目的:观察八正散加减治疗儿童白天尿频综合征的临床疗效.方法:60例随机分成观察组30例和对照组30例.观察组用八正散加减,对照组用三金片治疗.结果:观察组总有效率高于对照组(P＜0.05).结论:八正散治疗儿童白天尿频综合征湿热证疗效较好.

Background:IgA vasculitis Nephritis (IgAVN) is a kidney-damaging disease that occurs during the course of IgA vasculitis (IgAV) and is the most serious complication of IgAV. However, there is a lack of reports of bibliometric analysis of IgAVN in children. The purpose of this study is to conduct a bibliometric analysis of IgAVN in children from 2000 to 2022, to explore the current status and cutting-edge trends in the field of IgAVN in children, and to establish new directions for subsequent research.Methods:Screening the literature in the field of IgAVN in children in the Web of Science Core Collection (WoSCC) from 2000 to 2022. Visual analysis of their annual publications, countries, institutions, authors, journals, keywords, and references were using CiteSpace5.8.R3 and VOSviewer1.6.18.Results:A total of 623 publications were included in the study, since the beginning of 2014, there has been an overall increasing trend in the number of articles issued. The most prolific country and institution were China and Zhejiang University. The most frequently cited author was Coppo R, with 331 citations, who has made great contributions to IgAVN. Mao Jianhua, Lee JS and Wyatt Robert J were the most prolific authors, all with 9 articles. Pediatric Nephrology was the most published and cited journal. The highest burst strength keyword is IgA vasculitis, and the highest burst strength reference is Davin JC, 2014.Conclusion:The research hotspots and trends predicted by the analysis of this study provide a reference for in-depth research in this field with a view to promoting the development of IgAVN research in children.

目的:观察阿奇霉素序贯治疗联合麻杏石甘汤加味对痰热闭肺型肺炎支原体肺炎(MPP)患儿辅助性T细胞17(Th17)/调节性T细胞(Treg)细胞因子和NOD样受体蛋白3(NLRP3)炎症小体通路的影响.方法:选择山东省中医院2019年4月～2021年5月期间收治的痰热闭肺型MPP患儿106例,根据随机数字表法分为对照组和研究组,各为53例,对照组患儿接受阿奇霉素序贯治疗,研究组患儿接受阿奇霉素序贯治疗联合麻杏石甘汤加味治疗,对比两组疗效、中医证候积分、Th17/Treg细胞因子和NLRP3炎症小体通路相关指标,记录两组不良反应发生情况.结果:与对照组相比,研究组的临床总有效率明显更高(P＜0.05).两组治疗后次证积分、主证积分、总积分均较治疗前下降,且研究组低于对照组(P＜0.05).两组治疗后白介素-17A(IL-17A)、白介素-25(IL-25)水平均较治疗前下降,白介素-10(IL-10)、白介素-35(IL-35)水平均较治疗前升高,且研究组的变化程度大于对照组(P＜0.05).两组治疗后NLRP3 mRNA、接头蛋白凋亡相关斑点样蛋白(ASC)mRNA、半胱天冬酶1(caspase-1)mRNA均较治疗前下降,且研究组的下降程度大于对照组(P＜0.05).两组在治疗期间均未曾出现明显不良反应.结论:阿奇霉素序贯治疗联合麻杏石甘汤加味治疗痰热闭肺型MPP患儿疗效显著,可促进症状改善,作用机制可能与调节Th17/Treg细胞因子和NLRP3炎症小体通路有关.