Background Despite an increase in parathyroid hormone (PTH) has been reported to be associated with a higher risk of hypertension and type 2 diabetes (T2D), the comprehensive evaluation of the dose-response relationship between PTH and hypertension and T2D remains ambiguous. Therefore, a dose-response meta-analysis was performed to quantitatively investigate this association. Methods PubMed, Web of Science, and Embase were systematically searched up to May 2023. Random-effect models were used to estimate the summary odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were used to model the dose-response association. Results Ten articles (including 13 studies) were identified, with a total of 11,878 cases and 51,234 participants in the meta-analysis. Of these studies, eight (five cohort and three cross-sectional) studies investigated the association of PTH with hypertension; five (two cohort and three cross-sectional) studies assessed the association of PTH with T2D. The results showed a positive relationship between PTH and the risk of hypertension (OR,1.24, 95% CI: 1.16–1.33). We found a linear association between PTH and hypertension ( P non−linearity = 0.222). In the dose-response analysis, the risk of hypertension increased 5% for every 10 pg/ml increase in PTH (OR,1.05, 95% CI: 1.02–1.08). The pooled OR of T2D risk for a 10 pg/ml increase in PTH was 1.00 (95% CI: 0.98–1.02). Conclusions Elevated PTH is associated with an increased risk of hypertension. However, the evidence of the association between PTH and T2D is limited, and more well-designed studies need to be explored.

Objective:To study the reliability and validity of the Chinese Nanjing persistent vegetative state scale（CNPVSS）in assessing the state of consciousness of brain-damaged patients in different gender and age subgroups，so as to provide a point of scientific reference for the clinical application of the scale.Methods:The reliability of the CNPVSS was calculated by statistically analyzing the CNPVSS scores of 1 100 patients in different states of consciousness after brain injury. The validity of the scale was analyzed by applying it to four states of consciousness：coma，vegetative state / unresponsive awakening syndrome（VS/UWS），minimally conscious state（MCS），and conscious wakefulness. The male and female patients were further divided into four age subgroups，respectively：1–20 years old，21–40 years old，41–60 years old，and 61–80 years old. The reliability and validity of CNPVSS scale in the eight groups were then evaluated.Results:The reliability of CNPVSS was good，and the Cronbach’s alpha coefficient was 0.969；the internal consistency was good（ P<0.001），and the correlation between the score of each item and the total score was statistically significant（ P<0.001）；the total scores of different states of consciousness：coma［1（1，2）］，VS / UWS［2（2，3）］，MCS［7（6，9）］，and conscious wakefulness［19（16，20）］，with statistically significant difference（ P<0.001）. The reliability and validity of the scale in different gender and age subgroups come out well，and the results were basically consistent with the overall analysis. Conclusion:CNPVSS is a good instrument for assessing the state of consciousness，which can be used for quantitative analysis of consciousness states of brain-damaged patients under 80 of different gender.

Objective:To investigate the effects of minimally invasive aspiration and drainage combined with hyperbaric oxygen (HBO) therapy on inflammatory factors and cerebrovascular dynamic indicators in patients with hypertensive intracerebral hemorrhage.Methods:A total of 74 patients with hypertensive intracerebral hemorrhage treated in 454 Hospital and Nanjing Zijin Hospital from January 2019 to January 2021 were selected and randomly divided into treatment group ( n=37) given minimally invasive aspiration and drainage combined with HBO therapy and control group ( n=37) given minimally invasive aspiration and drainage only. The levels of serum inflammatory factors, cerebrovascular dynamic indicators, arterial blood gas (ABG) levels, and the neurologic function scores in the two groups before and after treatment were compared. Results:Before treatment, there was no significant difference between the two groups in the levels of serum inflammatory factors, cerebrovascular dynamic indicators, ABG levels, and the neurological function scores ( P>0.05); after 30 days of treatment, the levels of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-1(IL-1), and IL-8 in the treatment group were lower than those in the control group, the National Institute of Health Stroke Scale (NIHSS) scores, the values of peripheral resistance (PR) and dynamic resistance (DR) in the treatment group were lower than those in the control group, while the Mini-mental State Examination (MMSE) scores, the mean blood flow velocities (Vm), mean blood flow quantities (Qm), the arterial partial pressures of CO 2 (PaCO 2) and the arterial partial pressures of oxygen (PaO 2), and the blood pH values in the treatment group were higher than those in the control group ( P<0.05), and all the differences were statistically significant ( P<0.05). Conclusion:Minimally invasive aspiration and drainage combined with HBO therapy in the treatment of hypertensive intracerebral hemorrhage can effectively reduce the patients’ inflammatory response and promote the recovery of cerebral vascular dynamics and nerve function.