目的:探讨正念减压疗法在冠状动脉介入治疗术（PCI）术后冠心病病人中的应用效果。方法:选取2018年6月—2019年1月在我院接受住院治疗的61例冠心病支架置入病人为研究对象，将病人随机分为干预组（30例）和对照组（31例），对照组接受常规健康教育、治疗护理等，干预组在对照组基础上实施正念减压疗法。于干预前后采用医院焦虑抑郁量表（HADS）、压力知觉量表（PSS）、五因素正念量表简明版（FFMQ-SF）对病人进行评价。结果:干预后，干预组HADS总分及其焦虑亚量表得分、抑郁亚量表得分以及PSS得分均低于干预前及同期对照组，焦虑、抑郁病人少于干预前，干预组FFMQ-SF得分高于干预前及同期对照组，差异均有统计学意义（P＜0.05）。结论:在冠心病PCI术后病人中实施正念减压疗法可降低病人焦虑、抑郁风险，改善病人压力，提高病人正念水平。

目的 分析诱导型一氧化氮合酶(iNOS)基因多态性与病毒性心肌炎(VMC)易感性和心肌病变程度的关系.方法 选取2018年1月-2020年7月海南医学院第一附属医院收治的VMC患者65例为VMC组,并选取同期体检健康者48名为对照组.采用聚合酶链式反应-限制性内切酶片段长度多态性(PCR-RFLP)技术,检测iNOS基因rs2779248和rs1137933位点的基因型分布情况,酶联免疫吸附法(ELISA)检测血清iNOS水平,比较两组iNOS基因多态性及不同基因型血清iNOS水平.结果 VMC组iNOS基因rs2779248位点T等位基因频率高于对照组(P＜0.05),rs1137933位点TT基因型和T等位基因频率均高于对照组(P＜0.05);不同基因型血清iNOS水平比较有统计学意义(P＜0.05),且VMC组患者各基因型血清iNOS水平均高于对照组(P＜0.05);急性期和重症VMC患者iNOS基因rs2779248和rs1137933位点TT基因型和T等位基因频率均高于恢复期和轻症患者(P＜0.05).结论 iNOS基因rs2779248位点和rs1137933位点的多态性可能与VMC患者易感性及心肌病变程度有关.

OBJECTIVE To investigate the distribution and drug resistance of pathogens isolated from chronic heart failure patients complicated with pulmonary infection so as to provide guidance for reasonable clinical use of antibi‐otics .METHODS A total of 72 chronic heart failure patients complicated with pulmonary infection who were trea‐ted in the hospital from May 2014 to May 2015 were enrolled in the study .The distribution of the pathogens cau‐sing the infection was analyzed ,and the result of drug susceptibility testing was observed .RESULTS Totally 91 strains of pathogens were isolated from the 72 patients ,including 55 (60 .4% ) strains of gram‐negative bacteria , 34 (37 .4% ) strains of gram‐positive bacteria ,and 2 (2 .2% ) strains of fungi .The gram‐negative bacteria were highly resistant to aminoglycosides ,quinolones ,and third generation cephalosporins ;the drug resistance rates of Klebsiella pneumoniae ,Acinetobacter baumannii ,and Pseudomonas aeruginosa to streptomycin were as high as 100 .0% .The drug resistance rates of A .baumannii and P .aeruginosa to ciprofloxacin were 100 .0% .The drug resistance rates of Escherichia coli ,A .baumannii ,and P .aeruginosa to ceftriaxone were as high as 100 .0% ;however ,the strains remained highly susceptible to meropenem ,imipenem ,amikacin ,and cefoperazone‐sulbac‐tam .The drug resistance rate of the E .coli to meropenem and imipenem was 3 .6% ;the drug resistance rate to amikacin and cefoperazone‐sulbactam was 7 .1% .The drug resistance rate of the K .pneumoniae to meropenem and imipenem was 13 .3% ;the drug resistance rates to amikacin and cefoperazone‐sulbactam were 26 .7% and 20 .0% ,respectively .The gram‐positive bacteria were generally resistant to penicillin and clindamycin ;the drug resistance rates of Enterococcus and Staphylococcus aureus to penicillin G were 80 .0% ,the drug resistance rates to clinda‐mycin were 100 .0% ,however ,the strains remained highly susceptible to vancomycin ,teicoplanin ,and rifampi‐cin .The drug resistance rates of the Enterococcus to vancomycin ,teicoplanin ,and rifampicin were 0 .5% ,1 .0% , and 30 .0% ,respectively ;the drug resistance rates of the S .aureus to vancomycin ,teicoplanin ,and rifampicin were 11 .1% ,11 .1% ,and 1 .1% ,respectively .CONCLUSION The gram‐negative bacteria are dominant among the pathogens isolated from the chronic heart failure patients complicated with pulmonary infection .Meropenem , imipenem ,amikacin ,and cefoperazone‐sulbactam remain susceptible to the strains ,which provides guidance for clinical use of antibiotics .