BACKGROUND:Post-COVID-19, macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) has surpassed 90% prevalence in East Asia. Modified Ganlu Xiaodu Decoction (MGLXDD), derived from the classic Chinese herbal medicine for against plague Ganlu Xiaodu Decoction, demonstrates beneficial effects in treating MPP, though its therapeutic mechanism remains unclear. PURPOSE:To explore the potential mechanism of MGLXDD on MPP. METHODS:MPP mouse model, macrophage (THP-1) and airway barrier cell (A549 and BEAS-2B) co-culture system were established. The effects of MGLXDD on inflammation and airway barrier injury were evaluated using histopathological and immunohistochemical techniques. Transcriptomics and proteomics were performed to screen key targets and pathways of MGLXDD in treating MPP. Bioactive compounds of MGLXDD were identified by mass spectrometry. Molecular docking and surface plasmon resonance (SPR) were employed to evaluate the binding affinity of bioactive compounds to ZBP1, the main sensor of PANoptosis. Using siRNA knockdown, immunofluorescence, electron microscopy, and flow cytometry, the central role of ZBP1-mediated PANoptosis in MPP-related cytokine storm and epithelial barrier injury, and the therapeutic effects of MGLXDD on this process, were verified. RESULTS:MGLXDD effectively alleviated the severe inflammatory response and airway barrier injury caused by mycoplasma pneumoniae (MP) both in vivo and in vitro. The multi-omics showed that the ZBP1-mediated PANoptosis played a key role in the pathogenesis of MPP, and MGLXDD significantly inhibited this pathway. Mechanistic research verified that MP infection specifically activated ZBP1 in macrophages, triggering a PANoptosis cascade. By reducing ZBP1 expression, activation of key PANoptosis-related molecules, including caspase-1, MLKL, and caspase-3, was effectively inhibited, significantly alleviating inflammation and barrier injury. SPR analysis and both in vitro and in vivo experiments demonstrated that the bioactive components of MGLXDD can directly bind to the ZBP1 protein, suppress PANoptosis by modulating ZBP1 expression, and thereby exert therapeutic effects. CONCLUSION:ZBP1-mediated PANoptosis is the core pathological mechanism underlying airway barrier injury in MPP. MGLXDD achieves dual anti-inflammatory and airway protective effects by specifically targeting the ZBP1 and inhibiting its mediated PANoptosis, offering a potential therapeutic strategy for drug-resistant MPP.

BackgroundIn recent years, the incidence of Crohn's disease has risen significantly in the pediatric population, and its prolongation has had a major impact on children's physical and mental health as well as on the quality of life of their families, and has therefore received extensive attention from scholars around the world. A large number of articles have been published on Crohn's disease in children; however, there is still a lack of studies that use visualization methods for bibliometric analysis of relevant literature. The purpose of this paper is to statistically analyze the published literature in the field of Crohn's disease in children in order to help in the future diagnosis and treatment of Crohn's disease in children.MethodsLiterature meeting the inclusion criteria was screened from the Web of Science Core Collection database. Literature was visualized and analyzed by author, country, institution, journal, reference, and keyword using Citespace (6.2.R4) and VOSviewer (1.6.18).ResultsA total of 3,177 eligible publications were included. There is an overall increasing trend in the number of annual publications.Turner, Dan published the most number of articles with 78 and has a high impact in the field of CD. The most cited author was Levine, A. Among countries and institutions, the United States and Tel Aviv University had the highest number of publications. The journal with the most publications is Journal Of Pediatric Gastroenterology And Nutrition. The most co-cited journal was Inflammatory Bowel Diseases. The most cited document was ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents, and the most cited document with the highest outbreak intensity was The Medical Management of Paediatric Crohn's Disease: an ECCO-ESPGHAN Guideline Update.The most frequent keyword was “inflammatory bowel disease”.ConclusionThis study provides a visual summary of information for the field of pediatric Crohn's disease and contributes to international collaboration to promote research in the field of pediatric Crohn's disease.

