This paper introduces Professor CUI Yun's clinical experience in diagnosing and treating oligoasthenospermia based on the homogeny of liver and kidney theory.Professor CUI Yun believes that the core pathogenesis of oligoasthenospermia lies in kidney deficiency and liver constraint.He proposes that liver constraint is the beginning of all diseases in men,and kidney deficiency is the root of all diseases in men.He advocates the use of the homogeny of liver and kidney theory to diagnose and treat oligoasthenospermia,and has formed the treatment characteristics of"tonifying both liver and kidney to promote the mutual transformation of essence and blood",and"soothing the liver and tonifying the kidney to promote the smooth flow of qi and blood",and"nourishing the kidney and clearing the liver to promote the harmony of wood and water".The treatment is well-equipped with theory,method,prescription,and medicine,and has significant characteristics,which often achieves good results in clinical practice.
目的:观察通窍活血汤对蛛网膜下腔出血(SAH)大鼠的神经保护作用,并探讨其作用机制.方法:将60只SD大鼠随机分为假手术组,模型组,通窍活血汤低、中、高(3、6、12g/kg)剂量组各12只.采用改良二次枕大池注血法制作SAH大鼠模型.造模成功后,通窍活血汤低、中、高剂量组大鼠分别灌胃对应剂量的通窍活血汤溶液治疗,假手术组和模型组大鼠灌胃等量的0.9％氯化钠溶液,连续灌胃7d.于治疗第1、3、5、7天评估各组大鼠Bederson神经功能评分;每组各取6只大鼠,在治疗第3、7天分批取材,采用酶联免疫吸附法检测各组大鼠海马组织肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平;免疫组织化学法测定各组大鼠醌氧化还原酶1(NQO-1)、核因子E2相关因子2(Nrf2)蛋白表达.结果:与假手术组比较,模型组大鼠在治疗第1、3、5、7天的Bederson神经功能评分均升高(P＜0.05);通窍活血汤中、高剂量组大鼠在治疗第5、7天的Bederson神经功能评分均较模型组降低(P＜0.05).与假手术组比较,模型组大鼠治疗第3、7天海马组织中TNF-α、IL-1β含量明显升高(P＜0.01),海马齿状回区NQO-1、Nrf2蛋白表达明显降低(P＜0.01);与模型组比较,通窍活血汤低、中、高剂量组大鼠治疗第3、7天海马组织中TNF-α、IL-1β含量降低(P＜0.01),通窍活血汤低、中、高剂量组大鼠海马齿状回区NQO-1、Nrf2蛋白表达升高(P＜0.05).结论:通窍活血汤可通过抗氧化应激,减轻炎性反应来改善SAH大鼠神经功能,其机制与调节Nrf2-抗氧化反应元件(Nrf2-ARE)信号通路下游NQO-1、Nrf2蛋白水平有关.
Guangdong-Hong Kong-Macao Greater Bay Area,a national development strategic area,has built an important promotion platform for the international communication of Chinese medicine with unique conditions.However,due to various factors,Chinese medicine in this region has its regional particularity of Lingnan Area,and there are also diversity and differences in the geographical,climatic and physiological conditions of people around the world.Therefore,it is necessary to rethink the difficulties and solutions that may be encountered in the international communication of Chinese medicine.By analyzing the advantages and disadvantages of international communication of Chinese medicine in Guangdong-Hong Kong-Macao Greater Bay Area,this paper proposes to promote the international communication of Chinese medicine in the Guangdong-Hong Kong-Macao Greater Bay Area from three aspects:identification of Chinese medicine status,source-based communication and modern technology.It is hoped that this will be a breakthrough to face the possible problems in the international communication of Chinese medicine in a dynamic and personalized way.
