Проведен статистический и корреляционный анализ стандартных показателей периферической крови и биохимических исследований группы пациентов с железодефицитной анемией с гастроэнтерологической патологией в анамнезе (36 человек) в сравнении с группой пациентов с хроническими кровопотерями (40 человек) до и после лечения. Полученные различные корреляционные зависимости в группах отражают многофакторность патогенетических механизмов развития железодефицитных анемий с различной этиологией. Высокая дифференциально-диагностическая достоверность статистических оценок исследованных факторов имеет существенное практическое значение. Проведено статистичний і кореляційний аналіз стандартних показників периферичної крові і біохімічних досліджень групи пацієнтів із залізодефіцитною анемією з гастроентерологічної патологією в анамнезі (36 осіб) в порівнянні з групою пацієнтів з хронічними крововтратами (40 осіб) до і після лікування. Отримані різні кореляційні залежності в групах відображають багатофакторність патогенетичних механізмів розвитку залізодефіцитних анемій з різною етіологією. Висока диференційно-діагностична достовірність статистичних оцінок досліджених чинників має істотне практичне значення. We have performed statistical and correlation analysis of standard laboratory blood indicators for patients with iron deficiency anaemia and past history of gastroenterological pathologies, as well as patients with chronic blood loss. The results suggest the role of multiple factors involved in pathogenetic mechanisms of development of iron deficiency anaemias with different aetiology, and these are supported by the associated correlations between blood indicators and the data from biochemical analyses. High level of differential diagnosis reliability of statistical estimates for the factors investigated in the context of pathogenesis of iron deficiency anaemia has substantial practical significance.
В статті представлені результати кірліанографічних досліджень на рентгенівській плівці мазків периферичної крові практично здорових осіб і пацієнтів на залізодефіцитну анемію. Встановлено розбіжності в малюнках зображень кірліанівського світіння крові в залежності від етіологічних і патогенетичних чинників анемії, що може мати прогностичне значення для перебігу анемії. Наведена комп'ютерна обробка кірліанівських зображень з будуванням їх гістограми яскравості пікселів, профілю яскравості та спектру потужності високочастотної складової зображення. Результати, що отримані, потребують подальших досліджень для використання в практичній охороні здоров'я. В статье представлены результаты кирлианографических исследований, с использованием рентгеновской пленки, мазков периферической крови практически здоровых лиц и больных железодефицитной анемией. Выявлены различия в рисунке изображений кирлиановского свечения крови в зависимости от этиологических и патогенетических факторов анемии, что может иметь прогностическое значение для течения анемии. Проведена компьютерная обработка кирлиановских изображений с построением гистограммы яркости пикселей, профиля яркости и спектр мощности высокочастотной составляющей изображения. Полученные результаты требуют дальнейших исследований для применения в практической медицине. The paper discusses the results of Kirlian analysis of X-ray images and smears of periphery blood of almost healthy people and patients with iron-deficiency anemia. Differences in the patterns of Kirlian luminescence of blood depending on ethiological and pathogenic factors have been identified, and this has the potential of being used for predicting the development of anemia. Computer analysis of Kirlian images has been performed using histograms of pixel brightness, brightness profile and the power spectrum of the high-frequency component of images. The obtained results require further studies for applications in practical medicine.
The article describes the case of the primary plasmacellular leukemia as a rare case of multiple myeloma. Attention was given to an aggressive fast progressing disease course with a lethal outcome. The features of a bone marrow blood formation was a plasmablastic infiltration with a blood formation failure. A posthumous research showed a significant diffuse focal infiltration of liver, kidney and other organs with plasmablasts. The development of an acute kidney failure was caused by the kidney leukemic infiltration with primitive plasma cells. There was the hemorrhagic pneumonia typical for acute leukemia. Diversified lytic bone lesions combined with the absence of hyperproteinemia and paraproteins peculiar for chronic forms of multiple myeloma. В статье приведено описание случая первичной плазмоклеточной лейкемии как редкой формы множественной миеломы. Обращено внимание на агрессивное, быстро прогрессирующее течение заболевания с летальным исходом. Особенностью костномозгового кроветворения являлась плазмобластная инфильтрация с депрессией кроветворения. Посмертное исследование выявило выраженную диффузно-очаговую инфильтрацию печени, почек и других органов плазмобластами. Развитие острой почечной недостаточности было обусловлено лейкемической инфильтрацией почек незрелыми плазматическими клетками. Выявлена геморрагическая пневмония, характерная для острых лейкемий. Множественные литические поражения костей сочетались с отсутствием гиперпротеинемии и парапротеина, характерных для хронических форм множественной миеломы.
