The genetic structure of Staphylococcus aureus, circulating in 2008-2013 in different geographical regions of Russia and Kazakhstan by using spa-typing has been studied. Spa-types related to the clonal complex CC8 and CC239 were most predominant among MRSA strains. The need for improve an epidemiological surveillance for epidemic clones of staphylococci, including the creation of a network of reference laboratories, has been discussed.