The incidence of infectious mononucleosis (IM) has increased in recent years, particularly in the pediatric population, and there are currently no specific drugs available, posing a threat to the lives and health of children worldwide. Although some results have been published, there is a lack of systematic review and summarization of current research. Based on screening criteria, literature on IM in children from 2000 to 2023 was retrieved from the Web of Science Core Collection. The included literature’s indicators (country, institution, journal, author, keywords, and references) were analyzed and visualized using Citespace, VOSviewer software, and the Bibliometrix program package. A total of 538 eligible publications were included in this study. The number of publications has been on an upward trend during this century, with great potential for future growth. The countries with the most publications are the USA and China, and Capital Medical University is the most contributing institution. Hjalgrim, Henrik and Cohen, Jeffrey, I are among the field’s most influential authors and co-cited authors. Among the major journals, the JOURNAL OF MEDICAL VIROLOGY had the highest output and the JOURNAL OF INFECTIOUS DISEASES was the most frequently cited. The reference with the highest outbreak intensity was Ramagopalan, SV, LANCET NEUROLOGY, 2010. Through in-depth analysis of the keywords, we conclude that the characteristics of diagnosis and assessment of IM, the association of IM with other diseases, and interventions for IM are the current hot topics of research in the field and that the pathogenesis of IM due to EBV is a cutting-edge topic in the field. This study also analyzes the reasons for geographical research differences and proposes a new “increasing quantity-improving quality-integrating” cooperation model. This study’s hotspots and frontiers reflect the current status and trends in pediatric IM, and these findings provide important insights to guide future research and optimize therapeutic strategies. In the future, there is a need to strengthen international collaboration and cooperation, conduct RCTs with large sample sizes, and promote the development of new drugs in mechanism research.

Polycythemia vera (PV) is a myeloproliferative tumor with low incidence and complex symptoms, affecting patients' quality of life and shortening their life span. Since the beginning of the 21st century, there has been an update but a need for uniform consensus regarding diagnosing and treating PV. With the continued interest of researchers in this field, a bibliometric study of PV is necessary. This paper aims to analyze articles on PV through bibliometric software to provide collaborative information and new ideas for researchers in this field. We collected PV-related publications in the Web of Science Core Collection database from 2000 to 2023. The included literature was analyzed using Citespace (6.2.R2), VOSviewer (1.6.19), and Bibliometrix. The study included country/region, institution, authors, journals, keywords, and references, and a visual knowledge network diagram was constructed. Microsoft Excel 2013 was also used for statistical analysis. A total of 1,093 articles were eventually included. The number of PV-related publications has steadily increased from 2000 to the present, with great potential for future growth. The US and US institutions have contributed more to this field, with the US ranking first in the number of publications, total citations, and centrality. Alessandro M. Vannucchi is the most published author. Tefferi, Ayalew is the most cited author. And BLOOD has the most publications, topping the list of the eleven high-productivity core source journals. The most cited article was "Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders" (Baxter, EJ, 2005). By examining the keywords, we found that the diagnosis and typing of true erythrocytosis, the use of ruxolitinib, and the tyrosine kinase JAK2 are the research hotspots in the field; genetic and molecular research in the field of true erythrocytosis is a cutting-edge topic in the field; and risk factors for true erythrocytosis is a cutting-edge hotspot issue in the field. The fruitful research in this century has laid the foundation for developing the field of PV. The information in this article will provide researchers with current hotspots and future potential in the discipline, helping the field achieve more extraordinary breakthroughs. Currently, research should focus on increasing global multicenter collaborative research in diagnosis and treatment to develop scientifically recognized diagnostic and treatment protocols and new clinical drug research. Our proposed model of global innovation collaboration will provide strong support for future research.

BackgroundCerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease associated with lipid metabolic disorders. Because of its clinical diversity and rarity, the diagnosis is often unclear. However, there is still a lack of reports on bibliometric analysis of CTX. The aim of this study was to assess the progress and research developments of CTX over the past three decades, identify emerging trends, and establish novel directions for future research.MethodsThe eligible literature were screened from the Web of Science Core Collection (WoSCC) database. The annual publication, countries, institutions, authors, journals, keywords and references were visually analyzed by Microsoft Excel 2019, CiteSpace 6.2.R4, VOSviewer 1.6.18 and online bibliometrics website (https://bibliometric.com/).ResultsA total of 561 publications from WoSCC were included in this study. The United States is the country with the largest number of publications, and Karolinska Institutet is the institution with the largest number of publications. Björkhem I. ranks as the most published and cited author in the last three decades. Journal of Lipid Research is the most widely published and cited journal. The strongest burst of keywords is “diagnosis.”ConclusionUnraveling the pathogenesis of CTX and improving its diagnosis and treatment continue to be critical challenges that require urgent attention. Future research endeavors will be centered on enhancing the efficiency and accuracy of early diagnosis and intervention.

