目的 探讨胶质瘤中M2c型肿瘤相关巨噬细胞(tumor associated macrophages,TAM)与肿瘤微血管密度(microvessel density,MVD)和细胞增殖之间的关系.方法 纳入40份病理结果为胶质瘤的石蜡包块,采用免疫组织化学SP法检测脑胶质瘤组织中CD163、CD34-MVD、Ki-67表达及其相关性,并探讨其与各项临床病理特征的关系.结果 低级别与高级别胶质瘤分组间CD163、CD34-MVD和Ki-67表达水平均有显著性差异(P<0.05);CD34-MVD和Ki-67表达在病人年龄分组间有显著差异(P<0.05),而在性别分组间无显著差异(P>0.05).进一步分析发现:脑胶质瘤中CD163表达水平与CD34-MVD、Ki-67表达水平均呈正相关(P<0.05).结论 肿瘤微环境中浸润的M2c型TAM与胶质瘤微血管形成和细胞增殖关系密切,CD163、CD34-MVD、Ki-67三者联合检测有利于评估肿瘤的恶性程度,并为胶质瘤临床治疗药物研发提供分子生物学依据.

随着生物信息学技术的进步,多项研究揭示了非编码RNA(ncRNA)在发育和基因表达中发挥重要的调控作用,并参与肿瘤的增殖、凋亡及侵袭转移等多个生物学过程.本文主要就目前广泛研究的微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)在垂体腺瘤(PAs)进展中的调控作用进行概述,并探讨其在临床诊疗过程中的应用价值和研究前景.

Glioma is a common tumor in the central nervous system. Because the natural immunosuppression of tumor microenvironment is conducive to tumor growth, transformation and migration, the traditional treatment has little effect and is difficult to make a breakthrough. Glioma-associated microglia and macrophage (GAM), an important part of brain tumor microenvironment, plays a more and more key role in tumor progression and regulation of anti-tumor immune response. This article reviews the latest progress of the source, recruitment, polarization and the role in development of gliomas as well as potential therapeutic targets of gliomas.