Objective:To apply the compatibility regularity of acupoints of acupuncture and moxibustion for obese polycystic ovary syndrome based on data mining.Methods:The China National Knowledge Infrastructure(CNKI)database,Wanfang Knowledge Service Platform,VIP database(VIP)and PubMed were searched for clinical research literature on the treatment of obese polycystic ovary syndrome published from the establishment of the database to September 2022.By using Microsoft Excel 2022,a database was established for standardization and to conduct descriptive analysis of the data.SPSS Modeler18.0 Apriori algorithm was used for association rule analysis and drawing of high-frequency point co-occurrence network diagram.SPSS Statistics 25.0 was used for intergroup clustering analysis and to draw ice column and tree charts.Results:A total of 67 articles were included,involving 98 acupuncture and moxibustion prescriptions,83 acupoints,and 739 times of application frequency of total acupoints.The acupoints of top four application frequency were Guanyuanpoint(RN 4),Sanyinj iaopoint(SP 6),Tianshupoint(ST 25),and Zusanlipoint(ST 36);The channels with top three frequency were the foot yangming stomach channel,ren mai,and the foot taiyang bladder channel.Applied acupoints were mostly distributed in the abdomen and lower limbs;Specific acupoints were mostly front-mu point and back-shu point.The association rule showed that the acupoint combination with the highest support is Guanyuan-Zhongj i.The top 20 high-frequency acupoints can be divided into three effective clustering groups.Conclusion:Acupuncture and moxibustion for obese polycystic ovary syndrome focuses on regulating the spleen and stomach,and also soothing the liver and tonifying the kidney.The prescription combination is mainly composed of Guanyuan point(RN 4),Tianshu point(ST 25),and Zusanli point(ST 36),and the syndrome differentiation is supplemented by acupuncture points for resolving phlegm,promoting blood circulation and nourishing blood to improve clinical effects.
Objective:To observe the clinical effect of Tongmai Kaibi Decoction combined with Compound Danshen Dropping Pills and western medicine for stable angina pectoris of coronary heart disease of qi stagnation and blood stasis type.Methods:A total of 94 cases of patients with stable angina pectoris of coronary heart disease of qi stagnation and blood stasis type were randomly divided into the control group and the combination group,with 47 patients in each group.Both groups were treated with routine western medicines for antiplatelet and regulating lipid and Compound Danshen Dropping Pills,and the combination group was additionally treated with Tongmai Kaibi Decoction.Both groups were treated for 2 months.Before and after treatment,traditional Chinese medicine syndrome scores were assessed;angina pectoris attack frequency,angina pectoris duration,heart rates,blood pressure and ECG-related indexes of patients were recorded;left ventricular end-systolic volume index(LVESVI),left ventricular end-diastolic volume index(LVEDVI)and left ventricular ejection fraction(LVEF)were detected by Color Doppler Ultrasound System;the levels of soluble intercellular adhesion molecule-1(sICAM-1),interleukin-18(IL-18),interleukin-6(IL-6),glutathione peroxidase(GSH-Px),myeloperoxidase(MPO),high mobility group protein B1(HMGB1),malondialdehyde(MDA),and superoxide dismutase(SOD)were detected.Results:After treatment,the total effective rate and the total clinical effective rate of electrocardiogram in the combination group were higher than those in the control group(P＜0.05).The scores of chest pain,chest tightness,palpitation,shortness of breath,fatigue and lack of strength in the two groups were decreased when compared with those before treatment(P＜0.05),and the scores of chest pain,chest tightness,palpitation,shortness of breath,fatigue and lack of strength in the combination group were lower than those in the control group(P＜0.05).When compared with those before treatment,the frequency of angina pectoris attack in the two groups was decreased,the duration of angina pectoris was shortened,and the values of LVESVI and LVEDVI were decreased,and the LVEF values were increased,differences being significant(P＜0.05).The frequency of angina pectoris attack in the combination group was lower than that in the control group,the duration of angina pectoris was shorter than that in the control group,the LVEF value was higher than that in the control group,and the values of LVESVI and LVEDVI were lower than those in the control group,differences being significant(P＜0.05).Systolic blood pressure and diastolic blood pressure in the two groups were decreased when compared with those before treatment,heart rates were decreased when compared with those before treatment,the rise of ST segment and the change amplitude range of T-wave were increased when compared with those before treatment,differences being significant(P＜0.05).The systolic blood pressure and diastolic blood pressure in the combination group were lower than those in the control group,the heart rate was less than that in the control group,and the rise of ST segment and the change of T-wave were more significant than those in the control group,differences being significant(P＜0.05).The levels of sICAM-1,IL-18,and IL-6 in the two groups were decreased when compared with those before treatment(P＜0.05),and the levels of sICAM-1,IL-18,and IL-6 in the combination group were lower than those in the control group(P＜0.05).MDA levels in the two groups were decreased when compared with those before treatment,and the levels of SOD and GSH-Px were increased when compared with those before treatment,differences being significant(P＜0.05).The MDA level in the combination group was lower than that in the control group,and the levels of SOD and GSH-Px were higher than those in the control group,differences being significant(P＜0.05).The levels of MPO and HMGB1 in the two groups were decreased when compared with those before treatment(P＜0.05),and the levels of MPO and HMGB1 in the combination group were lower than those in the control group(P＜0.05).Conclusion:On the basis of routine western medicine and Compound Danshen Dropping Pills,the additional application of Tongmai Kaibi Decoction for patients with stable angina pectoris of coronary heart disease of qi stagnation and blood stasis type can effectively improve heart function,reduce inflammatory responses,inhibit oxidative stress and relieve clinical symptoms.
