Spiral resonator corneal contact lenses for continuous intraocular pressure (IOP) are promising devices for the diagnosis of glaucoma. Here, we design a spiral resonator corneal contact lens with high sensitivity and simplify the fabrication process. A method for manufacturing 3D spiral microfluidic channels in corneal contact lenses is proposed. The use of liquid metal improves the sensitivity of spiral resonators and does not affect the deformation of the lens. The performance of the device is evaluated using an artificial silicone eye. The sensitivity of the sensor reached 0.2557 $\text{MHz}/\upmu\mathrm{L}$ and the results proved its good stability and repeatability. The results show its great potential for clinical application.

A flexible, lightweight self-powered pressure sensor with microstructured stretchable electrode and piezoelectric active layer is developed with potential for wide range of applications such as wearable electronics. The bottom electrode made of MWCNT/PDMS composite has good elasticity and can effectively concentrate the strain when subjected to a pressure. Piezoelectric polymer poly (vinylidene fluoride-co-trifluoroethylene) (PVDF-TrFE) and conductive polymer-based top electrode are subsequently coated onto the microstructured electrode. We study the response of the sensor in terms of various bottom electrode configuration and thickness of piezoelectric sensing layer. The enhanced performance of the sensor is attributed to the stress concentration effect of the electrode with microstructures and the anisotropic crystal properties. This self-powered sensor has potential to monitor the sudden impact that subjected to human body.

PEDOT:PSS conductive polymers have received tremendous attention over the last two decades owing to their high conductivity, ease of processing, and biocompatibility. As a flexible versatile material, PEDOT:PSS can be developed into various forms and has had a significant impact on emerging sensing applications. This review covers the development of PEDOT:PSS from material to physical sensors. We focus on the morphology of PEDOT:PSS in the forms of aqueous dispersions, solid films, and hydrogels. Manufacturing processes are summarized, including coating, printing, and lithography, and there is particular emphasis on nanoimprinting lithography that enables the production of PEDOT:PSS nanowires with superior sensing performance. Applications to various physical sensors, for humidity, temperature, pressure, and strain, are demonstrated. Finally, we discuss the challenges and propose new directions for the development of PEDOT:PSS.

智能生物传感器是全球柔性电子科学的前沿和研究热点,以集成硅基微电路芯片为生物传感器的研发核心,因在医疗和临床环境中可以实现稳定而持续的数据采集、处理和无线传输,从而参与多种器官和组织疾病的监测、诊断、治疗以及随访等而具有特定优势及潜在应用价值.本文针对眼科领域的相关研究、设计用于眼科疾病的智能生物传感器的种类,包括构成材料、结构布局、组装方法,电源和数据处理等诸方面予以综述,尤其对智能生物传感器在眼科疾病监测、诊断及治疗之中的潜在应用前景进行综述.

Microfluidic contact lenses (MCLs) for continuous intraocular pressure (IOP) monitoring are promising devices for the diagnosis and management of glaucoma. Here, we present an ultra-sensitive and cost-effective MCL for IOP monitoring. A folding method that allows 2D-to-3D transformation of a planar microchannel is introduced. An ultra-sensitive serpentine microchannel of notched-ring configuration is designed in coordination with the folding method. The optimization of the microchannel geometry is performed through numerical simulations and experiments. The performance of the device is evaluated using a hemispherical silicone model eye. The sensitivity of the MCL reaches up to 0.825°/μl, which clearly exceeds the existing MCLs. Moreover, stair-case and cyclical tests are performed to confirm the device's recoverability and repeatability. These results prove that the proposed MCL is a suitable selection for intraocular pressure monitoring.

器官芯片是生命科学领域的新兴前沿科学,它利用微流控技术构建以模拟人体组织和器官功能为目标的集成微系统,可以为药物筛选和疫苗的有效性、安全性评估以及其他多种生物医学研究提供更接近人体真实生理和病理条件的低成本研究模型.器官芯片不仅可以模拟人体目标器官的三维微环境,而且具备样品消耗少、检测速度快、操作简便、多功能集成、精度高、自动化和便携等优点,拥有简化采集标本及诊断流程,助力提高医疗效果的巨大潜力.目前,微流控器官芯片技术正以惊人的速度快速发展,心脏、肾脏、肝脏、肺脏以及血管等全身多个器官组织相关芯片产品陆续研发成功.眼科领域的器官芯片研究目前集中在角膜相关疾病、视网膜及脉络膜疾病等.本文就器官芯片在眼科领域中的研究进展进行综述.

Robotic hands with tactile perception can perform more advanced and safer operations, such as material recognition. Nanowires with high sensitivity, fast response, and low power consumption are suitable for multifunctional flexible tactile sensors to provide the tactile perception of robotic hands. In this work, we designed a multifunctional soft robotic finger with a built-in nanoscale temperature-pressure tactile sensor for material recognition. The flexible multifunctional tactile sensor integrates a nanowire-based temperature sensor and a conductive sponge pressure sensor to measure the temperature change rate and contact pressure simultaneously. The developed nanoscale temperature and conductive sponge pressure sensor can reach a high sensitivity of 1.196%/°C and 13.29%/kPa, respectively. With this multifunctional tactile sensor, the soft finger can quickly recognize four metals within three contact pressure ranges and 13 materials within a high contact pressure range. By combining tactile information and artificial neural networks, the soft finger can recognize the materials precisely with a high recognition accuracy of 92.7 and 95.9%, respectively. This work proves the application potential of the multifunctional soft robot finger in material recognition.