Abstract Music therapy, known for its profound impact on human emotions and physiology, has gained increasing attention for its applications in medical settings, particularly in surgery. This study conducted a bibliometric analysis of publications on the application of music therapy in surgery from 2009 to 2023, utilizing the Web of Science Core Collection (WoSCC) as the primary database. A total of 479 publications were analyzed using VOSviewer, CiteSpace, Microsoft Excel, and online bibliometric tools. Findings indicate a steady increase in annual publications since 2009, peaking in 2021. The USA leads global research efforts with 31.7% of publications, followed by China (17.7%) and Italy (10%). Harvard University was identified as the top contributing institution, while the Journal of Perianesthesia Nursing was the primary publishing journal, and the Cochrane Database of Systematic Reviews was the highest co-cited journal. Cao Hua contributed the most publications, and Nilsson U was identified as the most co-cited author (n = 131). Keyword analysis highlighted anxiety, therapy, music therapy, and pain as primary research trends. This study provides valuable insights into the evolving landscape of music therapy research in surgical contexts. Future efforts should focus on expanding interdisciplinary collaborations, exploring advanced technologies for personalized interventions, and investigating optimal implementation strategies to enhance the integration of music therapy into surgical practice.

Background:Smoking is a global public health concern, with approximately 1,245 billion smokers worldwide. It is associated with a range of health complications, including cardiovascular and respiratory diseases. Osteoporosis, characterized by reduced bone density and deterioration of bone tissue, has a global prevalence of 18.3%, with higher rates in women over the age of 50. Smoking has been recently associated with osteoporosis, potentially due to shared metabolic disorders or personal habits. This study aimed to investigate the association between smoking and osteoporosis in relation to all-cause mortality in a cohort from the United States. Methods:Data were sourced from the National Health and Nutrition Examination Survey (NHANES) database, which focuses on individuals aged 20 years and older from 2005-2010, 2013-2014, and 2017-2018, where femoral neck bone density testing was conducted. The participants were categorized on the basis of their self-reported smoking status and bone mineral density (BMD) measurements, following the World Health Organization criteria for osteoporosis. The covariates included age, sex, race, alcohol consumption, BMI, blood glucose levels, and other health indicators. Statistical analysis included ANOVA and chi-square tests for baseline characteristics, Kaplan-Meier survival analysis, and multivariate Cox regression analysis to assess hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. We divided the patients into four different groups via a cross-classification method on the basis of smoking status and whether they had osteoporosis. Results:This study included 19,400 participants, with significant differences in baseline characteristics across 4 groups (S-/OP+: nonsmokers with osteoporosis; S+/OP-: smokers without osteoporosis; S-/OP-: nonsmokers without osteoporosis; S+/OP+: smokers with osteoporosis). The overall average age was 53.1 years, and women accounted for 49.6% of the total population. The mortality rate due to all factors in the total population was 13.1%, with the highest S+/OP+ mortality rate. Participants with both a smoking history and osteoporosis had a 146% increase in all-cause mortality (HR: 2.46, 95% CI: 2.12-2.87) even after adjusting for confounding factors. The relative excess risk due to interaction (RERI) suggested a lack of statistical significance, whereas the attributable proportion (AP) indicated a synergistic effect between smoking and osteoporosis. Conclusions:This cohort study highlights the importance of managing and preventing smoking and osteoporosis to reduce the risk of all-cause mortality. The findings provide preliminary evidence of a synergistic effect between smoking and osteoporosis on all-cause mortality risk, emphasizing the need for proactive strategies for smoking cessation and close monitoring of risk factors in individuals with both conditions.

Intracranial solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare mesenchymal tumors with significant vascularization, often misdiagnosed as meningiomas. Surgical resection is the primary treatment, with postoperative radiotherapy increasingly recognized for its role in improving recurrence-free survival. However, standard radiotherapy regimens remain undefined. We retrospectively analyzed clinical data from 12 patients diagnosed with SFT/HPC who underwent surgical resection and postoperative intensity-modulated radiotherapy. Clinical information, imaging findings, treatment methods, and outcomes were reviewed. Surgical resection achieved complete or subtotal tumor removal in all cases. Postoperative radiotherapy was administered to 8 patients. During follow-up, 3 patients experienced tumor recurrence, necessitating reoperation, while 1 patient died due to complications. Those who received radiotherapy showed a trend towards reduced recurrence. Surgical resection remains the cornerstone of SFT/HPC treatment, with adjuvant radiotherapy potentially improving outcomes. However, individualized treatment strategies and long-term follow-up are crucial due to the tumor's propensity for recurrence. Further research is needed to optimize treatment approaches and enhance patient survival and quality of life.

