目的 探讨硬性耳内镜下鼓室置管术、鼓膜切开术及穿刺术治疗分泌性中耳炎的临床疗效及安全性.方法 90例保守治疗无效的分泌性中耳炎患者随机分3组,置管组采用耳内镜下鼓室置管术,切开组采用鼓膜切开术,穿刺组采用鼓膜穿刺术治疗,观察对比三种治疗方法的治疗效果、并发症及复发情况.结果 三组患者的临床总有效率及并发症情况均有统计学意义,置管组的临床有效率明显高于后两组,并发症发生率明显低于后两组.结论 硬性耳内镜下鼓室置管手术,视野宽、清晰,立体感强,手术操作精细、创伤小,疗效可靠,并发症及复发率低,可同期处理腺样体疾病,值得临床推广应用.

Objective To investigate the relationship between virus load in urine and abnormal brainstem auditory evoked potential ( BAEP) in human cytomegalovirus ( CMV) infected infants .Methods 160 infants aged 10 days to 3 months diagnosed etiologically as CMV infection were included in this study .The copy number of CMV -DNA in urine ranged from 1.797 ×104/ml to 5.62 ×107/ml.The infants were divided into 4 groups according to the power and expo-nent of CMV-DNA in urine:104(n=72),105(n=40), 106(n=28), and 107(n=20).BAEP was detected for each group.Results There was a positive-relationship between the abnormal BAEP and the copy number of CMV -DNA in urine.The increased objective auditory threshold , prolonged incubation period of wave Ⅰ,Ⅲ,Ⅴand inter-phase be-tween the wave of Ⅰ-Ⅲ, Ⅲ-Ⅴ, Ⅰ-Ⅴ were correlated with increased copy number of CMV -DNA in urine in CMV infected infants (P<0.01).Conclusion In infants with CMV infection, progressive sensorineural hearing loss is associated with increased urine CMV load .