Objective:To observe the curative effect of Zhike Huatan Decoction combined with ambroxol hydrochloride for acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with type Ⅱ respiratory failure,and its effect on levels of ambroxol hydrochloride and phospholipase A2(PLA2)in serum.Methods:A total of 114 AECOPD patients with type Ⅱ respiratory failure were selected and divided into the control group and the treatment group according to the random number table method,with 59 cases in each group.Both groups received routine symptomatic treatment;the control group additionally received Ambroxine Hydrochloride Injection,and the treatment group received Zhike Huatan Decoction based on the treatment of the control group.Both groups received continuous treatment for 2 weeks.The clinical effects and incidence of adverse reactions were observed between two groups.The changes in levels of pulmonary function[forced expiratory volume(FEV1),forced vital capacity(FVC),and peak expiratory flow rate(PEF)],blood gas analysis[arterial oxygen partial pressure(PaO2),and carbon dioxide partial pressure(PaCO2)],inflammatory factors[C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)]and PLA2 levels in serum were compared before and after treatment in the two groups.Results:The total effective rate was 96.61%in the treatment group,and 83.64%in the control group,the difference being significant(P＜0.05).After treatment,the values of FEV1,FVC,and PEF in the two groups were increased when compared with those before treatment(P＜0.05),and the values of FEV1,FVC,and PEF in the treatment group were higher than those in the control group(P＜0.05).After treatment,the PaO2 values in the two groups were increased when compared with those before treatment(P＜0.05),and the PaCO2 values were decreased when compared with those before treatment(P＜0.05).The PaO2 value in the treatment group was higher than that in the control group(P＜0.05),and the PaCO2 value was lower than that in the control group(P＜0.05).After treatment,the levels of CRP,TNF-α,and PLA2 in serum in the two groups were decreased when compared with those before treatment(P＜0.05),and the levels of CRP,TNF-α,and PLA2 in serum in the treatment group were lower than those in the control group(P＜0.05).Conclusion:The combination of Zhike Huatan Decoction and ambroxol hydrochloride for AECOPD complicated with type Ⅱ respiratory failure has significant clinical effects,which can reduce inflammatory reactions,and effectively improve lung function and blood gas indicators,with high treatment safety.
Objective:To observe the clinical effect of musculoskeletal ultrasound-guided overall acupotomy release combined with radial extracorporeal shock wave on periarthritis of shoulder in adhesive phase.Methods:A total of 92 cases of patients with periarthritis of shoulder in adhesion phase were divided into the observation group and the control group according to the random number table method,with 46 cases in each group.The control group was treated with routine overall acupotomy release combined with radial extracorporeal shock wave,and the observation group was treated with musculoskeletal ultrasound-guided overall acupotomy release combined with radial extracorporeal shock wave.Both groups were treated continuously for 3 weeks.McGill pain scores,modified Constant-Murley Shoulder Function Scale(CMS)scores and shoulder range of motion were compared before and after treatment between the two groups.The clinical effects and the incidence of adverse reactions were compared between the two groups.Results:The cure rate was 80.43%in the observation group,higher than that of 60.87%in the control group(P＜0.05).After treatment,the McGill pain scores of Present Pain intensity(PPI),Visual Analogue Scale(VAS)and Pain Rating Index(PRI)in the two groups were decreased when compared with those before treatment(P＜0.05),and the above indexes in the observation group were lower than those in the control group(P＜0.05).After treatment,modified CMS scores and the shoulder range of motion including anterior flexion,upward lifting,abduction,backward extension,internal rotation and external rotation in the two groups were increased when compared with those before treatment(P＜0.05),and the above indexes in the observation group were higher than those in the control group(P＜0.05).No adverse reaction occurred in the two groups.Conclusion:Musculoskeletal ultrasound-guided overall acupotomy release combined with radial extracorporeal shock wave for periarthritis of shoulder in adhesive phase can effectively reduce the pain of patients,improve the range of motion and function of shoulder joints and enhance the clinical effect,with high safety.
