Peculiarities of the course of vaginal candidiasis have been evaluated in the study. The Method for assessment of efficiency rate of immunologic reactivity of the organism, developed by authors, has been applied.

The fate of interfollicular epidermis keratinocytes which filled the hair follicles bursas of collagen dermis framework was investigated in the autotransplantation experiment. Collagen dermis framework was prepared from the skin flap. Interfollicular epidermis was detached with the help of suction method and transferred to the collagen dermis framework surface which was placed previously on the full thickness skin defect surface. It was established that in this environment keratinocytes not only developed, but some of them migrated into the hair follicle bursas cavities. It resulted in the follicular-like structures formation, cell elements of which differentiated in the manner characteristic of interfollicular epidermis. However, in spite of the fact that the epidermal cells partially retained their proliferating ability, ingrowing would completely disappear by the 15th to 20th day after the transplantation.

Under study were changes to the structure of the rat epidermis detached with the help of incomplete vacuum after its autotransplantation onto the surface of the subcutaneous fat. The epidermis was transferred from the donor area onto the receptive bed protected by a preserving chamber with the help of the glue partly soluble backing. The transplanted epidermis, despite certain traumatization during the detachment, preserves its vital capacity and is actively developing under new conditions during the whole period of the investigation (28 days). Necrotic areas are eliminated within 3 days. As long as up to the 10th day the transplanted epidermis becomes considerably thicker due to the increased amount of layers of nucleus-containing cells. On the 5-14th days there occur single ingrowths of the epidermis into the thickness of the formed granulation tissue. During the following weeks stabilization of the transplant structures takes place. However, even on the 28th day the transplanted epidermis has no morphological distinctions from the intact epidermis.