目的 了解苏州市相城区某幼儿园1起由札如病毒引起的聚集性疫情.方法 运用描述性流行病学方法,分析聚集性疫情流行病学特征.采集病例肛拭子、呕吐物和粪便以及环境样本,进行可疑病原体PCR核酸和致病菌检测.结果 2019年9月1-6日,通过病例搜索共发现病例16例,确诊病例8例,临床诊断病例8例.临床症状以呕吐为主(16例,占100.00％).发病至痊愈间隔平均为2.50d,就诊组为2.12d,未就诊组为2.88 d,差异无统计学意义(t=-1.33,P=0.21).发病时间主要集中在9月5日16:00-9月6日10:00,呈现点源传播方式,病例全部分布在小三班,罹患率为40.00％(16/40).病例样本核酸检测诺如病毒、轮状病毒、星状病毒均为阴性,札如病毒阳性9份,阳性率50.00％,确诊病例8例,其1例肛拭子和粪便均为札如病毒阳性.环境样本检测诺如病毒、沙门菌和志贺菌均为阴性.结论 本次疫情是一起札如病毒引起的胃肠炎聚集性疫情,教室内接触可能是主要传播途径.

目的 调查2020年苏州市相城区某社区一起由诺如病毒引起的聚集性感染事件,查找病因和传播危险因素,为新型冠状病毒疫情期间社区胃肠道传染病防控提供科学依据.方法 制订病例定义并进行流行病学调查,运用描述性和分析性统计方法分析聚集性感染事件流行病学特征和危险因素,采集病例咽、肛拭子和井水标本,进行可疑病原体PCR核酸和致病菌检测.结果 本次感染事件共发现病例15人,其中患者≥10岁组罹患率为23.08％(6/26),<10岁组罹患率为81.82％(9/11),两组差异有统计学意义[Fisher's法(双侧)P=0.002].病例对照研究显示:门口玩耍暴露差异有统计学意义[Fisher's法(双侧)P=0.006,OR值=11.43,95％CI:1.94～67.26],是本次胃肠炎的暴露危险因素.结论 本次聚集性感染是由GⅠ型诺如病毒引起,传播途径是儿童一起玩耍,相互接触传染,发病后又引起家庭内部传播.

目的 了解苏州市吸毒人群艾滋病相关行为及HIV感染情况.方法 按《全国艾滋病哨点监测实施方案操作手册》,对苏州市公安局强制隔离戒毒所2011-2015年监测期内(4-6月)新人所吸毒人员进行问卷调查,并采静脉血进行HIV抗体检测.结果 2011-2015年共调查2 008名吸毒者,检出HIV阳性者23例,阳性率为1.15％,23例HIV阳性者中外省流入病例占91.30％.吸毒者艾滋病知识知晓率为69.62％,19.82％的吸毒者承认最近1年中有过商业性行为,最近1次安全套使用率为57.04％.注射吸毒者占10.36％,注射吸毒比例呈逐年下降趋势(P＜0.05);注射吸毒者中,最近1个月有注射吸毒的占54.33％,有共用注射针具行为的占39.90％,最近1个月共针行为的占24.78％.结论 苏州市吸毒人群中注射吸毒比例呈下降趋势,但艾滋病知识知晓率及商业性行为中安全套使用率较低,应进一步加强干预工作.

Objective To survey the infection rate of AIDS, syphilis and hepatitis C of male homosexuality in Suzhou from 2013 to 2014 and provide scientific and reliable basis for the prevention and control work. Methods The male homosexuali-ty aged from 20 to 50 in Suzhou in 2013 and 2014 were given HIV, TP and HCV antibody test, and the infection rate and distribution characteristics were known. Results The positive rates of HIV, TP and HCV antibody of MSM in 2013 were re-spectively 6.03%, 21.0% and 0.95% in 2013 and 6.96%, 14.9% and 0 in 2014, the infection rate of HIV in 2014 slightly increased compared with that in 2013, and the infection rates of TP and HCV in 2014 decreased compared with those in 2013, and there was no obvious difference in data between the two years by comparison, P>0.05. Conclusion The infection rate of AIDS and syphilis of MSM in Suzhou are in the high level, we should widely carry out health education and imple-ment intervention measures, improve the awareness degree of relevant diseases, improve the safety prevention awareness and reduce the unsafety behavior and reduce the infection rate of sex transmitted disease in male homosexuality.

Background: HCV transmission is closely associated with injection drug use (IDU), and co-circulation of multiple subtypes has been found among injection drug users (IDUs) in China. Objectives: To investigate HCV subtype characterizations among IDUs and general population (GP) in Suzhou, a city at the important "Hu-ning" transportation line.Study design: During January 2010 to May 2011, 123 HCV positive plasma from IDUs and 131 stored HCV positive sera from general individuals were collected in Suzhou. HCV C/E2 and NS5B fragments were amplified using a new multiple RT-nested PCR strategy and subsequent sequenced. Genotypes were characterized by phylogenetic analyses.Results: Eight HCV subtypes (1a, 1b, 2a, 3a, 3b, 6a, 6n, and 6u) were detected among Suzhou IDUs, and six subtypes (1b, 2a, 3a, 3b, 6a and 6n) among GP. HCV subtype distribution is distinct between IDUs and GP. Interestingly, we detected discrepancy of genotyping results between C/E2 and NS5B regions in one general individual, indicating the presence of HCV intersubtype recombinant in China. The recombinant belongs to a 3a/1b recombinant. We also detected dual infections in one general individual and two IDUs. They include dual infections between 1b and 3a, 3a and 6a, and two distinct lineages of 3b.Conclusions: Complex patterns of HCV epidemic among IDUs, as well as GP, in Suzhou, might imply a spread of HCV from IDUs to GP. The finding of one HCV 3a/1b intersubtype recombinant might represent the first report of HCV recombination in China. (C) 2012 Elsevier B. V. All rights reserved.

近年来,我国艾滋病进入快速增长期,其中吸毒人员已成为HIV感染的高危人群.为及时掌握苏州市吸毒人群中艾滋病感染情况,为预防和控制艾滋病提供科学信息,根据江苏省疾控中心要求于2005年～2006年对苏州市戒毒所中所有新入所的吸毒人员进行了监测,结果报告如下.