The study was undertaken to investigate the clinical, biochemical, electrocardiographic, echocardiographic correlations of lipomatosis of interatrial septum (atrial septum thickness more than 1 cm) and visualized epicardial fat. The prevalence of excessive body weight and abdominal obesity, atherogenic changes in the lipid profile were revealed in 87 patients. The range of atrial septum thickness was 11-17 mm, lipomatosis of interatrial septum was revealed in 85% of patients. The epicardial fat was present in 39 patients (44,8%). During Holter monitoring of ECG supraventricular arrhythmias were registrated more frequent in patients with lipomatosis of interatrial septum. The results of correlative analysis demonstrate correlation of atrial septum thickness in patients with lipomatosis with changes in carbohydrate and lipid metabolism, with left ventricle hyperthrophy and decreased left ventricular ejection fraction. Presence of epicardial fat correlates with abdominal obesity, diastolic dysfunction and hyperthrophy of left ventricle. The findings indicate that lipomatosis of interatrial septum and epicardial fat may serve as markers of metabolic syndrome.