A discriminant method was proposed for modeling and quantifying the consistency of regulatory mechanisms in the cardiovascular system (CVS) of apparently healthy volunteers and those suffering from circulatory disorders associated with cervical spine osteochondrosis (OCS) and somatoform autonomic dysfunction (SAD). The congruence of the parameters of ECG intervalometry (DCI) and pulse wave duration (PWD) according to the volunteers’ photoplethysmograms (PPG) was established by calculating the disparity measure and deviations from the mean values using the coeffi cients of displacement, slope of the approximating straight line, as well as by comparing the reliability and correlation of the trend model with the initial data. We discovered gross violations of congruence in the work of efferent and afferent regulatory CVS mechanisms, mismatch and decrease in comparison with the norm of DCI and PWD, a signifi cant decrease in their approximation in the SAD volunteers. In volunteers with OCS, deviations in DCI and PWD from their mean values are much lower than in those with SAD, being inferior compared to healthy volunteers. Similar to SAD, these patients are inferior to healthy volunteers in terms of the disparity measure.
Настоящая работа посвящена изучению влияния стресса на динамику показателей согласованной работы сердца и сосудов. Добровольцы с разной исходной вариабельностью сердечного ритма и нервной регуляцией сердечной деятельности отличаются согласованностью сердца и сосудов. Группа с высокой исходной вариабельностью сердечного ритма и значительно меньшим влиянием парасимпатического отдела на сердечную деятельность характеризуется более высокой согласованностью работы сердца и сосудов. Группа с низкой вариабельностью сердечного ритма и большим вкладом парасимпатической системы в регуляцию сердечной деятельности характеризуется низкой исходной согласованностью работы сердца и сосудов. Было выявлено, что стресс оказывает тормозящее влияние на представителей группы с высокой вариабельностью сердечного ритма и мобилизующе действует на представителей группы с низкой вариабельностью сердечного ритма. This work is devoted to the study of the influence of stress on the dynamics of indicators of the coordinated work of the heart and blood vessels. Volunteers with different initial heart rate variability and neural regulation of cardiac activity differ in the consistency of the heart and blood vessels. The group with high initial heart rate variability and significantly less influence of the parasympathetic division on cardiac activity is characterized by a higher consistency of the heart and blood vessels. The group with low heart rate variability and a large contribution of the parasympathetic system to the regulation of cardiac activity is characterized by low initial coordination of the heart and blood vessels. It was found that stress has an inhibitory effect on the representatives of the group with high heart rate variability and mobilizes the representatives of the group with low heart rate variability.
This work is devoted to the development of a new simplified method for express diagnostics of cerebral blood supply disorders of a vertebrogenic and non-vertebral nature based on electrocardiogram and photoplethysmogram data. The research was conducted using the example of vertebral artery syndrome in osteochondrosis of the cervical spine and somatoform dysfunction of the autonomic nervous system, respectively. Several experimental studies into the dynamics of heart rate variability and differential indicators of the coordinated work of the heart and blood vessels were carried out according to the data of electrocardiography and photoplethysmography. Three experimental groups included healthy volunteers and volunteers with cerebral blood supply disorders connected with either the loss of plasticity and narrowing of brain blood vessels or their mechanical squeezing. According to the research results, statistically significant (with a significance level of less than 0.05) differences by a number of indicators were revealed between the experimental groups. A conventional discriminant analysis of the indicators of the coordinated work of the heart and blood vessels was carried out for all experimental groups in order to determine criteria for differentiating people with vertebrogenic disorders, non-vertebral disorders and healthy volunteers. It is concluded that three variables can be used for such differentiation, each of which describes the coordinated work of the heart and blood vessels in a specific way.
A discriminant method was proposed for modeling and quantifying the consistency of regulatory mechanisms in the cardiovascular system (CVS) of apparently healthy volunteers and those suffering from circulatory disorders associated with cervical spine osteochondrosis (OCS) and somatoform autonomic dysfunction (SAD). The congruence of the parameters of ECG intervalometry (DCI) and pulse wave duration (PWD) according to the volunteers’ photoplethysmograms (PPG) was established by calculating the disparity measure and deviations from the mean values using the coeffi cients of displacement, slope of the approximating straight line, as well as by comparing the reliability and correlation of the trend model with the initial data. We discovered gross violations of congruence in the work of efferent and afferent regulatory CVS mechanisms, mismatch and decrease in comparison with the norm of DCI and PWD, a signifi cant decrease in their approximation in the SAD volunteers. In volunteers with OCS, deviations in DCI and PWD from their mean values are much lower than in those with SAD, being inferior compared to healthy volunteers. Similar to SAD, these patients are inferior to healthy volunteers in terms of the disparity measure.
