目的:探讨利巴韦林喷雾剂联合小儿豉翘清热颗粒对手足口病(HFMD)患儿外周血T淋巴细胞亚群、血清免疫球蛋白指标和炎性因子的影响.方法:选择2019年8月至2022年6月期间我院收治的HFMD患儿90例作为考察对象.按照双色球法将患儿分为对照组和研究组,各为45例.在常规治疗的基础上,对照组接受利巴韦林喷雾剂治疗,研究组接受利巴韦林喷雾剂联合小儿豉翘清热颗粒治疗.观察两组疗效、临床症状、血清免疫球蛋白指标、外周血T淋巴细胞亚群指标和炎性因子的变化,比较两组不良反应发生率.结果:与对照组的临床总有效率相比,研究组的明显更高(P＜0.05).研究组的退热时间、皮疹消失时间、口腔溃疡消退时间均短于对照组(P＜0.05).治疗后,两组CD3+、CD4+、CD4+/CD8+升高,CD8+下降(P＜0.05).治疗后,研究组CD3+、CD4+、CD4+/CD8+高于对照组,CD8+低于对照组(P＜0.05).治疗后,两组血清免疫球蛋白(Ig)指标:IgA、IgM、IgG升高(P＜0.05).治疗后,研究组IgA、IgM、IgG高于对照组(P＜0.05).治疗后,两组白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)下降(P＜0.05).治疗后,研究组TNF-α、IL-6、IL-1β低于对照组(P＜0.05).两组不良反应发生率组间对比差异不显著(P＞0.05).结论:利巴韦林喷雾剂联合小儿豉翘清热颗粒治疗HFMD患儿,可有效调节炎性因子水平和免疫功能,促进临床症状改善.

Objective This study was to examine the relationship between socioeconomic status and the incidence and mortality of non-Hodgkin lymphoma (NHL). Methods We compared the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and the ASMR to ASIR ratio (MIR) at national and regional levels and studied the correlation between the MIR and the human development index (HDI) in 2012 and 2018. Results The highest ASIR was in North America in 2012 and in Australia in 2018, and the lowest ASIR was in Central and South Asia in both 2012 and 2018. The highest ASMR was in North Africa in both 2012 and 2018, and the lowest ASMR was in Eastern Asia and South-Central Asia in 2012 and in South-Central Asia in 2018. The lowest MIR was in Australia in both 2012 and 2018, and the highest MIR was in Western Africa in both 2012 and 2018. HDI was strongly negatively correlated with MIR ( r : −0.8810, P <0.0001, 2012; r : −0.8895, P <0.0001, 2018). Compared to the 2012 data, the MIR in the intermediate HDI countries significantly deceased and the HDI in low and high HDI countries significantly increased in 2018. Conclusion The MIR is negatively correlated with HDI. Increasing the HDI in low and intermediate HDI countries may reduce the MIR and increase the survival of patients with NHL.

Objective: To investigate the evaluation value of serum interleukin-6（IL-6）, C-reactive protein to albumin ratio（CAR）combined with neutrophil to lymphocyte ratio（NLR） in the condition and prognosis of neonatal respiratory distress syndrome（NRDS）.Methods: 102 children with NRDS（NRDS group） who were admitted to our hospital from December 2020 to April 2022 were selected,and they were divided into mild subgroup with 23 cases, moderate subgroup with 38 cases and severe subgroup with 41 cases according to the severity of the disease. According to the outcome at 28 days after treatment, they were divided into death group with 37 cases and survival group with 65 cases, and 57 healthy newborns（control group） were selected during the same period. Serum IL-6, CAR and NLR were detected, the influencing factors of poor prognosis in children with NRDS were analyzed by multivariate Logistic regression and the evaluation value of serum IL-6, CAR and NLR for poor prognosis in children with NRDS was analyzed by receiver operating characteristic（ROC） curve. Results: Serum IL-6, CAR and NLR in the NRDS group were higher than those in the control group（all P＜0.001）.Serum IL-6, CAR and NLR were increased successively in mild, moderate and severe subgroups（all P＜0.001）. Serum IL-6, CAR and NLR in the death group were higher than those in the survival group（all P＜0.001）. Multivariate Logistic regression analysis showed that gestational age and the increase of 5min Apgar score were independent protective factors for poor prognosis in children with NRDS, and the increase of IL-6, CAR and NLR were independent risk factors（all P＜0.05）. ROC curve analysis showed that the area under curve（AUC） of the combined evaluation of serum IL-6, CAR and NLR for poor prognosis of children with NRDS was greater than that of the independent evaluation of each indicator（all P＜0.05）. Conclusion: The increase of serum IL-6, CAR and NLR in children with NRDS is closely related to disease exacerbation and poor prognosis, and the combination of serum IL-6 and CAR with NLR has a higher value in evaluating poor prognosis in children with NRDS.

目的:分析和对比莫匹罗星与金霉素治疗儿童脓疱疹的临床效果,为脓疱疹患儿找到一种高效的治疗方案.方法:选择60例在我院接受治疗的脓疱疹患儿作为研究对象,患儿最早收治时间为2019年1月,最晚为2020年1月,入组后,采用随机双盲法对其进行分组,分为研究组和对照组,两组例数均为30例,研究组采用莫匹罗星治疗,对照组采用金霉素治疗,对比两组患儿脓疱疹消退时间、皮损愈合时间、住院时间、治疗期间的不良反应发生率及治疗总有效率.结果:研究组患儿脓疱疹消退时间(1.09±0.43)d、皮损愈合时间(3.58±1.12)d、住院时间(5.68±1.34)d均显著短于对照组(4.64±1.02)d、(6.27±1.34)d、(7.55±1.69)d,研究组患儿治疗总有效率(97％)显著高于对照组(80％),两组对比具有统计学意义(P<0.05);研究组、对照组患儿治疗期间的不良反应发生率分别为7％、10％,对比无统计学意义(P>0.05).结论:对脓疱疹患儿采用莫匹罗星治疗,可取得良好的治疗效果,不仅能促进患儿脓疱疹消退和皮损愈合,还能缩短患儿整体预后周期,且不良反应发生率较低,因此,其是一种安全、高效的治疗方案.