目的:分析我院确诊的新型冠状病毒肺炎(COVID-19)患者的流行病学特点、临床特征和治疗结果,为疫情防控提供临床参考.方法:回顾性分析2020年1月20日至2020年4月1日,首都医科大学附属北京安贞医院确诊的6例COVID-19患者的流行病学特征、临床表现、辅助检查结果及治疗后转归.结果:观察期间共有6例疑似患者分别经朝阳区和北京市疾控中心病毒实验室核酸检测证实为COVID-19确诊病例,占同期疑似患者的15％(6/40).6例患者(4例男性,2例女性)平均年龄54岁,4例有明确武汉旅游或居住史,1例有与COVID-19确诊患者密切接触史,1例无明确流行病学史.发病平均潜伏期2.3d.6例患者均有发烧和肌肉酸痛、4例咳嗽、2例咽痛.血常规检查WBC总数均正常,1例淋巴细胞计数降低.所有患者流感筛查均阴性.4例患者血hs-CRP反应蛋白水平升高.6例患者均接受胸X线片检查,其中5例回报正常,1例胸X线片显示:双侧肺炎性表现,后经胸部CT扫描证实双肺渗出和磨玻璃影;1例胸X线片未回报异常但CT检查显示双肺磨玻璃表现.综合临床表现和影像学,4例患者诊断为轻型,2例为普通型.6例患者均转定点医院住院治疗并康复出院,平均住院时间为19.7 d.结论:早期COVID-19患者绝大多数有武汉旅游史或与确诊COVID-19患者密切接触;发热、咳嗽和肌肉酸痛为主要症状;本研究患者全部为轻型或普通型,经早发现、早诊断、早隔离和早治疗,预后良好.

Objective:To investigate the clinical features,diagnosis and prognosis of influencza A(H1N1) virus infection in 2009.Methods:The clinical data of 98 patients with influenza A(H1N1) admitted into Beijing Anzhen Hospital Affiliated to Capital Medical University and 5 critically ill patients with same diseases in other hospitals from August 2009 to January 2010 were retrospectively analyzed,and related literatures were reviewed.Results:In the group of cases,the average age was(31.06±13.43) years,and the main clinical manifestations presented fever(100%),cough(88.3%) and chill(81.6%),etc.The mortality rate of severe and critically ill patients was 22.2%.The most common complications was bacterial infection and acute respiratory distress syndrome as well as multively.Organ dysfunction syndrome,and the incidences was 85.7%,57.1% and 28.6%,respectively there was significant relation between chronic underlying diseases and presence of severe cases.Conclusion:The influenza A(H1N1) often occur in young adults,main clinical characteristics present respiratory tract symptoms.In severe cases,there may be double infection,coagulation disorder,respiratory alkalosis and hypoxemia or respiratory failure,which happen easily in existence of chronic underlying diseases.

人工血管感染是血管外科严重的并发症之一,发生率约为1%～6%,病死率及截肢率较高.对于不同部位、不同病原菌所造成的感染处理方法不尽相同,传统的方法包括局部清创、切除感染的人工血管、经解剖外途径血管重建以及内科保守治疗.现报道1例.

近年文献报道,血清补体C3d对细菌感染性疾病诊断的敏感性优于C反应蛋白和中性粒细胞计数等指标[1].为此,本文对63例肺炎患儿进行了补体C3d的测定,并与集落细胞刺激因子(G-CSF)及中性粒细胞计数(NC)相比较,以观察其在感染性疾病病原诊断中的价值.