目的:对“老十针”治疗肝气郁结型餐后不适综合征(PDS)患者的随机对照试验进行期中分析.方法:纳入60例肝气郁结型PDS受试者进行期中分析,按照1:1的比例将受试者随机分为针刺治疗组和非穴浅刺组.主要结局指标是整体疗效评价的有效率.结果:治疗4周后,针刺治疗组和非穴浅刺组的有效应答率分别是76.7％(23/30)和43.3％(13/30),针刺治疗组有效应答率显著高于非穴浅刺组(P=0.006).与非穴浅刺组比较,针刺治疗组消化不良症状指数较基线数值下降(5.37±3.85),优于非穴浅刺组(2.54±3.46)(P=0.006).结论:针刺“老十针”可改善PDS患者的消化不良症状,仍需继续完成大样本试验验证其研究结果.

Background The evidence for different frequencies of acupuncture treatment in postprandial distress syndrome (PDS) is insufficient. This study determined whether 3 sessions per week of acupuncture treatment are superior to 1 session per week for symptomatic outcomes in PDS. Methods This 16-week randomized clinical pilot trial was conducted in an outpatient setting in China. Patients with PDS were randomly assigned to receive 3 sessions per week of acupuncture (group H) or 1 session per week of acupuncture (group L) for 4 weeks. The primary outcome was the complete elimination of core symptoms at week 4. Secondary outcomes included overall treatment efficacy, dyspepsia symptoms, quality of life, anxiety, and depression. Key Results Sixty patients were randomized of whom 53 (88.3%) completed this trial. The complete elimination rate of core symptoms was 26.7% (95% CI 12.3%-45.9%) in group H and 10.0% (95% CI 2.1%-26.5%) in group L at week 4 (P = .095). There was a significant difference between H and group L at weeks 8, 12, and 16 (P = .038, .02, and .02). All secondary outcomes were better in group H at all time points. No serious adverse events occurred in either groups. Conclusions This trial showed that acupuncture, at 3 sessions per week, tended to improve symptoms and the quality of life among patients with PDS as compared to once a week. Acupuncture treatment for 4 weeks was feasible and safe. A larger sample, multicenter, randomized controlled trial of acupuncture for PDS appears to be justified in the future.

Objective: We aimed to explore the feasibility of evaluating the comparative effectiveness and safety of electroacupuncture (EA) relative to manual acupuncture (MA) for the treatment of knee osteoarthritis (KOA). Methods: A multicenter randomized controlled clinical trial was conducted in Beijing from September 2017 to January 2018. A total of 60 participants with KOA were randomly allocated to either EA ( n = 30) or MA ( n = 30) groups. Participants in the EA group were treated with EA at six to seven local traditional acupuncture points or ah shi points, and two to three distal points. Participants in the MA group had the same schedule as the EA group except that the electrical apparatus featured a working power indicator without actual current output, constituting a sham EA procedure, in order to blind participants. Both groups received 24 sessions over 8 weeks. The primary outcome was response rate, defined as a change of ⩾50% from baseline in the total scores of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) after 8 weeks. Secondary outcomes included pain, stiffness, function, quality of life, and acupuncture-related adverse events (AEs) at 4 and 8 weeks. Results: Of 60 participants randomized, 53 (88%) completed the study. Response rates were 43% for the EA group and 30% for the MA group by the intention-to-treat analysis. Although significant differences were observed in WOMAC pain, stiffness, and function scores within both groups, between-group differences at 8 weeks did not reach statistical significance (odds ratio = 1.75 (95% confidence interval = 0.593–5.162)). Rates of AEs were low and similarly distributed between groups. Conclusion: Both EA and MA interventions in KOA were feasible and appeared safe. Whether or not EA may have a stronger impact on pain and function requires further evaluation through larger, adequately powered, randomized controlled trials. Trial registration number: NCT03274713.

功能性消化不良是以餐后饱胀、早饱感、上腹痛等症状为主要症状，经检查排除引起此类症状的器质性疾病的一组临床综合征。临床上常用的评价指标包括7分整体症状量表、鲁汶餐后不适症状评分量表、胃肠道症状积分问卷、胃肠道症状等级评估量表、功能性消化不良生活质量量表、尼平消化不良指数、固体胃排空检查和液体营养餐负荷试验等。现就各个评价指标的主要内容和自身特点进行比较和分析，旨在为功能性消化不良疗效指标的选择提供依据。