Objective:To observe the clinical effect of point injection of methylprednisolone combined with basic treatment on patients with acute severe asthma attack and the effects on their lung function and quality of life.Methods:A total of 80 cases of patients with acute severe asthma attack were selected as the study objects and divided into the control group and the trail group according to the random number table method,with 40 cases in each group.On the basis of maintaining the conventional Chinese and western medicine regimen,The control group additionally received intravenous injection of Methylprednisolone Sodium Succinate for Injection,and the trial group was additionally treated with point injection of Methylprednisolone Sodium Succinate for Injection.Clinical effects and the incidence of adverse reactions were compared between the two groups.The lung function indicators and the scores of the Asthma Control Test(ACT)and St.George's Respiratory Questionnaire(SGRQ)were compared between the two groups before and after treatment.Results:The total effective rate was 95.00%in the trial group,higher than that of 80.00%in the control group(P＜0.05).After treatment,peak expiratory flow(PEF),the forced expiratory volume in one second(FEV1),and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)in the two groups were increased(P＜0.05),and the above three indexes in the trial group were higher than those in the control group(P＜0.05).After treatment,the SGRQ scores in the two groups were decreased(P＜0.05),and the ACT scores were increased(P＜0.05);the SGRQ score in the trial group was lower than that in the control group(P＜0.05),and the ACT score in the trial group was higher than that in the control group(P＜0.05).The duration of asthma and hospitalization time in the trial group were shorter than those in the control group(P＜0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions(P＞0.05).Conclusion:For patients with acute severe asthma attack,point injection of methylprednisolone combined with basic treatment can enhance clinical effects,rapidly relieve the symptoms of acute attack,recover the lung function,and improve quality of life without any increase in adverse reactions.
Wuzhi Decoction from Wen Bing Tiao Bian(Systematic Differentiation of Warm Diseases)is a classic formula in which medicine and food are from the same source.It is widely used in the clinical treatment of externally-contracted diseases,thirst,digestive system diseases,respiratory system diseases and infectious diseases.Modern studies have found that Wuzhi Decoction has pharmacological effects such as antioxidant free radicals,liver protection,anti-inflammation,heat-relieving and cooling.The authors systematically summarized the clinical application and therapeutic mechanism of Wuzhi Decoction in order to provide more references for clinical application of it.
Nephrogenic edema is caused by various primary or secondary kidney diseases,which seriously affects the daily life and health of patients.Chinese medicine believes spleen-kidney deficiency is the root of nephrogenic edema,and that internal retention of water is the branch,and he also thinks that the emphasis of its treatment is to promote urination.A large number of studies,which have been conducted on urination-promoting compound prescriptions represented by Wuling Powder,Zhuling Decoction,Zhenwu Decoction and their modified ones,showed a significant therapeutic on nephrogenic edema.The urination-promoting Chinese herbs that are used alone,such as Poria,Polyporus,Alismatis Rhizoma and Atractylodis Macrocephalae Rhizoma,can reduce the retention of water and sodium by increasing the electrolyte discharge and the expression of aquaporin,and can reduce the levels of inflammatory factors,resist apoptosis and resist renal fibrosis to relieve kidney injury and protect kidney function.The authors systematically summarize the contents of the researches on using Chinese herbs to treat nephrogenic edema,which aims to provide more reference for the treatment of the disease.
Objective:To observe the clinical effect of Huotan Kaiqiao Decoction combined with warm needling on vascular dementia(VD)of phlegm turbidity obstructing the orifices type.Methods:A total of 86 cases of VD patients of phlegm turbidity obstructing the orifices type were selected and divided into the control group and the combination group according to different treatment methods,with 43 cases in each group,and 3 cases dropped out in each group.The control group was treated with routine western medicine,and the combination group was additionally treated with Huotan Kaiqiao Decoction combined with warm needling based on the treatment of the control group.Both groups were continuously treated for 3 months.Clinical effects were evaluated in the two groups.Traditional Chinese medicine syndrome scores,the scores of cognitive function and activities of daily living,and serum indicators were compared between the two groups before and after treatment.Results:The total effective rate was 90.00%in the combination group,higher than that of 70.00%in the control group(P＜0.05).After treatment,the scores of main symptoms and secondary symptoms in the two groups were decreased when compared with those before treatment(P＜0.05),and the scores of main symptoms and secondary symptoms in the combination group were lower than those in the control group(P＜0.05).After treatment,the scores of cognitive function and activities of daily living in the two groups were increased when compared with those before treatment(P＜0.05),and the above scores in the combination group were higher than those in the control group(P＜0.05).After treatment,the levels of interleukin-18(IL-18),homocysteine(Hcy),and vascular endothelial growth factor(VEGF)in serum in the two groups were decreased when compared with those before treatment,and the above three levels in the combination group were lower than those in the control group(P＜0.05).The levels of brain derived neurotrophic factor(BDNF)in serum in the two groups were increased when compared with those before treatment,and the level in the combination group was higher than that in the control group(P＜0.05).Conclusion:For VD of phlegm turbidity obstructing the orifices type,Huotan Kaiqiao Decoction combined with warm needling can improve clinical symptoms,cognitive function,and activities of daily living,reduce inflammatory reactions,and promote the recovery of neurological function.
