The purpose of the study is to investigate the effect of organic selenium and low doses of zinc on nickel intoxication. Selenium and zinc were administered once daily at a dose of 4 and 1 mg/ kg. Nickel chloride (5 mg/kg) was administered intragastrically using a probe, daily for one month. At the end of the experiment time (30 days), the main parameters of systemic hemodynamics were determined. The arterial blood pressure from the femoral artery was measured and the mean (MAP) was calculated. Cardiac output was determined by thermal dilution, heart rate (HR) was recorded; cardiac index, shock index and specific peripheral vascular resistance were calculated using special formulas. Our findings showed that nickel leads to significant disruptions in hemodynamics and heart function of rats, manifested in an increase in MAP, a change in heart rate, a decrease in systolic output. The introduction of selenium or small doses of zinc in rats exposed to nickel, produced a noticeable decrease in the cardiotoxic effects of this metal. There was also a decrease in the hypertensive effect of the metal. Thus, it has been established that antioxidants selenium and zinc can effectively reduce nickel toxicity.

Purpose: To examine the possibility of using vitamin E for the correction of free radical oxidation disorders and haemodynamic effects of potassium bichromate. Methods: Experiments were performed in 90 male Wistar rats; the study included 9 experimental groups. Vitamin E and sunflower oil (control) were injected daily intragastrically through an atraumatic tube into the stomach. At the end of the experimental period (30 days and 60 days), the main parameters of systemic hemodynamics and values of lipid peroxidation were measured. Differences between groups were analyzed using Student’s t-test. Results: The analysis of basic parameters of systemic haemodynamics showed that PO administration of potassium bichromate promoted an increase in mean arterial pressure due to the increase in normalized peripheral vascular resistance (systemic vascular resistance, SVR). At the same time there was a decrease in the stroke volume index. The haemodynamic effects of chromium were more pronounced with prolonged administration. Parameters of systemic hemodynamics in combined administration of potassium bichromate and sunflower oil changed similarly to the effects of combined administration of the metal and vitamin E, but changes were less pronounced. A decrease in SVR and the restoration of the stroke volume index were observed. The isolated administration of the metal for thirty days resulted in an increase in lipid peroxidation (LPO) accompanied by a stimulation of catalase and superoxide dismutase activity. During prolonged (2 months) isolated administration of potassium bichromate, a more pronounced increase in LPO was observed along with the depletion of the antioxidant system. The prevention of chromium intoxication using vitamin E during the first month of administration reduced lipoperoxidation phenomena accompanying increased antioxidant defense activity. These dynamics persisted after two months of the combination of vitamin E and potassium bichromate. Conclusions: The intragastric administration of potassium bichromate for 30 and 60 days resulted in arterial hypertension in a rat model. The administration of toxic doses of potassium bichromate to laboratory animals may lead to the activation of lipid peroxidation. The administration of vitamin E may attenuate the haemodynamic effects of chromium intoxication and the activation of lipid peroxidation.

The administration of the heavy metal cobalt to animals leads to an increase in mean arterial pressure, despite the decline in stroke and cardiac indices. Toxic effect of cobalt is manifested in hypertension hypotonic type. Just noted that the route of administration of the metal does not affect the parameters of systemic hemodynamics.