BackgroundPostprandial distress syndrome (PDS) has a considerable impact on quality of life. Our previous pilot trial suggested that acupuncture might be a potential treatment option for PDS. We will conduct this large trial to determine the efficacy of acupuncture versus sham acupuncture for PDS.Methods/designA total of 280 eligible patients who meet the Rome IV criteria for PDS will be randomly allocated to either the acupuncture group or the sham acupuncture group. Each patient will receive 12 sessions over fourweeks. The primary outcomes will be the response rate of overall treatment effect (OTE) and the elimination rate of all three cardinal symptoms (postprandial fullness, upper abdominal bloating, and early satiation) at fourweeks after randomization. Secondary outcomes will include assessments of the severity of dyspepsia symptoms and disease-specific quality of life at weeks 4, 8, and 16 after randomization. All patients who receive randomization will be included in the intent-to-treat analysis.DiscussionThe finding of this trial will provide high-quality evidence on the efficacy of acupuncture for treatment of PDS. Results of this research will be published in peer-reviewed journals.Trial registrationISRCTN Registry, ISRCTN12511434. Registered on 31 March 2017.

OBJECTIVE:To observe the clinical effect of acupuncture at "experienced ten acupoints" for postprandial distress syndrome.METHODS:A total of 62 patients with postprandial distress syndrome were randomly divided into an observation group (31 cases, 5 cases dropping off) and a control group (31 cases, 6 cases dropping off ). Acupuncture was applied at Baihui (GV 20), Zhongwan (CV 12), Qihai (CV 6), Tianshu (ST 25), Neiguan (PC 6), Zusanli (ST 36), Gongsun (SP 4), Danzhong (CV 17) in the observation group. In the control group, 6 non-acupoint points were intervened with shallow puncture. The treatment was given 20 min each time, once every other day, 3 times a week for a total of 4 weeks in the two groups. Symptom index of dyspepsia (SID) and Nepean dyspepsia index (NDI) scores were compared before and after treatment, and the efficacy was evaluated in the two groups.RESULTS:The effective rate in the observation group was 76.9% (20/26), which was higher than 28.0% in the control group (7/25, P<0.01). After treatment, the SID and NDI scores in the two groups were lower than those before treatment (P<0.01, P<0.05), and the SID and NDI scores in the observation group were lower than those in the control group (P<0.01, P<0.05).CONCLUSION:Acupuncture at "experienced ten acupoints" can significantly reduce the symptoms of dyspepsia and improve the quality of life in patients with postprandial distress syndrome.

After publication of the original article [1], the authors have notified us that the Trial registration number NCT03274713 should be replaced by NCT03366363 in the Abstract section of the paper.

目的 总结和分析针刺治疗术后肠麻痹的选穴规律,以期为针刺治疗术后肠麻痹提供选穴依据.方法 计算机检索中国知网、维普数据库、万方数据库、中国生物医学文献数据库、PubMed英文数据库中自建库以来针刺治疗术后肠麻痹临床研究的文献,筛选符合要求的文献,分析针刺治疗术后肠麻痹的选穴规律.结果 在纳入的62篇文献中,共使用腧穴34个,其中最常用的腧穴包括足三里、天枢、上巨虚等;选穴分布于11条经脉,腧穴使用频次最多的经脉是足阳明胃经(147次),占总频次的52.13％;涉及特定穴10种,最常用的2类特定穴是下合穴和募穴.结论 针刺治疗术后肠麻痹临床选穴以循经取穴为主,腧穴类型以下合穴、募穴等特定穴为主.

Subjective cognitive decline(SCD),a clinical condition in the early stage of Alzheimer's disease,manifests as a continuous decrease in the individual's self-conscious cognitive function but with normal objective cognitive indicators. Research on SCD helps to identify individuals at high risk of senile dementia and explore the effective prevention and intervention strategies. This article reviews the recent research advances in SCD,with an attempt to provide evidence for early intervention in patients with SCD.

A computer-based online search of CNKI,VIP,Wanfang and CBMdisc databases of acupuncture and moxibustion in the treatment of knee osteoarthritis clinical research literature,systematically analyzed the related documents.It is found that the methods of acupuncture and moxibustion in the treatment of knee osteoarthritis is diverse,including manual acupuncture,electro-acupuncture,acupotomy,moxibustion,laser acupuncture,fire needle and more than 10 species.Manual acupuncture,electro-acupuncture,acupotomy and warming needle are most commonly used,especially comprehensive therapy.Compared with foreign studies,domestic research has a high clinical efficiency,but it is difficult to rule out the impact of research bias on the results of the evaluation of the lack of convincing high-quality research.In the future,we should strengthen the top design of clinical research,optimize the treatment plan of acupuncture and moxibustion,and establish the technical operation standard of different acupuncture and moxibustion therapy for knee osteoarthritis.