Depression and osteoporosis are significant global health issues. Depression affects mental well-being and imposes social and economic burdens, while osteoporosis impacts bone health and raises fracture risk. However, their effects on cardiovascular disease (CVD) mortality and all-cause mortality remain unclear. This study examines their combined impact on cardiovascular and all-cause mortality. We used National Health and Nutrition Examination Survey data from 2005 to 2010, 2013 to 2014, and 2017 to 2018 (n = 19,282; weighted population 155,470,483). Depression was assessed via Patient Health Questionnaire-9, and osteoporosis through dual-energy X-ray absorptiometry scans. Mortality data came from the National Death Index. Participants were categorized into 4 groups based on depression and osteoporosis status. Cox models and Kaplan-Meier analysis were used to assess mortality risk. The primary outcomes were CVD mortality and all-cause mortality. During a median 122-month follow-up, there were 2384 all-cause deaths and 581 CVD deaths. The Dep+/OP+ group had the highest all-cause mortality risk (hazard ratio = 2.80, 95% confidence intervals: 1.92-4.08) and CVD mortality risk (hazard ratio = 2.03, 95% confidence intervals: 1.21-3.39). Compared to the Dep-/OP- group, the Dep-/OP+ and Dep+/OP- groups also had elevated risks. The combination of depression and osteoporosis significantly increases CVD and all-cause mortality risks, particularly in younger individuals and males. These conditions may share biological pathways that increase mortality risk, highlighting the need for integrated clinical management.

Music therapy, leveraging the profound influence of music on human emotions and physiology, has gained attention for its potential applications in medical settings, particularly in surgery. This study aims to conduct a comprehensive bibliometric analysis of music therapy's application in surgery. Publications related to application of music therapy in surgery from 2009 to 2023 were searched in the Web of Science Core Collection (WoSCC) databases. Bibliometric analysis was conducted using VOSviewer, CiteSpace, Microsoft Excel, and online bibliometrics websites. This study included 479 publications, with a steady increase in annual publications since 2009, peaking in 2021. The USA had the highest number of publications (n = 152, 31.7%), followed by China (85, 17.7%) and Italy (48, 10%). Harvard University emerged as the top research institution, while the Journal of Perianesthesia Nursing was the primary publishing journal, and the Cochrane Database of Systematic Reviews was the highest co-cited journal. Cao Hua had the highest number of studies, and Nilsson U (n = 131) was identified as the most co-cited author. Keyword analysis revealed anxiety, therapy, music therapy, and pain as primary research trends in recent years. This bibliometric study provides a comprehensive summary of the existing research landscape, highlighting progress, challenges, and opportunities in integrating music therapy into surgical practice.

BACKGROUND Simultaneous bilateral basal ganglia hemorrhage is an infrequent occurrence in medical literature. The etiology of bilateral basal ganglia intracerebral hemorrhage remains elusive, in contrast to that of unilateral basal ganglia hypertensive intracerebral hemorrhage, resulting in lack of consensus among scholars. Importantly, patients with uremia and cerebral hemorrhage, especially patients with large hematoma volumes, exhibit a markedly elevated mortality rate. Patients can benefit from implementation of positive and efficacious therapeutic approaches. CASE REPORT We present a clinical case involving a 42-year-old male patient who was admitted to the hospital in a comatose state. The initial head computed tomography scan revealed the presence of simultaneous basal ganglia hemorrhage; this phenomenon could potentially be attributed to the occurrence of cerebral hemorrhage induced by severe renal hypertension in individuals with uremia. The patient underwent emergency surgical intervention to evacuate the hematoma, followed by continuous blood purification treatment. Ultimately, these interventions have the potential to improve patient outcomes. CONCLUSIONS Incidence of bilateral basal ganglia hemorrhage is exceptionally rare and associated with an unfavorable prognosis, often resulting in mortality among individuals with severe underlying conditions or complications. The hematoma was successfully eliminated through the use of skull resection and neuroendoscopy techniques, resulting in favorable outcomes. The implementation of bedside continuous hemodialysis in patients with uremic cerebral hemorrhage can enhance therapeutic efficacy, thus warranting its recommendation for similar cases. Based on our observations, it is plausible that severe hypertension plays a contributory role in the development of simultaneous bilateral basal ganglia bleeding.

