AIM:To evaluate the efficiency of using the vitamin and mineral complex (VMC) ALFAVIT Diabetes in the combination therapy of diabetic polyneuropathy (DPNP) in adolescents.SUBJECTS AND METHODS:A study group comprised 30 children with diabetic peripheral polyneuropathy, whose combination therapy included ALFAVIT Diabetes as one tablet t.i.d. for 2 months. A comparison group consisted of 20 adolescents with DPNP who did not take the complex. Before and 2 months after the study, the children's state was assessed from the data of a physical examination with mandatory blood pressure and pulse measurements and a neurological study, from carbohydrate (basal glycemia, glycemic variability, glycated hemoglobin) and lipid (total cholesterol and its fractions) metabolic parameters, and from the findings of electromyography (EMG).RESULTS:Incorporation of the VMC ALFAVIT Diabetes into the combination therapy contributed to the ameliorated clinical manifestations of DPNP. There were positive electrophysiological changes, as evidenced by EMG. The VMC ALFAVIT Diabetes showed good tolerability and caused no adverse reactions.CONCLUSION:The performed trials have indicated that it is expedient to use the VMC ALFAVIT Diabetes in adolescents with type 1 diabetes mellitus and DPNP.

The diabetes of 1 type at children and teenagers is a challenge. The beginning of illness at early age and threat of development of sharp and chronic complications already at young age cause search of the optimal methods of treatment of this heavy disease. In clause results of use of system of long monitoring гликемии (CGMS) and continuous hypodermic introduction of insulin (insulin pumps) in practical activities of children's doctorsendokrinology are presented. As a result of research opportunities помповой are shown to therapy and monitorings of a level гликемии in more safe and effective achievement of indemnification of a diabetes at children and teenagers.

Aim. To elucidate the role of diabetic nephropathy in pathogenesis of myo-cardial lesions in children with type 1 diabetes mellitus from the results of dopplerography of intrarenal vessels. Materials and methods. The study involved 39 children with DM1 (mean age 12,5?2,6) divided into 2 groups. Group 1 included 12 patients with subclinical diabetic lesions in the kidneys (hyperfiltration), group 2 and 3 comprised 21 and 6 patients with diabetic neph-ropathy (microalbuminuria 30?300 mg/day or proteinuria respectively). All patients under-went standard examination to evaluate cardiovascular and vegetative nervous function. Analysis of spectrograms obtained by dopplerography of intrarenal vessels included main renal artery (MRA), segmental (SA), interlobe (ILA), arch (AA), and interlobular (ILbA) arteries. Results. The study groups were not significantly different in terms of MRA, SA, AA, and ILA hemodynamics but, unlike healthy controls, showed a nonlinear decreasing gradient in vascular resistance from MRA toward peripheral vessels especially ILA and AA. Left ven-tricular hypertrophy with disturbed diastolic performance documented in 64% of the patients correlated with microalbuminuria (r=0,56, p

The use of an Amfit-0,2/10-01 apparatus generating low-intensity ultrahigh frequency (UHF) electromagnetic radiation improved efficiency of therapy of sick children. This treatment allowed to reduce the frequency of intake of anesthetics in the post-operative period, correct metabolic disorders in children with type 1 diabetes mellitus, reduce severity of diabetic nephropathy and polyneuropathy, prevent formation of fresh foci of lipoid necrobiosis. The results of the study indicate that the use of low-intensity UHF electromagnetic radiation may be recommended for more extensive introduction into practical clinical work of pediatric endocrinologists and surgeons.

The increase of morbidity with diabetes mellitus (DM) in children and adolescents during last years, and absence of adequate control of disease reveal the need of complex study of quality of life in these patients. The article presents the results of evaluation of quality of life rates, obtained with Russian versions of questionnaires PedsQL 4.0 Generic Core Scale and Diabetic Module in children and adolescents with diabetes type I, treated with different combinations of insulin drugs. The results showed that quality of life differs between group of healthy adolescents and patients with DM. There was correlative dependence between the level of glycated hemoglobin and parameter «school function» of quality of life. Administration of insulin analogs improves some indices of adolescents’ with DM quality of life. Estimation of it is one of the main criteria of treatment effectiveness.Key words: children, adolescents, insulin, diabetes type 1, quality of life.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(5):14-18)

The level of plasma fibronectin was determined in healthy newborns (45 plasma samples were examined in the control group) and in newborns with pyo-septic diseases (67 plasma samples were examined) by the immunoenzyme method (on the basis of the "sandwich" modification of the immunoenzyme analysis). Noticeable hypofibrinectinemia was observed in the infants with pyo-inflammatory diseases, particularly in cases of generalized forms. Combined modality etiopathogenetic therapy including i.v. plasma transfusion, did not exceed fibronectin deficiency in clinical convalescence of infants. Fibronectin deficiency is regarded as a risk factor of the development and generalization of pyo-inflammatory diseases.