A study of quality of life in patients with rheumatoid arthritis development of varying degrees of violations of the microflora of the large intestine and found that the development of disorders of the intestinal microflora is accompanied by a significant change in the quality of life of patients. In patients with varying degrees of violations of microbial gut microbiota observed decline in physical and psychological components of health. The lowest values of quality of life in patients fitted with the II degree of microbiological violations microbiota of the large intestine.

It is believed that the concentration of C‑reactive protein (CRP) significantly increases in acute forms of systemic lupus erythematosus (SLE). A moderate increase of CRP levels in patients with stable disease progression reflects the low‑grade chronic inflammation in the vascular wall and the development of subclinical atherosclerosis. The article presents data showing that increased CRP levels in SLE patients is not statistically related with disease activity and cardiovascular risk as well as the level of interleykin‑6. Patients with lupus nephritis have lower CRP concentration compared to patients without renal disease and CRP concentration depends on proteinuria and hypoalbuminemia.

The aim of the investigation is to assess clinical effect of local (intra-articular) application of autologous platelet-enriched plasma (PEP) in treating gonarthrosis. Materials and methods. Clinical observation of 83 women with gonarthrosis was performed within 3 months. Within 3 weeks the patients were receiving PEP intra-articular injections of 5 ml twice a week. Results. In intra-articular PEP administration in patients with gonarthrosis, the change of knee joint functional state occurs depending on the severity of osteoarthrosis, the most significant change in the early stage and almost absent change in severe diseases (complicated by synovitis). In typical gonarthrosis of II-III radiological stages, the positive effect is short-term and observed in early one-month observation period.

The aim of the investigation is to assess clinical effect of local (intra-articular) application of autologous platelet-enriched plasma (PEP) in treating gonarthrosis.Materials and methods. Clinical observation of 83 women with gonarthrosis was performed within 3 months. Within 3 weeks the patients were receiving PEP intra-articular injections of 5 ml twice a week.Results. In intra-articular PEP administration in patients with gonarthrosis, the change of knee joint functional state occurs depending on the severity of osteoarthrosis, the most significant change - in the early stage and almost absent change in severe diseases (complicated by synovitis). In typical gonarthrosis of II-III radiological stages, the positive effect is short-term and observed in early one-month observation period.