BackgroundNoonan syndrome (NS) is a rare group of autosomal genetic disorders. In recent years, with the exploration and development of molecular diagnostic techniques, more and more researchers have begun to pay attention to NS. However, there is still a lack of reports on the bibliometric analysis of NS worldwide. This study aims to assess the current research status and development trend of NS, to explore the research hotspots and emerging topics, and to point out the direction for future scientific research.MethodsWeb of Science Core Collection was selected as the search database for bibliometric analysis of NS-related publications from 1998 to 2023. Statistical and visual analysis of the number of publications, countries, institutions, authors, journals, keywords, and references were analyzed using Citespace, VOSviewer, Scimago Graphica, and BibliometrixR.ResultsA total of 2041 articles were included in this study. The United States had the highest number of publications, and Istituto Superiore di Sanità, Italy, was the institution with the highest number of publications. TARTAGLIA M was the scientist with the highest number of publications and citations. Among the journals, AMERICAN JOURNAL OF MEDICAL GENETICS PART A has the highest output, and Nature Genetics is the most frequently cited. The reference with the highest outburst intensity is Roberts AE, LANCET, 2013. the cluster diagram divides all the keywords into seven categories, with the most vigorous outburst being “of function mutations.”ConclusionResearch hotspots in the field of NS focus on the correspondence between NS genotype and phenotype and the precise diagnosis of NS. Future research efforts will explore more deeply from the perspective of long-term intervention strategies for NS. There is an urgent need to rely on significant research countries, institutions, journals, and authors to lead the construction of a more robust global collaborative network that will enhance research efficacy.

Lupus nephritis (LN) is a complication of systemic lupus erythematosus and a damaging disease of the kidney. The injury of LN in children is more serious than that in adults. However, the literature in this field is numerous and complex, which brings great challenges for researchers to extract information. The purpose of this study is to carry out bibliometric analysis and visualization of published literatures, and identify current research hotspots and future research trends in this field. Literature was retrieved from the Web Of Science database from 1999 to 2022. The literature was analyzed and visualized using Citespace 6.1.R6, VOSviewer 1.6.18, and Microsoft Excel 2019. A total of 1059 articles were included in this study. In the past 13 years, an increase in the number of publications every year. Brunner HI is the author with the highest number of published and cited papers in this field, followed by Wenderfer SE. The United States and China are the countries with the highest number of published papers. University Toronto is the most productive institution, followed by University Cincinnati. The most prolific journal was Pediatric nephrology (IF 2.67), followed by lupus (IF 2.21). Lupus was cited the most, followed by Pediatric nephrology. The keyword burst showed the earliest and longest burst was antiphospholipid antibody, validation/risk/rituximab/safety is the current research hotspot. The article with the highest number of citations was Hochberg MC 1997 published in Arthritis Rheum. This study provides valuable information summary for the field of LN in children, which is helpful to strengthen the cooperation among countries, institutions and authors, and promote the research in the field of LN in children.

Bronchiolitis obliterans (BO) is a rare and irreversible chronic respiratory disease. The diagnosis of BO is challenging, and there still needs to be specific therapies and uniform treatment guidelines available. Research on BO has grown steadily over the past 20 years, and with the continued interest of researchers in this area, a bibliometric study of BO becomes necessary. This topic aims to assess the current state of research in BO over the last 2 decades and to identify research hotspots and emerging directions. Information on BO-related articles were obtained from the Science Citation Index Expand of the Web of Science Core Collection (WOSCC [SCI-E]) database. Citespace (6.1.R6), VOSviewer (1.6.18), and the online bibliometrics website (https://bibliometric.com/) were used for bibliometric analysis mainly to include country/region, institution, author, journal, keywords, and references and to construct visual knowledge network diagrams. A total of 4153 publications from the WOSCC [SCI-E] database were included in this study. Most publications come from the United States, Japan, and Germany, which collaborate relatively more frequently. Research institutions in the United States, especially the University of Washington, published the largest number of BO-related articles. Regarding authors, Vos, R is the most productive author, while Verleden, GM is the most influential in BO. In addition, JOURNAL OF HEART AND LUNG TRANSPLANTATION is the journal with the most published articles. The most cited article is Estenne M, 2002. Based on the clustering analysis of keywords and references, the diagnosis of bronchiolitis obliterans syndrome (BOS), treatment of BOS, and risk factors of BO are the current research hotspots and future research trends. We analyzed the publication trends in BO by bibliometrics and mapped the knowledge network of major contributing countries/regions, institutions, authors, and journals. Current research hotspots were found based on the main keywords and references. The outcome may help researchers identify potential collaborators, collaborating institutions, and hot fronts in BO to enhance collaboration on critical issues and improve the diagnosis and treatment of BO.

