Clinical observation of the successful use of the interleukin 6 (IL6) inhibitor sarilumab in secondary renal amyloidosis in a patient with active seropositive rheumatoid arthritis, is presented. This complication was confirmed by biopsy of rectum. The presented clinical example demonstrates a fairly rapid, within five years from the onset of the disease, the development of secondary renal amyolidosis with the formation of a persistent nephrotic syndrome that is resistant to therapy with cyclophosphamide and rituximab. Prescription of the IL6 inhibitor tocilizumab contributed to a decrease in the clinical and laboratory activity of the underlying disease, a decrease in the severity of daily proteinuria, but did not allow to achieve the full effect. The use of another IL6 inhibitor – sarilumab, led to a complete regression of nephrotic syndrome with normalization of general urine analysis, biochemical blood tests – total protein, albumin, total cholesterol, against the background of stable clinical and laboratory remission of rheumatoid arthritis.

В общей структуре патологии почек мочекаменная болезнь занимает второе место по встречаемости после воспалительных заболеваний. Мочекаменная болезнь в клинике обычно проявляется симптомами, обусловленными нарушением пассажа мочи по мочевыводящим путям. Классическим проявлением мочекаменной болезни является почечная колика – внезапно возникший приступ сильных болей в поясничной области, обусловленный нарушением оттока мочи от почки. Достаточно редко мочекаменная болезнь проявляется расстройствами мочеиспускания, вплоть до острой задержки мочи, которые обусловлены миграцией конкремента в мочеиспускательный канал. В данной статье приведен клинический пример неклассического проявления мочекаменной болезни пациента, поступившего первично с жалобами на учащенное моче испускание, ощущение неполного опорожнения мочевого пузыря, эпизодами гематурии, что после дообследования привело к постановке неточного диагноза и выписке больного на амбулаторное лечение. Через 4 дня у пациента развилась клиника острой задержки мочи, сопровождающаяся болевым синдромом и лихорадкой. Выставлен диагноз: острый обтурационный пиелонефрит, мочекаменная болезнь, камень мембранозного отдела уретры, острая задержка мочи. На фоне цистостомического дренажа проводилось стандартное лечение пиелонефрита, в последующем выполнена оптическая контактная литотрипсия камня уретры. Таким образом, важно тщательно проводить дифференциальный диагноз у больных с симптомами нижних мочевых путей, помнить об их неспецифическом характере и о редких случаях, которые в том числе могут быть обусловлены миграцией конкремента в мочеиспускательный канал. Длительное нарушение оттока мочи по мочевыводящим путям может служить причиной развития воспалительного процесса в почках, необратимой потери их функциональной способности и даже гибели пациента. По этой причине важно тщательно проводить дифференциальный диагноз у больных с симптомами нижних мочевых путей, помнить об их неспецифическом характере и редких случаях, которые в том числе могут быть обусловлены миграцией конкремента в мочеиспускательный канал. In the general structure of kidney pathology, urolithiasis is the second most common after inflammatory diseases. Urolithiasis in the clinic is usually manifested by symptoms caused by a violation of the passage of urine through the urinary tract. The classic manifestation of urolithiasis is renal colic – a sudden attack of severe pain in the lumbar region, caused by impaired outflow of urine from the kidney. Rarely enough, urolithiasis manifests itself as urinary disorders, up to acute urinary retention, which are caused by the migration of calculus into the urethra. This article provides a clinical example of a nonclassical manifestation of urolithiasis in a patient who was admitted primarily with complaints of frequent urination, a feeling of incomplete emptying of the bladder, episodes of hematuria, which, after further examination, led to an inaccurate diagnosis and discharge of the patient for outpatient treatment. After 4 days, the patient developed a clinical picture of acute urinary retention, accompanied by pain and fever. Diagnosed with acute obstructive pyelonephritis, urolithiasis, stone of the membranous urethra, acute urinary retention. On the background of cystostomy drainage, the standard treatment of pyelonephritis was carried out, followed by optical contact lithotripsy of the urethral stone. Thus, it is important to carefully carry out a differential diagnosis in patients with symptoms of the lower urinary tract, to remember their nonspecific nature and about rare cases, which, among other things, may be caused by the migration of calculus into the urethra. Prolonged disturbance of the outflow of urine through the urinary tract can cause the development of an inflammatory process in the kidneys, irreversible loss of their functional ability and even death of the patient. For this reason, it is important to carefully carry out a differential diagnosis in patients with symptoms of the lower urinary tract, to remember their nonspecific nature and rare cases, which, among other things, may be caused by the migration of calculus into the urethra.