Music therapy, leveraging the profound influence of music on human emotions and physiology, has gained attention for its potential applications in medical settings, particularly in surgery. This study aims to conduct a comprehensive bibliometric analysis of music therapy's application in surgery. Publications related to application of music therapy in surgery from 2009 to 2023 were searched in the Web of Science Core Collection (WoSCC) databases. Bibliometric analysis was conducted using VOSviewer, CiteSpace, Microsoft Excel, and online bibliometrics websites. This study included 479 publications, with a steady increase in annual publications since 2009, peaking in 2021. The USA had the highest number of publications (n = 152, 31.7%), followed by China (85, 17.7%) and Italy (48, 10%). Harvard University emerged as the top research institution, while the Journal of Perianesthesia Nursing was the primary publishing journal, and the Cochrane Database of Systematic Reviews was the highest co-cited journal. Cao Hua had the highest number of studies, and Nilsson U (n = 131) was identified as the most co-cited author. Keyword analysis revealed anxiety, therapy, music therapy, and pain as primary research trends in recent years. This bibliometric study provides a comprehensive summary of the existing research landscape, highlighting progress, challenges, and opportunities in integrating music therapy into surgical practice.

Rationale:Meningiomas are mostly benign brain tumors with minimal malignant cases. Anaplastic meningioma has malignant morphological characteristics and a World Health Organization grade of III. Patient concerns:The present study reports a case of an occipital meningioma in a patient who initially chose observation and follow-up after diagnosis. The patient ultimately underwent surgery due to the enlargement of the tumor and the development of visual field defects after a decade of imaging follow-up. The postoperative pathology slides indicated the presence of an anaplastic meningioma (World Health Organization-grade III). Diagnoses:The patient's diagnosis was established through cranial magnetic resonance imaging, which revealed an irregular mixed mass in the right occipital region with isointense T1 and hypointense T2 signal, irregular lobulation, and a maximum diameter of approximately 5.4 cm. Heterogenous enhancement was observed in the contrast-enhanced scan. Interventions:The patient opted for surgical intervention to remove the tumor, and the pathology slides of the tumor sample confirmed the diagnosis of anaplastic meningioma. The patient also received radiotherapy (40Gy/15fr). Outcomes:No recurrence was observed during the 9-month follow-up. Lessons:This case highlights the potential for low-grade meningiomas to undergo malignant transformation, particularly in the presence of irregular lobulation, peritumoral brain edema, and heterogeneous enhancement on contrast-enhanced scans. Total excision (Simpson grade I) is the preferred treatment option, and long-term imaging follow-up is recommended.

Acute intraoperative cerebral herniation is catastrophic in craniotomy and seriously affects the outcomes of surgery and the prognosis of the patient. Although the probability of its occurrence is low, it can lead to severe disability and high mortality. We describe a rare case of intraoperative cerebral herniation that occurred in a syphilis-positive patient. The patient was diagnosed with both glioma and syphilis. When the glioma was completely removed under the surgical microscope, acute cerebral herniation occurred. An urgent intervention in cerebral herniation identified a collection of colorless, transparent, and protein-rich gelatinous substances rather than a hematoma, which is a more commonly reported cause of intraoperative cerebral herniation in the literature. We have found no previous descriptions of such cerebral herniation during craniotomy in a patient with syphilis and glioma. We suspected that the occurrence of intraoperative cerebral hernia might be related to the patient's infection with syphilis. We considered the likelihood of an intraoperative cerebral herniation to be elevated when a patient had a disease similar to syphilis that could cause increased vascular permeability.

