慢性心力衰竭(chronic heart failure,CHF)是由结构或功能性心脏疾病导致心室充盈或射血功能受损进而引起的一组综合征.中医药治疗CHF具有多组分、多途径、多靶点的特征,因此笔者通过对近年来常用中药单体、中药复方和中成药治疗CHF的作用通路、靶点等方面加以总结,发现多种中药单体、中药复方和中成药可通过抗纤维化、抗炎、抗氧化、促血管生成、抗凋亡、调节线粒体和能量代谢、抑制肾素-血管紧张素-醛固酮系统(RAAS)等途径发挥治疗作用.

类风湿关节炎(RA)的发生发展与丝裂原活化蛋白激酶(MAPK)信号通路密切相关.综述近年来的研究概况,发现多种中药提取物及有效部位、中药复方及中医物理治疗可通过调控MAPK通路,抑制促炎因子及基质金属蛋白酶(MMP)的释放,改善RA滑膜炎症及骨破坏.

本研究探讨了周亚滨教授对缓慢性心律失常的认识及临证用药特点,初步总结周亚滨教授治疗缓慢性心律失常的临证经验.周教授认为本病多本虚标实证,辨证从辨虚实、辨病因、辨脉象等方面着手.益气温阳、活血化瘀通络、养心安神为主要治法.周教授对本病的诊疗思路缜密,临床收效显著,对本病的诊治经验值得交流学习.

目的:观察艾灸隔大黄贴预防榄香烯注射液所致静脉炎的临床疗效.方法:将80例患者随机分为观察组与对照组,每组各40例,观察组自静脉滴注榄香烯注射液首日开始,采用艾条隔大黄贴温和灸,对照组暂不处置,两组患者发生静脉炎后,均给予硫酸镁湿敷,14天为一疗程.比较两组静脉炎发生率、发生时间与程度、彩色多普勒血流成像及D-二聚体改变情况.结果:观察组与对照组静脉炎发生率分别为50％与95％,两组比较P＜0.01;观察组静脉炎发生时间与程度均明显低于对照组(P＜0.05);观察组彩色多普勒血流成像减弱、消失例数分别为15、2,明显低于对照组的24、4(P＜0.05);观察组D-二聚体升高例数程度明显低于对照组(P＜0.05).结论:艾灸隔大黄贴可有效预防榄香烯注射液所致静脉炎.

Objective To observe the effect of elemene injection for the maintenance treatment of malignant pleural effusion.Methods A total of 90 patients with malignant pleural effusion from May 2014 to Apirl 2016 in First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were collected.They were divided into observation group (n =45) and control group (n =45) according to the random number table method.The patients of the two groups were treated with pleural effusion drainage through thoracocentesis,and Mannatide (Lifein) and carboplatin were poured.The observation group sequentially received maintenance treatment of elemene injection.The therapeutic effects of the two groups were compared.Results At the 12th month after treatment,the difference of relapse rate between the two groups was statistically significant(82.2％ vs.100.0％,x2 =8.780,P =0.003).The median progression-free survival (95％ CI) of the observation group and the control group were 10.00 (9.15-10.85) months and 6.00(4.74-7.26) months respectively,with a significant difference (x2 =40.475,P ＜ 0.001).The improvement rates of life quality of the observation group were 82.22％,57.78％,54.55％ respectively at one,six,twelve months after perfusion treatment,and the improvement rates of the control group were 84.44％,23.26％,0 respectively.The data differences between the two groups were statistically significant at six,twelve months (x2 =10.840,P =0.001;x2 =32.390,P ＜ 0.001).The one year survival rates of the observation group and the control group were 97.78％ and 95.56％,and the difference was statistically significant (P =1.000).Conclusion The effect of elemene injection for the maintenance treatment of malignant pleural effusion is obvious,which can prolong the progression-free survival time and can significantly improve the quality of life.