Objective:To observe the clinical effect of Bushen Shugan Huoxue Formula combined with western medicine for intrauterine adhesions with syndrome of liver constrain and kidney deficiency complicated with blood stasis.Methods:A total of 96 cases of patients with intrauterine adhesions with syndrome of liver constrain and kidney deficiency complicated with blood stasis were divided into the control group and the trial group according to the random number table method,with 48 cases in each group.Both groups underwent hysteroscopic separation of uterine adhesions;the control group was treated with routine western medicine,and the trial group was additionally treated with Bushen Shugan Huoxue Formula based on the treatment of the control group.Traditional Chinese medicine(TCM)syndrome scores,the scores of intrauterine adhesions(IUA),and endometrial thickness were compared before and after treatment between the two groups.Clinical effects and the incidence of adverse reactions were evaluated in the two groups.During the 1-year follow-up,the pregnancy rate after the operation was compared between the two groups.Results:After treatment,the total effective rate in the trial group was higher than that in the control group(P＜0.05).TCM syndrome scores and the IUA scores in the two groups were decreased when compared with those before treatment(P＜0.05),and endometrial thickness was increased(P＜0.05).TCM syndrome score and the IUA score in the trial group were lower than those in the control group(P＜0.05),and endometrial thickness in the trial group was higher than that in the control group(P＜0.05).During the 1-year follow-up,the pregnancy rate in the trial group was higher than that in the control group(P＜0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Bushen Shugan Huoxue Formula combined with western medicine has a definite curative effect on intrauterine adhesions with syndrome of liver constrain and kidney deficiency complicated with blood stasis.It can increase endometrial thickness of patients and improve intrauterine adhesions with high safety.
Objective:To observe the clinical effect of nasal feeding with Chaishao Chengqi Decoction combined with raw rhubarb enema for severe acute pancreatitis complicated with enteroparalysis.Methods:A total of 72 cases of patients with severe acute pancreatitis complicated with enteroparalysis were divided into the control group and the treatment group according to the random number table method,with 36 cases in each group.The control group was treated with routine western medicine,and the treatment group was additionally treated with nasal feeding with Chaishao Chengqi Decoction combined with raw rhubarb enema based on the treatment of the control group.Both groups were treated for 7 days.The clinical effects and recovery time of gastrointestinal function were compared between the two groups.Before and after treatment,traditional Chinese medicine(TCM)syndrome scores,and levels of blood calcium,inflammatory indexes and intestinal flora were compared between the two groups.Results:During treatment,2 cases were lost and 34 cases were completed in the control group;2 cases were lost and 34 cases were completed in the treatment group.The total effective rate was 91.18%in the treatment group,higher than that of 70.59%in the control group(P＜0.05).The relief time of abdominal distension and abdominal pain,recovery time of bowel sounds recovering to normal,first spontaneous defecation time,first spontaneous exhaust recovery time,fasting time,and time of intra-abdominal hypertension recovering to normal were all shorter than those in the control group(P＜0.05).After treatment,the TCM syndrome scores,and levels of white blood cell count,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)in the two groups were decreased when compared with those before treatment(P＜0.05),and blood calcium levels were increased(P＜0.05).After treatment,TCM syndrome scores,and levels of white blood cell count,CRP,TNF-α and IL-6 were lower than those in the control group(P＜0.05),and the blood calcium level was higher than that in the control group(P＜0.05).After treatment,the levels of Enterococcus and Escherichia coli in the two groups were decreased when compared with those before treatment(P＜0.05),and the levels of Lactobacillus and Bifidobacterium were increased(P＜0.05).After treatment,the levels of Enterococcus and Escherichia coli in the treatment group were lower than those in the control group(P＜0.05),and the levels of Lactobacillus and Bifidobacterium were higher than those in the control group(P＜0.05).Conclusion:Nasal feeding with Chaishao Chengqi Decoction combined with raw rhubarb enema for severe acute pancreatitis complicated with enteroparalysis can accelerate the recovery of gastrointestinal function,reduce inflammatory responses,improve intestinal flora,and have a significant clinical effect.