BACKGROUND:Mounting evidence suggests that there is a complex regulatory relationship between long non-coding RNAs (lncRNAs) and the glycolytic process during glioma development. This study aimed to investigate the prognostic role of glycolysis-related lncRNAs in glioma and their impact on the tumor microenvironment.METHODS:This study utilized glioma transcriptome data from public databases to construct, evaluate, and validate a prognostic signature based on differentially expressed (DE)-glycolysis-associated lncRNAs through consensus clustering, DE-lncRNA analysis, Cox regression analysis, and receiver operating characteristic (ROC) curves. The clusterProfiler package was applied to reveal the potential functions of the risk score-related differentially expressed genes (DEGs). ESTIMATE and Gene Set Enrichment Analysis (GSEA) were utilized to evaluate the relationship between prognostic signature and the immune landscape of gliomas. Furthermore, the sensitivity of patients to immune checkpoint inhibitor (ICI) treatment based on the prognostic feature was predicted with the assistance of the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm. Finally, qRT-PCR was used to verify the difference in the expression of the lncRNAs in glioma cells and normal cell.RESULTS:By consensus clustering based on glycolytic gene expression profiles, glioma patients were divided into two clusters with significantly different overall survival (OS), from which 2 DE-lncRNAs, AL390755.1 and FLJ16779, were obtained. Subsequently, Cox regression analysis demonstrated that all of these lncRNAs were associated with OS in glioma patients and constructed a prognostic signature with a robust prognostic predictive efficacy. Functional enrichment analysis revealed that DEGs associated with risk scores were involved in immune responses, neurons, neurotransmitters, synapses and other terms. Immune landscape analysis suggested an extreme enrichment of immune cells in the high-risk group. Moreover, patients in the low-risk group were likely to benefit more from ICI treatment. qRT-PCR results showed that the expression of AL390755.1 and FLJ16779 was significantly different in glioma and normal cells.CONCLUSION:We constructed a novel prognostic signature for glioma patients based on glycolysis-related lncRNAs. Besides, this project had provided a theoretical basis for the exploration of new ICI therapeutic targets for glioma patients.

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The insulin-like growth factor-binding protein (IGFBP) family is involved in tumorigenesis and the development of multiple cancers. However, little is known about the prognostic value and regulatory mechanisms of IGFBPs in GBM. Oncomine, Gene Expression Profiling Interactive Analysis, PrognoScan, cBioPortal, LinkedOmics, TIMER, and TISIDB were used to analyze the differential expression, prognostic value, genetic alteration, biological function, and immune cell infiltration of IGFBPs in GBM. We observed that IGFBP1, IGFBP2, IGFBP3, IGFBP4, and IGFBP5 mRNA expression was significantly upregulated in patients with GBM, whereas IGFBP6 was downregulated; this difference in mRNA expression was statistically insignificant. Subsequent investigations showed that IGFBP4 and IGFBP6 mRNA levels were significantly associated with overall survival in patients with GBM. Functional Gene Ontology Annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that genes coexpressed with IGFBP4 and IGFBP6 were mainly enriched in immune-related pathways. These results were validated using the TIMER and TSMIDB databases. This study demonstrated that the IGFBP family has prognostic value in patients with GBM. IGFBP4 and IGFBP6 are two members of the IGFBP family that had the highest prognostic value; thus, they have the potential to serve as survival predictors and immunotherapeutic targets in GBM.

该文采用UHPLC-MS/MS建立一种同时测定大鼠三叉神经节中4种神经递质的方法。SD大鼠三叉神经节组织匀浆后，加乙腈沉淀蛋白，制备成供试品溶液；以Discovery HS F5-3(2.1 mm×150 mm，3.0 μm）为色谱柱，0.1%甲酸溶液（A相）和0.1%甲酸-40%乙腈溶液（B相）为流动相，梯度洗脱进行分离；然后在+ESI和MRM模式下检测，以Glycine-N15为内标。结果表明：4种氨基酸的线性关系良好（r2≥0.999），检测限和定量限分别为0.14~1.23 ng/mL和0.47~4.11 ng/mL；在浓度范围内，进样精密度、日内和日间精密度良好，RSD分别在0.90%~5.17%，3.01%~7.19%，4.64%~14.49%；加样回收率为94.8%~108%。大鼠三叉神经节炎症模型在0，1，3，5，7 d 4种神经递质的含量均发生不同程度的变化，其中天门冬氨酸（Asp）在炎症期没有明显的变化（P>0.05），而其余3种递质变化显著（P<0.05），且谷氨酸(Glu)最明显，体外实验也证实 Glu 在炎症条件下含量增加。所建方法可高效同时分离检测三叉神经中4种氨基酸的含量，有较好的使用价值。

Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome. Although the translation of circRNAs was reported, additional coding circRNAs and the functions of their translated products remain elusive. Here, we demonstrate that an endogenous circRNA generated from a long noncoding RNA encodes regulatory peptides. Through ribosome nascent-chain complex-bound RNA sequencing (RNC-seq), we discover several peptides potentially encoded by circRNAs. We identify an 87-amino-acid peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that suppresses glioblastoma cell proliferation in vitro and in vivo. This peptide directly interacts with polymerase associated factor complex (PAF1c) and inhibits the transcriptional elongation of multiple oncogenes. The expression of this peptide and its corresponding circRNA are decreased in glioblastoma compared with the levels in normal tissues. Our results establish the existence of peptides encoded by circRNAs and demonstrate their potential functions in glioblastoma tumorigenesis.

OBJECTIVE To evaluate the value of intraoperative magnetic resonance imaging (iMRI) combined with neuronavigation for the resection of insular gliomas.
 Methods: From August 2014 to October 2017 in the First Hospital Affiliated to Sun Yat-sen University, clinical data of 41 patients with insular glioma, who underwent the surgery assisted with 3.0T iMRI and neuronavigation, were analyzed retrospectively, and the resection extent, complications and prognosis were evaluated.
 Results: Subtotal tumor resection was achieved in 21 patients and partial resection was done in 20 after iMRI scanning. After further resection, total tumor resection was achieved in 16 patients, subtotal resection in 18 and partial resection in 7. There was a statistical significant difference in tumor resection between pre-iMRI and post-iMRI according to the Fisher test (P<0.05). In the follow-up from 3 months to 3 years, the symptoms of the 41 patients had improved.
 Conclusion: iMRI corrected the shift of brain. Neuronavigation can accurately and timely assess the degree of resecting tumor. The combination of neuronavigation with surgery can maximally and safely resect insular glioma.

AIM:Combination treatment consisting of surgery and pre-or post-operative corticosteroids for chronic subdural hematoma (CSH) tend to have better outcomes than surgery only. However, there are many complications after long-term use of corticosteroids. In this study, we evaluated the clinical outcomes of local application of corticosteroids combined with surgery for CSH.MATERIAL AND METHODS:We retrospectively analysed the data of the patients undergoing surgery and local application of Methylprednisolone Sodium Succinate for Injection (MPSS) into the hematoma cavity. Neurological status was assessed by Markwalder's Grading Scale (MGS). Recurrence was defined as deteriorating neurological status with radiological evidence of reaccumulation.RESULTS:A total of 26 patients were enrolled in this study. During the follow-up period, all patients made excellent neurological recovery. 24 (92.3%) patients' MGS was grade 0 at 12 months after the surgery. There was no mortality or recurrence. 5 patients (19.2%) suffered postoperative complications, of which 2 developed some subdural air collection, 2 had a partial seizure attack and 1 developed an acute epidural hemorrhage.CONCLUSION:The results suggest that local application of MPSS combined with surgery is a safe and effective method in the management of CSH. It may reduce hematoma recurrence.

Department of Neurosurgery, The First People's Hospital of Neijiang, Neijiang Sichuan, China The authors have no funding or conflicts of interest to disclose.

Objective To define the anatomical characteristics of the insula and its relation with its surrounding structures that can lead to precisely design the microsurgical approaches of the insular region.Methods We analyzed the head data of 15 Chinese adult cadavers(30 hemispheres)fixed by 10% formalin.The relative anatomical landmarks of the insular region and the distance from the insula to its peripherally correlative structures were measured and described. Results The insula,being one of the paralimbic structures,constituted the invaginated portion of the cerebral cortex and formed the base of the sylvian fissure.The insula was covered and enclosed by the frontoorbitsl,frontoparietal and temporal opercula and the transmigrated part of the insula was the uncinate extreme capsule,the white matter region inferior to the insular cortex.The insula was adjacent to the external capsule,the claustrum,the internal capsule,the lenticular nucleus,the caudate nucleus and the thalamus.The insula separated the endbrain and the limbic structures like an inverted pyramid.Various unique anatomical features of the insula and the peripheral relations with the insula were determined by using the fiber dissection techniques.Conclusion A good understanding of the surgical anatomy,being extremely important for a neurosurgeon, can guide us to operate for such series of frequent and multiple diseases aS hypertensive intracerebral hemorrhage from the basal ganglia,the insular glioma and temporal lobe epilepsy in the neurosurgery.