The possibility of using domestic chromatographic columns for organic nitrate derivative drug analysis was studied. A considerable advantage of these columns is in their cost, which is rather low in comparison with the imported analogues. The research results proved that columns with sorbents of C18 type (Dyaspher 110S18, Dyasorb 13016T, Dyaspher 110S16) as well as columns with nitrite groups (Dyaspher 110nitril, Dyaspher 110C10CN) can be successfully used for the above mentioned purposes.

The influence of the various pharmaceutical factors on the release of active substances from matrix tablets based on interpolyelectrolyte complexes of a poly (methacrylic acid) and poly(ethylene glycol) was studied. By varying these factors, it is possible to control the drug release kinetics and create new medicinal forms with preset pharmacological properties. The most important factors are the polymer fraction in the composition and the character of interaction between the active substance and matrix components.