Objective:To observe the clinical effect of Zuogui Pills combined with Cangfu Daotan Decoction for infertility caused by polycystic ovary syndrome(PCOS)with phlegm-damp obstruction syndrome.Methods:A total of 96 cases of patients with infertility caused by PCOS with phlegm-damp obstruction syndrome were divided into the control group and the combination group according to the random number table method,with 48 cases in each group.The control group was given routine treatment,and the combination group was additionally treated with modified Zuogui Pills combined with Cangfu Daotan Decoction based on the treatment of the control group.Traditional Chinese medicine(TCM)symptom scores and levels of sex hormones in serum were compared before and after treatment between the two groups,and the clinical effects and pregnancy rates were compared between the two groups.Results:After treatment,the scores of main and secondary symptoms and the total TCM syndrome scores in the two groups were decreased(P＜0.05),and the above scores in the combination group were lower than those in the control group(P＜0.05).The total effective rate was 95.83%in the combination group,higher than that of 79.17%in the control group(P＜0.05).The natural pregnancy rate was 45.83%in the combination group,higher than that of 25.00%in the control group(P＜0.05).After treatment,the levels of estradiol(E2),follicle-stimulating hormone(FSH)and progesterone(P)were increased(P＜0.05),and the levels of luteinizing hormone(LH)was decreased(P＜0.05);the levels of E2,FSH and P in the combination group were higher than those in the control group(P＜0.05),and the levels of LH was lower than those in the control group(P＜0.05).Conclusion:Zuogui Pills combined with Cangfu Daotan Decoction for infertility caused by polycystic ovary syndrome(PCOS)with phlegm-damp obstruction syndrome can improve clinical symptoms,regulate the levels of sex hormones and increase the spontaneous pregnancy rate.
Objective:To observe the clinical effect of the therapy of Buyang Huoxue Prescription combined with Sacubitril Valsartan Sodium Tablets on patients with acute exacerbation of chronic heart failure of yang qi depletion and blood stasis type.Methods:Using retrospective analysis,the clinical data of 84 patients with acute exacerbation of chronic heart failure of yang qi depletion and blood stasis type were analyzed,and the 84 patients were divided into the control group and the observation group according to different treatment methods,with 42 cases in each group.Both groups were treated with western medicine such as Sacubitril Valsartan Sodium Tablets,and the observation group was additionally treated with Buyang Huoxue Prescription.The traditional Chinese medicine(TCM)syndrome scores,the 6-minute walk distance,heart function indexes,including left ventricular ejection fraction,left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVESD),the myocardial enzyme,including N-terminal pro-brain natriuretic peptide(NT-proBNP),and the indexes of inflammatory factors,including interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)were compared before and after treatment between the two groups;the clinical effects and incidence of adverse reactions were compared between the two groups.Results:After 3 months of treatment,the total effective rate in the observation group was higher than that in the control group(P＜0.05).The TCM syndrome scores in the two groups were decreased when compared with those before treatment,and the 6-minute walk distance in the two groups were increased when compared with those before treatment,differences being significant(P＜0.05).The TCM syndrome score in the observation group was lower than that in the control group,and the 6-minute walk distance was longer than that in the control group,differences being significant(P＜0.05).The LVEF values in both groups were increased when compared with those before treatment,and the values of LVESD and LVEDD in both groups were decreased when compared with those before treatment,differences being significant(P＜0.05).The LVEF value in the observation group was higher than that in the control group,and the values of LVESD and LVEDD were lower than those in the control group,differences being significant(P＜0.05).The levels of NT-proBNP,IL-6 and hs-CRP in both groups were decreased when compared with those before treatment(P＜0.05),and the above levels in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).Conclusion:The therapy of Buyang Huoxue Prescription combined with Sacubitril Valsartan Sodium Tablets has a significant curative effect on patients with acute exacerbation of chronic heart failure of yang qi depletion and blood stasis syndrome type,which can not only mitigate the symptoms earlier,but also improve the heart function,and reduce myocardial injuries with good safety.