目的:本研究基于"真实世界"数据和生物信息学技术并依据HIS系统对PNS住院患儿中药处方资料进行统计分析用药规律,探讨原发性肾病综合征(PNS)的发病机制及用药特点.方法:从NCBI、OMIM、Disgenet数据库中获取PNS相关靶点,通过DAVID、STRING数据库获得KEGG通路与蛋白互作网络筛选关键基因,通过Symmap数据库与山东省中医院HIS系统,寻找治疗PNS的核心中药.结果:筛选得到13个PNS核心靶点,如TNF、EGFR、VEGFA等;18味核心中药,如桂枝、黄芪、茯苓等利水渗湿、温阳益气类药物.结论:本研究初步探索了PNS的发病机制,探寻中医药治疗PNS的用药特点及规律,为PNS的精准治疗提供了理论依据.

Refractory nephrotic syndrome in children is a relatively difficult kidney disease in pediatrics,of which the course of disease is prolonged,the symptoms are stubborn and it is easy to repeat. Based on the theory of the liver is “yin in property and yang in function”,and combined with the physiological and pathological characteristics of children,Professor PAN Yueli proposed that the abnormal function of the liver is closely related to refractory nephrotic syndrome in children and emphasized the role of liver in the occurrence and development of refractory nephrotic syndrome in children. It is proposed to treat the disease from the liver differentiation,pay attention to nourishing the liver,regulating the function of the liver,and make good use of wind medicine,taking the above as the pivot,regulating the circulation of qi,blood and body fluid and improving the function of the viscera can achieve the goal of treating the disease. One successful case is attached.

目的:观察八正散加减治疗儿童白天尿频综合征的临床疗效.方法:60例随机分成观察组30例和对照组30例.观察组用八正散加减,对照组用三金片治疗.结果:观察组总有效率高于对照组(P＜0.05).结论:八正散治疗儿童白天尿频综合征湿热证疗效较好.

Adrenal neuroblastoma is a malignant tumor with high incidence in children, and because of its insidious onset and diverse and non-specific clinical symptoms, it is mostly stage four when identified. Early clinical detection is difficult and diagnosis is often delayed. Through the analysis and summary of two cases of adrenal neuroblastoma misdiagnosed recently in Shandong Provincial Hospital of Traditional Chinese Medicine, the reasons for the misdiagnosis of this disease were systematically reviewed from the grassroots level and disease characteristics, which will provide a reference for pediatricians to clinically diagnose and identify adrenal neuroblastoma in order to reduce misdiagnosis and mistreatment.

真性红细胞增多症发病率低、症状复杂,在诊治时常遇到"无法可循"的困境,本文以"选取主症,视症为病,探求病因,辨证选方"为思路,选取犀角地黄汤加减治疗,效果显著,印证了中医辨证论治的有效性,也为罕见病、疑难病的中医治疗拓宽了思路和方法.

PAN Yueli believed that the pathogenesis of gan Qi type malnutrition was due to the failure of spleen-Yang to rise,obstruction of stomach-collaterals,and liver-Qi deficiency leading to the disappearance of fluids and stagnation of Qi and blood.The treatment focused on the flexible use of promoting Yang Qi,clearing up the collaterals Qi,and activating stagnation Qi to regulate the spleen,stomach,and liver.It advocated identifying the urgency of the disease,treating both the symptoms and the root cause,and adding and subtracting medicine according to the symptoms.Clinical prescriptions should be in accordance with the principles of promoting spleen-Yang and not over-supplementing,promoting stomach-collaterals and not over-stasis,and de-stagnating liver-Qi according to the changes of the disease,it achieved significant treatment results.A test case was attached to support this.