Полимиозит (ПМ) и дерматомиозит (ДМ) — аутоиммунные заболевания скелетной мускулатуры неизвестной этиологии, которые относятся к системным заболеваниям соединительной ткани и объединяются общим термином «идиопатические воспалительные миопатии». Наиболее тяжелым подтипом полимиозита и дерматомиозита (ПМ/ДМ) является антисинтетазный синдром (АСС), ассоциированный с наличием специфических иммунологических маркеров в сыворотке крови – антисинтетазных антител. АСС имеет клинические особенности, отличающие его от группы ПМ/ДМ в целом. Интерстициальное заболевание легких – наиболее распространенное экстрамускулярное поражение при ПМ/ДМ является ключевым прогностическим фактором течения заболевания, а также определяет терапевтическую тактику и прогноз. Трудности своевременной диагностики ДМ с АСС зачастую связаны с тем, что заболевание может начинаться с легочной симптоматики при отсутствии явных признаков миопатии. Представлен клинический случай поздней диагностики данного заболевания. Polymyositis (PM) and dermatomyositis (DM) are autoimmune diseases of skeletal muscles of unknown etiology, which belong to systemic diseases of the connective tissue and are collectively called «idiopathic inflammatory myopathies». The most severe subtype of polymyositis and dermatomyositis (PM/DM) is antisynthetase syndrome (ACC), associated with the presence of specific immunological markers in the blood serum – antisynthetase antibodies. ACC has clinical features that distinguish it from the PM/DM group as a whole. Interstitial lung disease, the most common extramuscular lesion in PM/DM, is a klyuchevoy prognostic factor in the course of the disease, as well as determining therapeutic tactics and prognosis. Difficulties in the timely diagnosis of DM with ACC are often associated with the fact that the disease can begin with pulmonary symptoms in the absence of obvious signs of myopathy. A clinical case of late diagnosis of this disease is presented.

Clinical case of a successful kidney transplantation in a patient with secondary amyloidosis and ankylosing spondylitis, receiving genetic engineering biological therapy is presented.

Clinical case of a successful kidney transplantation in a patient with secondary amyloidosis and ankylosing spondylitis, receiving genetic engineering biological therapy is presented.

Relapsing polychondritis (RP) is a generalized progressive autoimmune inflammatory disease of the cartilaginous tissue, which leads to structural changes in the cartilage until its complete disappearance. To date, about 800 RP cases have been described in the world. The clinical manifestations of RP are diverse, which often complicates the early diagnosis of the disease. The most commonly used drugs to stop RP activity are glucocorticoids, the dose of which depends on the severity of its clinical manifestations, but there is no evidence for their effect on the progression of the process and the risk of relapse. The paper describes a clinical case of early diagnosis and successful treatment of the disease, which could prevent possible complications and disability in the patient.

The paper describes a clinical case of late diagnosis of malignant lung tumor with the development of skeletal and intracranial lymph node metastatic lesions. Right hip joint pain was the reason for seeking medical advice; coxitis was diagnosed. Weight loss, obvious blood inflammatory changes, and a long-term smoking history aim to find cancer. Further examination as multislice spiral computed tomography of the lungs and pelvic bones could establish a diagnosis.

Authors studied the dependence of nitrous oxide stable metabolites in blood serum and in urine in patients with psoriatic arthritis on the disease clinical peculiarities and their dynamics in the process of basic therapy. It was determined that the level of nitrous oxide stable metabolites was the supplementary criterion of pathological process activity and therapy effi cacy.

Objectives. To study clinical efficacy of therapy of prospidin (P) in patients with ankylosing spondylitis (AS). Material and methods. 93 patients with the definitive diagnosis of AS with signs of clinical laboratory activity were studied. 33 patients received therapy of Pr in doses of 200-300 mg per 5% glucose N 4 IV in the inpatient hospital. The supportive therapy included Pr in doses of 100-200 mg per week IM. 30 patients received methotrexate (MT) in doses of lOmg/week IM and 30 patients received nonsteroidal anti-inflammatory drugs (NSAID) (diclofenac natrii in doses 100 mg per os). The efficacy of treatment was evaluated by changing clinical laboratory indices. Clinical effects were evaluated and estimated every 1, 3, 6, 12 months. Results. The therapy of P in patients with AS provided fast and marked clinical effect within 2-3 weeks and during supportive therapy. In groups received MT and NSAID the above parameteres improved within 4 5 weeks, MT and NSAID have less clinical effects. P therapy reduced doses of NSAID. Side effects of P therapy were reversible and not severe. They led to discontinuation P therapy in 21,2%. Conclusion. P therapy has earlier and more evident clinical effects, then MT and NSAID therapy. Administration of P therapy allows to improve overall results of treatment in AS patients.