Objective:To observe the clinical effect of Feilike Mixtures combined with western medicine on elderly patients with cough variant asthma(CVA).Methods:A total of 98 cases of CVA patients were divided into the control group and the observation group according to the random number table method,with 49 cases in each group.The control group was treated with conventional western medicine,and the observation group was additionally treated with the oral administration of Feilike Mixtures based on the treatment of the control group.Both groups were continuously treated for half a month.Clinical effects were evaluated in the two groups.Traditional Chinese medicine(TCM)syndrome scores,the lung function,and the levels of inflammatory factors in serum were compared between the two groups before and after treatment.The incidence of adverse reactions was observed.Results:The total effective rate was 95.92%in the observation group,higher than that of 81.63%in the control group(P＜0.05).After treatment,TCM scores in the two groups were decreased when compared with those before treatment(P＜0.05),and each TCM syndrome score in the observation group was lower than that in the control group(P＜0.05).After treatment,peak expiratory flow(PEF),the forced expiratory volume in one second(FEV1),and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)in the two groups were increased when compared with those before treatment(P＜0.05),and the above three levels in the observation group were higher than those in the control group(P＜0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-8(IL-8)in serum in the two groups were increased when compared with those before treatment(P＜0.05),and the levels of TNF-α,IL-6,and IL-8 in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference being significant(χ2=4.009,P=0.045).Conclusion:Feilike Mixtures combined with western medicine has good clinical effects on elderly CVA patients,which can improve clinical symptoms and the lung function and reduce inflammatory factors levels and adverse reactions.
Objective:To observe the clinical study on Wenjing Qiangyao Mixture for lumbar disc herniation of wind-cold obstruction type.Methods:A total of 130 patients with lumbar disc herniation were selected and divided into the trial group and the control group,with 65 cases in each group.The trial group was given Wenjing Qiangyao Mixture for treatment,and the control group was treated with Fengshi Gutong Capsules.The clinical effects and incidence of adverse reactions in both groups were observed;the changes of lumbar pain,including scores of Visual Analogue Scale(VAS)and Japanese Orthopaedic Association(JOA),traditional Chinese medicine(TCM)syndrome scores,and levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),superoxide dismutase(SOD),nitric oxide(NO),cyclooxygenase-2(COX-2),endothelin-1(ET-1),prostaglandin E2(PGE2)and interleukin-1β(IL-1β)were compared between the two groups before and after treatment.Results:The total clinical effective rate was 98.46%in the trial group and 80.00%in the control group,the difference being significant(P＜0.05).Three days,ten days and twenty days after treatment,the VAS scores in the two groups were lower than those before treatment,and the JOA scores were higher than those before treatment,the difference being significant(P＜0.05).After treatment,the TCM syndrome scores of heavy pain in the lumbar,cold-induced aggravation,great pain when moving and limited movement in both groups were decreased when compared with those before treatment(P＜0.05),and the above scores in the trial group were lower than those in the control group(P＜0.05).After treatment,the levels of serum inflammatory factors,including IL-6,NO and TNF-α in both groups were decreased when compared with those before treatment(P＜0.05),the SOD levels were increased when compared with those before treatment(P＜0.05);the levels of IL-6,NO and TNF-α in the trial group were lower than those in the control group(P＜0.05),and the SOD level was higher than that in the control group(P＜0.05).After treatment,the levels of serum pain mediators,including COX-2,ET-1,PGE2 and IL-1β in both groups were decreased when compared with those before treatment(P＜0.05),and the above levels in the trial group were lower than those in the control group(P＜0.05).There was no obvious adverse reaction in the two groups during treatment.Conclusion:Wenjing Qiangyao Mixture has a good curative effect on lumbar disc herniation,which can effectively reduce the lumbar pain of patients,and improve the lumbar function with good safety.
Objective:To observe the clinical effect of the external application of Zhitong Xiaoyan Ointment combined with the sequential use of Hirudoid on postoperative limb stasis and edema of arteriovenous fistula.Methods:A total of 80 cases of patients with postoperative limb stasis and edema of arteriovenous fistula were selected and divided into the observation group and the control group according to the random number table method,with 40 cases in each group.The observation group was treated with the external application of Zhitong Xiaoyan Ointment combined with the sequential use of Hirudoid cream,and the control group was treated with Hirudoid cream,twice a day.Both groups were additionally treated with far-infrared radiation for 40 minutes each time,and all treatments continued for 6 days.The degree of limb edema,the area and time of disappearance of skin stasis and edema,Visual Analogue Scale(VAS)scores and the levels of serum high-sensitivity C-reactive protein(hs-CRP)were compared between the two groups before and after treatment.Results:After treatment,the degree of limb edema in the two groups were decreased(P<0.05),and the improvement in the observation group was better than that in the control group(P<0.05).After 48 hours of treatment,the area of skin stasis and edema in the two groups were decreased,and the area in the observation group was smaller than that in the control group(P<0.05).The time of disappearance of skin stasis and edema in the observation group was shorter than that in the control group(P<0.05).After treatment,VAS scores in the two groups were decreased(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05).After treatment,hs-CRP in the two groups were decreased(P<0.05),and the level in the observation group was lower than that in the control group(P<0.05).Conclusion:The early application of external application of Zhitong Xiaoyan Ointment combined with the sequential use of Hirudoid cream can effectively relieve stasis,edema,and pain in patients after the surgery of arteriovenous fistula,improve the body's micro-inflammatory state,and improve their postoperative comfort and satisfaction.
