试验(ELISA)检测33例RA患者、10例硬化征患者及16例正常对照组血清可溶性DcR3浓度,分析不同组间DcR3表达的差异,以及RA患者DcR3与各临床指标的相关性.采用ROC曲线,评价DcR3对RA的诊断效能.结果 RA患者DcR3水平显著高于正常对照组(U =158.00,P＜0.05),与硬化征组比较差异无统计学意义(U =121.50,P＞0.05).RA患者DcR3水平与不同疾病分期(X线分期)、性别、年龄及各临床指标相关性差异无统计学意义(P＞0.05).通过ROC曲线分析,用DcR3诊断RA的曲线下面积(Area under the ROC curve)为0.701,曲线下95％可信区间(Asymptotic 95％ Confidence Interval)为0.553～0.849.最佳临界点为213 pg/ml,敏感度为51.5％,特异性为81.2％;阳性似然比为2.75,阴性似然比为0.60.结论 RA患者血清可溶性DcR3高表达,对RA具有良好的诊断价值.

Objective To observe the alteration of platelet activation factor(PAF) and von Willebrand factor(vWF) in patients with unstable angina pectoris(UAP) accepting Ginkgo Biloba tablet treatment,and to explore its mechanism of protection efficacy of cardiovascular diseases.Methods The levels of PAF,vWF and PAR were measured in 26 healthy controls and 61 patients with unstable angina pectoris(UAP).The patients were randomly assigned into routine treatment group(control group) and combinating Ginkgo Biloba tablet treatment group(Ginkgo Biloba group).Before treatment and after 20 days of treatment,the levels of PAF,vWF and PAR were measured,respectively.Results At group UAP,levels of PAF,vWF and PAR were remarkably higher than those at healthy control group(P 0.01).Before treatment,there was no significant difference for the three indicators between control group and Ginkgo Biloba group.In Ginkgo Biloba group,the levels of PAF,vWF and PAR after 2 days of treatment were significantly lower than those before treatment(P 0.01),but in control group,levels of the three indicators showed less difference between after and before treatment(P 0.05).Conclusion There is obvious efficacy of Ginkgo Biloba tablet on unstable angina pectoris.The efficacy is attributable to paltelet aggregation rate decreasing via down-regulating the levels of platelet activation factor and von Willebrand factor.

<正>失眠是指患者对睡眠时间和(或)睡眠质量不满足并影响其白天社会功能的一种主观体验[1]。轻者可使患者白天出现嗜睡、头昏、精神不振和乏力等不适,严重时还可影响老年人其他疾病的治疗和康复[2]。据全国失眠调查显