本文回顾了王伯祥教授治疗肝病尤重瘀血的学术思想和善用活血化瘀药物的临床经验,总结了该团队在"肝病血瘀证"临床和实验研究的成果,阐述了该团队在此基础上构建"毒损肝络"假说的具体内容和临床应用,提出以分期辨证取代分型辨证诊疗体系的构想.

[Objective] To observe the anti - aging effects and explore the mechanism of Qibao Meiran Pellet (QMP) and its modified prescriptions, including QMP with qi - invigorating and spleen - strengthening herbs, with kidney -nourishing herbs or with blood - activating and purgative herbs. [ Methods ] Ten - month - old model rats were established by D - galactose. Serum free radical levels and immune indexes in QMP group and various modified QMP groups were observed. [ Results ] QMP increased the activity of superoxide dismutase ( SOD). QMP combined with kidney - nourishing herbs or blood - activating and purgative herbs decreased the serum level of malondialdehyde (MDA) and increased the activities of glutathione peroxidase (GSH - Px) and SOD. Meanwhile, QMP combined with kidney -nourishing herbs increased interleukin - 2 activities. [ ConclusionJ QMP, mainly composed of herbs for nourishing liver and spleen, can delay the aging of rats, and spleen - strengthening herbs and blood - activating and purgative herbs also play an important role in the delay of aging. Furthermore, it is suggested that the anti - aging effect of herbal medicine is related to the sex.

肌萎缩侧索硬化症属中医痿证范围,为临床疑难病症.李任先教授认为本病以脾肾亏虚为本,虚风内动为标,存在血脉不畅之病理因素;临证自拟健脾补肾方,以健脾补肾、熄风止痉、活血通络为法治疗,取得满意疗效.

溃疡性结肠炎,又名非特异性溃疡性结肠炎,世界卫生组织称为特发性结肠炎,是一种以腹痛、腹泻、粘液便、血便为主要临床表现的非特异性炎症性结肠疾病.

肝病血瘀证是慢性病毒性肝炎、肝纤维化、肝硬化的常见证型,特别是在肝病的后期,可见胁部疼痛、肝脾肿大或压痛、毛细血管扩张症、腹壁静脉充血、出血、舌暗或有瘀斑、脉涩等瘀血阻滞的表现.肝病属"杂气"致病,性多湿热,湿热邪毒是其主要病因,而血瘀是其病理产物[1],本文就邪毒内侵导致肝病血瘀的机理进行初步探讨.

Objective: To make a practical animal model with liver blood stasis caused by pathogenic factor. Methods: 1-day-old Wuhan ducklings were inoculated from shin-vein with serum containing DHBV to establish liver blood stasis animal model and prevented and treated with Jiedu Ruangan Tang. Series of indexes were observed, such as microcirculation of bulbar conjunctiva, blood rheology, liver funetion, hepatic fibrosis, tissue pathology. Results: The animal models had marked microcirculation disturbence of bulbar conjunctiva and changes in blood rheology. And the albumin decreased, globulin, MDA, serum PC Ⅲ , HA, LN and liver tissue Hyp increased. There existed hepatocytes edema, fatty degeneration, leydig's cells infiltration, fiber regeneration and virus granule from optical and electro microsscopic analysis. Jiede Ruangan Tang could decrease MDA, indexes of hepatic fibrosis and blood rheology, release liver tissue pathological changes, and improve liver function, microcirculation of bulbar conjunctiva (P0. 01). There existed doses dependance. Conelusions: Pathogenic factor continously attaching duck could form duck liver blood stasis, and markedly related to the damage of lipid peroxide, the changes of blood rheology, microcirculation, disturbance, degeneration and neerosis of hepatocytes, regeneration of collagenous fibers.