Objective:To observe the clinical effect of alternate treatment with Chinese medicine prescriptions for refractory duodenal ulcer.Methods:A total of 62 cases of patients with refractory duodenal ulcer of positive helicobacter pylori(Hp)complicated with liver depression and spleen deficiency were selected as the study objects,and were divided into the control group and the trial group according to the random number table method,with 31 cases in each group.The control group was treated with western medicine of Amoxicillin combined with Rabeprazole,and the trial group was additionally given alternate treatment with Chinese medicine prescriptions of Yuyang Prescription and Tiaoshen Prescription based on the treatment of the control group.Both groups were treated for 6 weeks.Traditional Chinese medicine(TCM)syndrome scores were compared before and after treatment between the two groups,and the curative effect of gastroscopy,Hp eradication rates and adverse reactions were compared between the two groups.Results:After treatment,the effective rate was 83.33%in the trial group,higher than that of 56.67%in the control group(P＜0.05).After treatment,the total effective rate was 96.67%in the trial group and 93.33%in the control group,there being no significant difference between the two groups(P＞0.05).After treatment,the scores of TCM syndromes and the total scores in the trial group were decreased(P＜0.05),and the scores of TCM syndromes including distending pain in hypochondrium and abdomen,depression and anger,poor appetite,sloppy stool,acid reflux,and gastric upset as well as the total scores in the control group were decreased(P＜0.05);the scores of TCM syndromes and the total score in the trial group were lower than those in the control group(P＜0.05).There was no significant difference being found in the comparison of Hp eradication rates and incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The alternate treatment with Chinese medicine prescriptions for refractory duodenal ulcer can improve the clinical symptoms of patients and the clinical effect.
Objective:To analyze the distribution rules of traditional Chinese medicine syndrome(TCM)types of peritoneal dialysis-associated peritonitis(PDPA)and the influencing factors of PDPA.Methods:A total of 244 patients who received peritoneal dialysis were retrospectively selected as the study objects,and divided into the peritonitis group and the non-peritonitis group according to whether PDPA occurred,with 74 and 170 cases in each group,respectively.The general data and laboratory indexes were compared between the two groups;the distribution rules of TCM syndrome types and influencing factors of PDPA in the peritonitis group were analyzed.Results:There was no significant difference being found in the comparisons of age,gender,the age of receiving peritoneal dialysis,body mass index(BMI)and complicated with diabetes between the two groups(P＞0.05).The level of education in the peritonitis group was higher than that in the non-peritonitis group(P＜0.05),the level of serum transferrin(TRF)was higher than that in the non-peritonitis group(P＜0.05),and the level of albumin(Alb)was lower than that in the non-peritonitis group(P＜0.05).In the pathogenic bacteria culture of peritoneal dialysis fluid in the peritonitis group,Klebsiella pneumoniae and Streptococcus salivarius were commonly seen;the common causes were irregular disinfection or poor contact,gastrointestinal dysfunction,respiratory tract infection,etc.The syndrome of deficiency in origin of clinical PDPA mainly includes the syndrome of spleen-kidney deficiency and syndrome of spleen-kidney yang deficiency,and the syndrome of excess in superficiality is usually the syndrome of dampness turbidity.Multifactorial logistic regression analysis showed that the high level of education and Alb were protective factors for the occurrence of PDAP,and high TRF was a risk factor.Conclusion:In clinical,the syndrome of deficiency in origin of PDPA mainly includes the syndrome of spleen-kidney deficiency and syndrome of spleen-kidney yang deficiency,and the syndrome of excess in superficiality is usually the syndrome of dampness turbidity.The high level of education and Alb were protection factors for the occurrence of PDAP,and high TRF was a risk factor.
