We evaluated the effect of eiconol containing polyunsaturated fatty acids on the behavior and alcohol motivation in rats. Administration of eiconol for 10 days to alcoholized rats against the background of ethanol deprivation produced a sustained suppression of alcohol motivation and corrected deprivation-specific behavior.

The effects of eikonol, a preparation containing polyunsaturated fatty acids omega-6/omega-3 in a ratio close to the optimal for humans, were tested in a psychophysiological study involving 42 subjects. A dietary vegetable oil served as control. In the sensorimotor testing of the operational, type, the subjects were supposed to memorize three reference two-digit numbers during a short time so as to decide on presentation of the test number whether the latter was present among the reference numbers. The subject was presented 480 test samples with randomly selected numbers before and after the intake of eikonol. The course of eikonol for 30 days exerted a statistically significant positive effect on all the subjects. Individual features in the subjects’, response to eikonol were noted, i.e., in about 50% of them, the effect of eikonol was manifested by only a decreased number of wrong answers, whereas, in the rest of subjects, this effect was observed simultaneously with an increased number of right answers. As compared with the effects of the oil, the positive effect of eikonol on the parameters of operational activity of humans appeared to be much more pronounced and affected twice as many subjects tested. Possible prospects of the use of eikonol for optimization of cognitive processes in humans with an individual selection of the dosage and regimen are discussed.