Objective To study the protective effects and mechanism of Asiatic Acid (AA ) on traumatic brain injury . Methods The closed craniocerebral injury model made by the weight-drop method and fluid percussion brain injury model were used in the study .Brain water content ,blood brain barrier permeability and brain tissue pathology morphology were measured to study the neuroprotective effect of AA on traumatic brain injury .Moreover ,the inflammatory cytokines such as TNF-α,IL-β,IL-6 were examined by PCR and ELISA to study the mechanism of AA .Results Brain water content and permeability of blood brain barrier were significantly decreased ,the traumatic brain injury was nameliorated by AA .Moreover ,the expressions of inflammatory cytokines TNF-α,IL-β,IL-6 were inhibited by AA .Conclusion AA has the protective effects on traumatic brain injury and the mechanism is related to the anti-inflammatory effect .

目的：该研究主要探究早发2型糖尿病的临床特点以及相关危险因素。方法选取该院于2012年6月—2014年6月期间收治的早发2型糖尿病患者170例，对其临床资料进行分析，主要分析的内容有颈围、腰围、体质指数、丙氨酸转氨酶、三酰甘油、肝肾功能、尿微量白蛋白水平等。最后探究糖尿病的临床特点以及相关危险因素。结果经过对患者的资料进行分析，所有患者中合并NAFLD者共有98例，合并高尿酸血症的有28例，合并CIMT增厚者共有50例，所占比例分别为57.6%、16.5%和29.4%；各组间的体质指数、颈围、腰围、丙氨酸转氨酶、三酰甘油的水平的差异有统计学意义(P<0.05)；经过多因素非条件logistic分析，颈围、腰围、体质指数、丙氨酸转氨酶是NAFLD以及CIMT增厚的共同危险因素。结论早发2型糖尿病确诊时绝大多数患者已有多种代谢异常；NAFLD、高尿酸血症、颈围增大及CIMT增厚不仅互为危险因素，而且颈围和血尿酸水平等是NAFLD和CIMT增厚的共同危险因素。