Objective:To explore the clinical significance of combine serum progesterone and inhibin A in prediction of outcomes of threatened abortion. Method:Clinical data of 156 cases of early monovular pregnancy(5-12 weeks) were divided into three groups:normal intrauterine pregnancy group,threatened abortion group and inevitable abortion group,each with 60 cases.Serum progesterone and inhibin A level were assayed with ELISA in all the cases. Result:The progesterone level of inevitable abortion was significantly lower than that of threatened abortion(P0.05).The serum inhibin A level of inevitable abortion was significantly higher than that of threatened abortion(P 0.05).The serum progesterone and inhibin A level assay was valuable in detecting inevitable abortion.Separate serum progesterone 14.3 ng/mL,The sensitivity,specificity and accuracy were 72.1%,78.6% and 78.1%.If combine with inhibin A 144.95pg/mL,the three rates would be 88.2%,84.2%,90.6%. Conclusion:Combine serum progesterone and inhibin A level assay is more valuable than single index in forecast the outcome of threatened abortion.

Objective To explore the role of COX-2 and VEGF in oncongensis and development of gestation-al trophoblastic disease,and evaluate prognosis of gestational trophoblastic tumor. Methods The expression of COX-2 and VEGF in normal chorion of early gestation and in gestational trophoblastic disease were detected by immunohis-tochemistry. Results In gestational trophoblastic tumor group,the positive rate of COX-2 and VEGF were significantly highter than that of normal chorion of early gestation group and the hydatidiform mole group respectively ( P < 0.01). There were positive correlation between COX-2 and VEGF in gestational trophoblastic tumor ( r = 0.795, P < 0.01). Conclusion The collaborative and over expression of COX-2 and VEGF were probably associated with the malignant change of trophoblastic cell,which suggest the worse prognosis of the gestational trophoblastic disease.

目的 探讨肺功能训练对开胸手术患者中的影响.方法 选择开胸手术患者80例,采用随机分组,单号40例为训练组,双号40例为对照组,训练组术前专门指导呼吸操及训练咳嗽,非训练组未行特殊训练.对两组患者在手术后能否行有效的咳嗽及肺部并发症进行资料收集统计.结果 与对照组比较训练组患者术后能进行有效咳嗽率高,肺部并发症发生率减少.结论 对开胸手术患者术前进行肺功能训练,可以改善患者的肺功能,减少肺部并发症的发生,降低手术的风险,减轻患者负担。

目的 探讨新生儿窒息后早期血浆血管性假血友病因子(VWF)的水平变化规律及其临床意义.方法 检测45例不同程度窒息新生儿的血浆VWF水平,同时测定血小板,并与30例正常新生儿比较.结果 新生儿窒息,其血浆VWF水平有不同程度的增高,轻度窒息组和重度窒息组血浆VWF水平明显高于对照组,差异有统计学意义(P<0.01);且重度窒息组血浆VWF水平变化明显高于轻度窒息组(P<0.05).正常对照组与轻度窒息组比较,血小板变化不明显(P>0.05),重度窒息组血小板稍下降.结论 新生儿窒息后早期存在内皮细胞损伤及凝血功能异常,血浆VWF水平异常程度与窒息程度有关,测定血浆VWF水平是反映血液高凝状态,估计疾病严重程度的一个指标,同时对临床选用抗凝药物治疗及疗效观察、预后判断,均有一定的指导意义.