张介宾在《景岳全书》中倡言"阳非有余,阴常不足",强调并阐述了命门水火和阴阳互根理论,纠正寒凉时弊.其中《小儿则》部分以温补理论为基础对张介宾诊治儿科疾病的治则治法和用药特点进行了论述.文中结合张介宾对小儿生理病理特点的认识,从谨慎用药、酌用苦寒、善用温补、巧施清凉、重视气血、顾护脾肾、剂型多样七个方面深入探讨张介宾在儿科方面的用药特色,以期为今世儿科临床用药提供参考和指导.

Background:In recent years, the incidence of Kawasaki disease among the pediatric population has experienced a significant increase. With complications mainly affecting the cardiovascular system, Kawasaki disease has received widespread attention from scholars worldwide. Numerous articles on Kawasaki disease in children have been published far. However, there is a lack of studies that use visualization methods to perform a bibliometric analysis of the relevant literature. This study aims to obtain overall information on the output characteristics of publications on childhood Kawasaki disease between 2012 and 2022 through bibliometric analysis, identify research hotspots and frontiers, and provide new ideas and references for future clinical and scientific research.Methods:Literature meeting the inclusion criteria was screened from the Web of Science Core Collection, PubMed, and Scopus databases. Visual analysis of the literature by country, institution, journal, author, keywords, and references was performed using Citespace (6.1.R6), VOSviewer (1.6.18), and the online bibliometric website (https://bibliometric.com/).Results:A total of 4,867 eligible publications were included. The number of annual publications is generally rising, rapidly increasing since 2019. Among countries and institutions, China and KAOHSIUNG CHANG GUNG MEMORIAL HOSPITAL have the highest output of articles. With 104 publications, Ho-Chang Kuo has a high impact in the field of KD. The most cited author is Jane W. Newburger. The most prolific journal is FRONTIERS IN PEDIATRICS. CIRCULATION is the most frequently co-cited journal. The most popular keyword in frequency and centrality is "immunoglobulin". The reference with the highest burst intensity was Verdoni L, LANCET, 2020.Conclusion:Kawasaki disease in children remains a hot topic among pediatricians worldwide and is receiving increasing attention. We innovated the "national-institutional-journal" model, which promotes further international cooperation in this field. The hot topics in the field of pediatric KD are "KD pathogenesis", "immunoglobulin resistance and complementary therapy", and "cardiovascular complications". Frontiers include disease-related ("multisystem inflammatory syndrome", "coronavirus disease 2019", "hypotension"), treatment-related ("procalcitonin", " anakinra"), and pathogenesis ("polymerase chain reaction").

BACKGROUND:Polygoni Cuspidati Rhizoma et Radix (PCRR), a well-known traditional Chinese medicine (TCM), inhibits inflammation associated with various human diseases. However, the anti-inflammatory effects of PCRR in acute lung injury (ALI) and the underlying mechanisms of action remain unclear.AIM:To determine the ingredients related to PCRR for treatment of ALI using multiple databases to obtain potential targets for fishing.METHODS:Recognized and candidate active compounds for PCRR were obtained from Traditional Chinese Medicine Systems Pharmacology, STITCH, and PubMed databases. Target ALI databases were built using the Therapeutic Target, DrugBank, DisGeNET, Online Mendelian Inheritance in Man, and Genetic Association databases. Network pharmacology includes network construction, target prediction, topological feature analysis, and enrichment analysis. Bioinformatics resources from the Database for Annotation, Visualization and Integrated Discovery were utilized for gene ontology biological process and Kyoto Encyclopedia of Genes and Genomes network pathway enrichment analysis, and molecular docking techniques were adopted to verify the combination of major active ingredients and core targets.RESULTS:Thirteen bioactive compounds corresponding to the 433 PCRR targets were identified. In addition, 128 genes were closely associated with ALI, 60 of which overlapped with PCRR targets and were considered therapeutically relevant. Functional enrichment analysis suggested that PCRR exerted its pharmacological effects in ALI by modulating multiple pathways, including the cell cycle, cell apoptosis, drug metabolism, inflammation, and immune modulation. Molecular docking results revealed a strong associative relationship between the active ingredient and core target.CONCLUSION:PCRR alleviates ALI symptoms via molecular mechanisms predicted by network pharmacology. This study proposes a strategy to elucidate the mechanisms of TCM at the network pharmacology level.

