宫颈癌是全世界常见的女性恶性肿瘤.由于肿瘤转移或复发,特别是对于那些晚期肿瘤患者,宫颈癌的总体预后仍然很差.肿瘤转移约占所有与癌症相关死亡的90％.因此,鉴定转移的原因和潜在标志物对于促进早期诊断,预测预后和制定新的宫颈癌治疗策略具有重要意义.在宫颈癌的发展和恶性进展期间,许多microRNA(miRNA)已被证明能显著失调.越来越多的证据表明,miRNA可以有效调节上皮间质转化(EMT)的过程,miRNA包含控制EMT信号通路和直接靶向EMT转录因子进而调节癌细胞的侵袭和转移性,本文将简要阐明miRNA调控EMT对宫颈癌侵袭转移性的影响.

There are many fuctions with the representative autophagy associated protein p62, such as cell signal transduction, cell proliferation, apoptosis, inflammation, tumorigenesis and oxidative stress. p62 over express will lead to autophagy disorder by controlling keap1-Nrf2mTORC1, NF-κB signaling pathways, thus promoting the development of the tumor. The overexpression of p62 in tissues can lead to the occurrence of the gynecological malignant tumors, such as ceicival cancer, ovarian carcinoma and Endometrial carcinoma. And the level of p62 is correlated with the tumor progression, the tumor grade and the survival rates of patients. p62 and its upstream and downstream molecules are expected to be the markers and therapeutic targets for predicting the clinical outcome of the gynecological malignant cancer patients.

自噬是通过溶酶体依赖性途径降解和再循环细胞溶质组分或细胞器的保守分解代谢过程,其负责长寿命蛋白质、蛋白质聚集体以及受损细胞器的降解以维持细胞稳态.因此,自噬的异常与许多疾病相关,包括阿尔茨海默病,帕金森病和癌症.根据目前的观点,自噬似乎在癌症形成的早期阶段充当肿瘤抑制剂,但在后期阶段,自噬可以促进肿瘤的生长、扩散.microRNA(miRNA)是内源性非编码小RNA,其通过沉默mRNA靶标来调节基因表达.在体细胞发育、造血、免疫、细胞增殖和死亡以及自噬过程中,miRNA失调表现出巨大的调节潜力.近年来大量的研究表明miRNA可通过调节靶向基因表达来调节细胞自噬进而有助于癌症形成,以及癌症的进展.在本综述中,将简要阐明miRNA对自噬的调控在癌症中的作用.