Objective: To investigate the relationship between neutrophil/lymphocyte ratio(NLR), platelet/lymphocyte ratio(PLR), triglyceride-glucose(Ty G) index and renal function, insulin resistance(IR) and carotid atherosclerosis(CAS) in patients with type2 diabetic kidney disease(T2DKD). Methods: 90 patients with T2DKD who were admitted to our hospital from February 2018 to February 2022 were selected as the T2DKD group, and they were divided into CAS subgroup(n=51) and non-CAS subgroup(n=39) according to the results of carotid ultrasound examination, and another 46 patients with pure type 2 diabetes mellitus(T2DM) were selected as the T2DM group and 42 healthy individuals on physical examination were selected as the control group. Clinical data of each group were collected, the estimated glomerular filtration rate(eGFR) was estimated, and the urinary albumin/creatinine ratio(UACR), homeostasis model assessment insulin resistance index(HOMA-IR), NLR, PLR and Ty G index were calculated. Spearman correlation coefficient was used to analyze the correlation between NLR, PLR, Ty G index and renal function index and HOMA-IR in patients with T2DKD. Univariate and multivariate Logistic regression was used to analyze the influencing factors of CAS in patients with T2DKD. Results: NLR,PLR, Ty G index, UACR and HOMA-IR in the control group, T2DM group and T2DKD group were increased successively, while eGFR was decreased successively(P<0.05). Spearman correlation coefficient showed that NLR, PLR and Ty G index in patients with T2DKD were positively correlated with UACR and HOMA-IR, and negatively correlated with eGFR(P<0.05). Multivariate Logistic regression analysis showed that the increased age and the elevated HOMA-IR, UACR, NLR, PLR and Ty G index were independent risk factors for CAS in patients with T2DKD, and the elevated eGFR was independent protective factor(P<0.05). Conclusion: Elevated NLR, PLR and Ty G index in patients with T2DKD are closely associated with decreased renal function, IR and CAS, and which may be an index for assessing the risk of CAS in patients with T2DKD.
目的:提高对新型冠状病毒肺炎的认识和鉴别.方法:选取2020年2月至2020年3月确诊的170例新型冠状病毒肺炎患者作为研究对象,分析其主要临床特征,并与10例肺炎链球菌肺炎、10例腺病毒肺炎患者的临床特点进行比较.结果:170例患者中有发热160例(94.1%)、干咳109例(64.1%)、咳痰47例(27.7%)、乏力130例(76.5%)、胸闷气短109例(64.1%)、咽痛67例(39.4%)、纳差100例(58.8%)、肌肉酸痛56例(32.9%).出现并发症包括呼吸衰竭44例(25.9%)、休克8例(4.7%)、心力衰竭17例(10%)、死亡4例.普通型患者胸部CT主要表现为两肺多发斑片状影及间质改变,以肺外带明显.重型和危重型患者胸部CT主要表现为双肺多发磨玻璃影、浸润影,范围大,可出现肺实变.肺炎链球菌肺炎与新型冠状病毒肺炎比较,白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)明显升高,敏感抗生素治疗有效;腺病毒肺炎与新型冠状肺炎比较,并发症发生率更高,且用丙种球蛋白和全身激素治疗的比例更高.结论:新型冠状病毒肺炎传染性强,危害大,临床表现缺乏特异性,需与肺炎链球菌肺炎、腺病毒肺炎鉴别,避免误诊误治.