BackgroundRarity limits the breadth of study on clear cell sarcoma of the kidney (CCSK). There is currently no predictive model that quantifies the overall survival (OS) of CCSK and a few large sample-based analysis of relapse-related factors.MethodsPatients were collected both from the Surveillance, Epidemiology, and End Results (SEER) database and case report articles extracted from the global online document database to form 2 groups. The first was the OS group, which was used to build and verify the nomogram for predicting the OS of CCSK. Independent predictors of OS were screened by Cox regression analysis to develop the nomogram. Nomogram accuracy was assessed by C-index, receiver operating characteristic (ROC), calibration, and decision curve analysis (DCA) curves. In addition, the difference in OS between receiving radiotherapy or not in stage I patients was analyzed by the Chi-square test. The second was the relapse group, which was used to analyze the relapse-related factors by Cox regression analysis and the Kaplan–Meier method with the log-rank test.Result256 patients were included in the OS group. The stage, chemotherapy, and radiotherapy were independent OS-related factors of CCSK, and the nomogram for predicting the OS of CCSK was established based on them. The results of the C-index, ROC, calibration, and DCA curves showed that the nomogram has good discrimination, accuracy, and clinical profitability. The Chi-squared test showed no significant difference in OS with receiving radiotherapy or not in stage I patients. The relapse group included 153 patients, of which 60 relapsed. The univariate Cox regression analysis showed no correlation between radiotherapy and relapse. The multivariate Cox regression analysis showed that stage and surgery/chemotherapy sequence were the independent factors for relapse. The log-rank test of seven chemotherapeutic drugs showed that etoposide (E), cyclophosphamide (C), vincristine (V), and doxorubicin (D) (all P < 0.05) had significant differences in preventing relapse, and then drew the relapse-free survival curves of these four drugs.ConclusionOur nomogram accurately quantified the OS of CCSK. There was no significant difference in OS between receiving radiotherapy or not in stage I patients. Stage, surgery/chemotherapy sequence, and the use of ECVD were relapse-related factors. Radiotherapy had no significant contribution to preventing relapse.

Background:IgA vasculitis Nephritis (IgAVN) is a kidney-damaging disease that occurs during the course of IgA vasculitis (IgAV) and is the most serious complication of IgAV. However, there is a lack of reports of bibliometric analysis of IgAVN in children. The purpose of this study is to conduct a bibliometric analysis of IgAVN in children from 2000 to 2022, to explore the current status and cutting-edge trends in the field of IgAVN in children, and to establish new directions for subsequent research.Methods:Screening the literature in the field of IgAVN in children in the Web of Science Core Collection (WoSCC) from 2000 to 2022. Visual analysis of their annual publications, countries, institutions, authors, journals, keywords, and references were using CiteSpace5.8.R3 and VOSviewer1.6.18.Results:A total of 623 publications were included in the study, since the beginning of 2014, there has been an overall increasing trend in the number of articles issued. The most prolific country and institution were China and Zhejiang University. The most frequently cited author was Coppo R, with 331 citations, who has made great contributions to IgAVN. Mao Jianhua, Lee JS and Wyatt Robert J were the most prolific authors, all with 9 articles. Pediatric Nephrology was the most published and cited journal. The highest burst strength keyword is IgA vasculitis, and the highest burst strength reference is Davin JC, 2014.Conclusion:The research hotspots and trends predicted by the analysis of this study provide a reference for in-depth research in this field with a view to promoting the development of IgAVN research in children.

目的 利用Citespace分析近10年中医药治疗肾病综合征(Nephrotic syndrome,NS)的文献研究状况,探讨此领域的研究热点和研究趋势.方法 检索中国知网数据库关于中医药治疗NS的相关文献,将其导入Citespace知识图谱,对作者、机构、关键词进行可视化分析.结果 共纳入1332篇相关文献.发文量基本稳定,总体呈下降趋势.作者合作图谱共有413位作者纳入,其中核心作者有55位,6个合作团队内部初成规模.机构合作图谱共有320个机构被纳入,形成2个跨区域合作团队.关键词图谱共有479个关键词被纳入,其中高中心性(>0.1)关键词有36个,近3年突现的关键词为加味防己黄芪汤、脾肾阳虚证.结论 中医药治疗NS研究热点主要为难治性NS和儿童NS的中西医结合治疗,研究趋势可能为深入研究经方的治疗机制、筛选脾肾阳虚型NS的核心靶点并进行早期干预.