Objective To explore clinical significance of Pre-S2 antigen in inapparent and apparent hepatitis B virus infections.Methods Pre-S2 antigen and HBV serum markers of inapparent and apparent hepatitis B virus infection cases were detected by enzyme linked immunosorbent assay.Results In cases with inapparent hepatitis B virus infection,co-positive rate of Pre-S2 antigen and HBeAg was 93.10%,and of Pre-S2 antigen and HBeAb was 60.00%.The positive rates of Pre-S2 antigen in people with positive HBsAg,HBcAB and people with positive HBsAg,HBeAb,HBcAg were 92.31% and 62.50%,respectively.While the positive rates of Pre-S2 antigen in acute and chronic hepatitis B patients were 90.91% and 61.54% respectively.Conclusion Pre-S2 antigen has great significance in detection of mutation and serum infection ability of hepatitis B virus infection cases(especially in inapparent infection cases).Meanwhile,it also has obvious significance in judging changing and clinical outcomes of inapparent hepatitis B patients.

[Objective]To study status and use value of Pre-S2 antigen in hepatitis B virus inapparent or apparent infections(especially inapparent infection).[Methods]Enzyme Linked Immunosorbent Assay was used to detect Pre-S2 antigen and HBV M of the different kinds of hepatitis B virus inapparent and apparent infecters,then compared and analysed them.[Results]64 hepatitis B virus inapparent infecters,their positive rates of Pre-S2 antigen were 64.06%.Among them,HBeAg positive people were 93.10%,HBeAb positive people were 60.00%,HBcAb positive people were 73.47%,and the former was higher than the two latter(P<0.05).People of"Hepatitis B Large-three-positive" and"Small-three-positive",their positive rates of Pre-S2 antigen were 92.31% and 62.50% separately(P<0.05).22 acute hepatitis B patients and 26 chronic hepatitis B patients,their positive rates of Pre-S2 antigen were 90.91% and 61.54% respectively(P<0.05).[Conclusion]Pre-S2 antigen has greater use value and addendum function to judge hepatitis B virus infecters'(especially inapparent infecters') serous infectious strength.It also has important reference significance to judge hepatitis B inapparent infecters' change and apparent infecters' outcome.

Objective To understand the status of hepatitis B virus infection and its changes in various groups of teen-aged students in recent three years.Methods Enzyme linked immunosorbent assay(ELISA)was used to detect HBsAg,HBsAb,HBeAg,HBeAb and HBcAb among 7 605 teen-aged students in Yongzhou City from 2003 to 2005,then the data were analyzed year by year.Results The HBsAg average positive rate was 11.65% during the three years.From 2003 to 2005,the HBsAg positive rates were 10.20%,11.75% and 13.36% respectively.The HBsAg positive rates were 12.10% and 10.28% in boy and girl students respectively,10.92% and 13.16% in town and country students respectively,12.83% and 11.15% in boarding and nonboarding students respectively,and 10.88% and 12.01% in junior and senior middle school students respectively.Among 886 HBsAg positive students,HBeAg positive rate was 61.52%.Conclusions Among teen-aged students,hepatitis B infection rate is not only high,but also increasing in Yongzhou City,and a number of them are strong infectious.Country students,boy students and boarding students should be paid a special attention.

目的:探讨前S2抗原(Pre-S2抗原)与乙型肝炎病毒(HBV)隐、显性感染的关系及其临床意义.方法:采用ELISA法同时检测HBV隐性感染者(为主)及适量显性感染者的Pre-S2抗原和乙肝血清标志物,然后进行各类、群感染者之间的比较和分析.结果:在HBV隐性感染的人群中,e抗原阳性者和e抗体阳性者Pre-S2抗原的阳性率分别为93.10%和60.00%;"乙肝大三阳"者和"小三阳"者Pre-S2抗原的阳性率分别为92.31%和62.50%.在乙肝病毒显性感染者(急、慢性乙肝患者)人群中,Pre-S2抗原的阳性率分别为90.91%和61.54%.结论:Pre-S2抗原在判断感染者尤其是隐性感染者血清的传染性、以及隐性感染者的发展转化和显性感染者的临床转归方面,具有较大的参考价值.

To study status and use value of Pre - S2 antigen in different types of hepatitis B virus' s inapparent infections in scientific reseach and clinical work. Enzyme linked immunosorbent assay was used to detect hepatitis B virus's inapparent infecters' Pre - S2 antigen and HBV M in different classification, then compared and analysed them. In hepatitis B virus s inapparent infecter crowds, positive rates of Pre - S2 antigen were 93.10% and 60.00% respectively to HBeAg positive people and HBeAb positive people. People of " Hepatitis B Large - three - positive" and " Small - three - positive" , their positive rates of Pre - S2 antigen were 92.31% and 62.50% separately. Pre - S2 antigen has greatest use value and addendum function of judge hepatitis B virus' s replication and inapparent infecters serous infectious strength. It also has great reference significance to judge hepatitis B inapparent infecters' change.