This article investigates consistency in the work of the heart and blood vessels in vascular diseases of a vertebrogenic and non-vertebrogenic nature, which are characterized by disorders of the cardiovascular system leading to an insuffi cient blood supply to the spinal cord and the brain. Vertebrogenic vascular pathologies were studied by the example of vertebral artery disorders in osteochondrosis of the cervical spine, while non-vertebrogenic pathologies were considered in the syndrome of somatoform dysfunction of the autonomic nervous system. It is shown that, compared to the norm, the degree of consistence in the work of the heart and blood vessels is lower in vertebrogenic and non-vertebrogenic vascular pathologies.
The calculation algorithm of variability and size of current flow during micropolarizing impact on the set structures of a brain relying on earlier developed mathematical model of spreading of current in case of transcranial micropolarization for the stereotaxis coordinates is offered. The offered algorithm and mathematical model are developed taking into account the physical characteristics and methodical features of application of a method of micropolarization determining its efficiency for optimization of a functional condition of a brain is normal also in case of pathology.
The results of comparative analysis of physiological processes dynamics, which associated with animal and human different functional states, discussed in this article. Indices alteration of respiratory and cardiac activity in rest and electrosleep after physical activity in human and laboratory animals had similar tendencies and had been characterized with pattern likeness during changings one state on another one. The similarity between human and animal have allowed consider laboratory animals as valid model for approbation of initiation and modulation of functional states of nervous system techniques, including the low-frequency rhythmical electrical stimulation.
The main method of support of high level human efficiency in extreme condition was using pharmacological psychostimulating agents in practice of emergency and disaster medicine. As a result of high level stress effect as known probability of superfluous stimulatory action had lead to nervous system hyperactivation. Possibilities of reduction nervous system hyperactivation after physical activity and mental stress by transcranial electrocerebral rhythmical stimulation methods on the background of the stimulant action or without it modeling in laboratory rabbits discussed in this article. We had been shown on basis of heart and respiratory activity indices effectiveness of diagnostics of inhibitory effect on physiological system by the low-frequency rhythmical electrical subcortical brain stimulation. Respiration rate was more sensible to changes of animal functional status then heart rate. Duration of electrocerebral stimulation should increase by 5 min minimally subject to nervous system hyperactivation as compared with normal condition.
The present message is devoted to search of physiological markers of a condition of an electric sleep. Transcranial electric sleep is artificially generated by using the electric current analogue of natural sleep. On healthy volunteers athletes it is shown that the condition of an electric sleep is followed by increase in values of indicators of respiratory and warm activity, more characteristic for a condition of a relaxation, than for a condition of a natural dream. Along with it introduction of a Paroxetine (a selective inhibitor of reuptake of serotonin (SIRS)) before training and procedure of an electric sleep promotes change of dynamics and improvement of indicators of course of physiological processes. Application of a Paroxetine in controlled research improves a sleep, promotes turning on of relaxation mechanisms of an electric sleep. The melatonin role as possible intermediary in processes of a relaxation is discussed.
The article describes modern methods of production stimulating electrodes, here is given its description and analysis. The method of production stimulating electrodes is shown here. This method is developed on the basis of laboratory RSC "Kurchatov Institute".
In the present article ways of initiation of functional conditions of the nervous system which classification is offered within three-dimensional vector model of functional states are considered. The description of these ways of initiation demands definition of steady functional states and possible transients between them. Such specification of elements of model allows to create the effective tools allowing not only to diagnose functional states, but also to modulate them by means of physical methods of impact on nervous system.
The classification of functional status suggested in terms of the three-dimentional vector model of human functional states was described in the article. We had compared this classification with others experimental data and as a result of their relative analysis it was revealed that typical combination of diagnostic markers correspond to every functional state.
