The superparamagnetic nanoparticles of magnetite citrate (SNMCs) consisting of nanospheres aggregates with the hydrodynamic diameter being between 15 to 35 nm with a magnetite core diameter of 3 to 12 nm, coated with of citrate anions was synthesized. A water 25% sol of SNMC was successfully tested as magnetic resonance imaging (MRI) contrast agent. The same 40% sol was then combined with Inox and used at regional magneto-thermo-chemotherapy (RMTCT) of Lewis lung carcinoma (LLC) and Ehrlich carcinoma (EC), in female C57Bl / 6j mice. In the early stages of carcinoma development, the proliferation centers of LLC and EC cells were visualized and, during treatment, they obtained a significant increase in the efficiency of regional magneto-thermo-chemo-therapy.

Particular applications in preclinical magnetic resonance imaging require the entire body of an animal to be imaged with sufficient quality. This is usually performed by combining regions scanned with small coils with high sensitivity or long scans using large coils with low sensitivity. Here, a metamaterial-inspired design employing a parallel array of wires operating on the principle of eigenmode hybridization was used to produce a small-animal imaging coil. The coil field distribution responsible for the coil field of view and sensitivity was simulated in an electromagnetic simulation package and the coil geometrical parameters were optimized for whole-body imaging. A prototype coil was then manufactured and assembled using brass telescopic tubes with copper plates as distributed capacitance. Its field distribution was measured experimentally using the B1+ mapping technique and was found to be in close correspondence with the simulated results. The coil field distribution was found to be suitable for large field of view small-animal imaging and the coil image quality was compared with a commercially available coil by whole-body scanning of living mice. Signal-to-noise measurements in living mice showed higher values than those of a commercially available coil with large receptive fields, and rivalled the performance of small receptive field and high-sensitivity coils. The coil was deemed to be suitable for some whole-body, small-animal preclinical applications.

Large field of view magnetic resonance imaging is often required during small animal imaging to cover the entire body of an animal. Large field of view imaging should nevertheless be performed with sufficient signal to noise ratio and resolution. A combination of large signal to noise ratio and high resolution is usually achieved via using small loop coils with small field of view, which is inapplicable in case whole animal or a large portion of its body needs to be imaged. Here, a metamaterial-inspired coil based on an array of parallel wires is employed to perform large field of view imaging. A number of mice are imaged in a 7 T preclinical magnetic resonance scanner. Properties of the resulting images are compared to the ones acquired with commercial coil designated for whole-body imaging as well as a with a commercial small loop antenna designated to provide high signal to noise ratio images in a limited area. The signal to noise ratio is compared between the coils in different tissues and on different distances from the metamaterial-inspired coil plane. The coil is found to provide signal to noise ratio a few times higher than the commercial coil in the optimal reception region and comparable signal to noise ratio off the optimal observation region. The metamaterial-inspired coil is also shown to provide rivaling signal to noise ratio in small field-of-view application, when compared to a small-region loop coil.

We present a new efficient method of incorporation of gadolinium chelates into polymeric shell surrounding liquid nanoparticles of perfluorotributylamine, which does not degrade the particles stability. The payload reaches ca. 105 Gd ions per nanoparticle giving large local concentration of contrast agent. The relaxivity of Gd-loaded nanoparticles estimated by magnetic resonance imaging at 7 T magnetic field is as high as 105–106 mM−1 s−1. These nanoparticles are promising for dual-mode imaging simultaneously on two nuclei 1H and 19F, thus enhancing the quality of visualization.

Citric-ferrite sol (CFS) has been synthesized and successfully tested as MRI negative contrast preparation for revealing primary tumors, and also invasions and metastases at the tumor relapses. Magnetohydrodynamic thermochemotherapy (MTC) by Cysplatin (CP), Mitoxantron (MX), Melphalan (MP) combined with CFS, which were carefully monitoring in vivo and quantified by an electronic detector, improved results of cancer treatment. At various stages of oncogenesis, MTC with CFS at a dose of 62 mg Fe/kg combined with chemotherapeutic drugs was performed at +48º C for 30 min. While such MTC, treatment of ~30 mm3 B 16 melanoma tumor by AC magnetic field led to tumor regression in female mice up to 40 %, and an increase of life span up to 300 % was achieved.