The data given below show the efficiency of the therapy of the patients suffering from iron-deficiency anemia with gastroenterological pathology and helicobacter infection. The indicators of red blood of the patients from the group where they had been treated with medicine containing iron and antihelicobacterial therapy had a tendency to be higher with a prolonged compensation of anemia in comparison with the group of the patients who had not had antibacterial therapy. Finger kirliandiagnostics was offered as an express-method to identify a possible infection. The feature of a high probability of infection is intoxication in gastroduodenal zone, abdomen area and a colon.
118 adult patients with respiratory, cardiovascular, digestive, urino-genital or endocrinological diseases have been observed. Kirlian diagnostics on palm finger radiation has been used along with common clinico-laboratory methods. Data comparison of these methods showed that Kirlian diagnostics can be used in clinical differential diagnostics as an supplementary method to determine the severity of the pathological process, its pathogenesis, functional state of compensatory reactions. It helps to determine preclinical and residual signs of a disease.
As many as 48 apparently healthy subjects were examined who ranged between 20 to 24 years old. Assessment of the state of the energosystem was done by measuring energopotentials in biologically active points (BAP) as recommended by Nakatani and Makatsa. Indices for energopotentials in BAP have been found out to be dependent on the emotional-sensual, mental, i.e. psychological, state of a man, which fact is to be taken account of in interpretation thereof in the diagnostic practice. High moral-and-ethic thoughts and feelings positively influence the state of the bioenergetic balance of the system while egoistic and negative emotions have a negative effect, which fact can become one of etiological factors in the premorbid state.
Identified in patients with anemia (irrespective of its severity) were significant deviations from the norm in energopotentials on biologically active points of meridians of the lungs and pancreas--the spleen. There has been ascertained a direct relation between the degree of anemia and lowering of indices of energopotentials on biologically active points of meridians of the lungs, three heaters, liver, kidneys, urinary bladder, which fact can be taken account of in assessment of degree of the pathological process, prognostication of its course. It will be noted that indices of meridian energopotentials are affected by the psychological state of the patients. Among patients with mild anemia vs those with moderately severe anemia personal conflict can come to be a more frequently encountered etiological factor. This warrants psychotherapeutic and energy-oriented correction to be embarked on.
A total of 182 patients with acute myeloblastic leukemia and 118 patients with acute lymphoblastic leukemia. The control group was 48 essentially healthy persons. A comparative analysis was done of clinical data, means for biochemical and immunological parameters, correlations between these and characteristics of hemopoiesis. Mathematical processing was performed with the aid of the informative-and-investigative expert system HEMA. In both variants of leukemia there have been established statistically significant alterations in correlations between the studied parameters compared with healthy subject, that were more manifest in patients with acute myeloblastic leukemia.
Clinical findings were analyzed as were parameters of the peripheral blood and bone marrow in 102 patients presenting with hematodysplasias with regard to a form of the disorder and in comparison with healthy subjects. Used for the analysis was the computer system "GEMA" (Saint-Petersburg). Correlations were analyzed between the studied parameters. Differential-diagnostic differences were revealed between refractory anemia, blast surplus refractory anemia, and refractory anemia with blast surplus in the phase of transformation into acute leukosis. The results obtained can be used for their differential diagnosis, prediction of the disease course, choice of therapeutic alternatives.
A total of 464 case records of those patients with acute leukosis 15 to 80 years old have been analysed. Age was found to have unfavourable potential for achieving complete remission as well as length of life of the patients. Other parameters of prognostic significance for the course of acute leukosis (cellularity of bone marrow, enlargement of peripheral lymph nodes, percentage of blast cells in haemogramme and myelogramme, thrombocytopenia) were not recognized to be directly age-associated. Age appeared to correlate significantly with infectious complications, pneumonia, as an immediate cause of death of the patients.