Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites. Impaza, NO donors, activators of NO-synthase, antioxidants, and antihypertensive preparations produced endothelium-protective effect of different degree.

The comparative investigation of the endothelioand cardio protective effects of a preparation manufactured by Pharmstandard (Kursk) has been carried out in modeling the L-NAME-induced nitrogen oxide deficiency. Kardionat in a doze of 80 mg/kg equally prevents the development of L-NAME-induced endothelial dysfunction, the increase in adrenoreactivity and the decrease in the myocardial reserve.

Studying of a condition of a vascular wall and search of opportunities of purposeful treatment endothelial dysfunction (ED) is the important clinic-experimental problem. One of the major factors leading to ED is reduction in stability endothelial NO-синтазы (eNOS). One of the important points of the appendix of therapeutic influence at ED is restoration of deficiency nitrice oxide (NO). However now there are no preparations for specific correction ED. The purpose of the present research was the analysis of literary data about influence of different medical products on a functional condition endothelium and studying endothelioprotective effects of a new class of the medical products positioned as a class endotheliotropic additives with recommendations to obligatory purpose-by patients with cardiovascular diseases.

Now the big attention in a medical practice is given amino acids L-arginine. At laboratory animals at modelling endothelial dysfunctions by introduction inhibitor NO-syntase L-NAME activization endothelioprotective effects amlodipine and indapamide is revealed at combination their introduction с L-arginine. This position proves to be true generalizing settlement parameters of functional tests on vascular reactance, most significant additive effect was showed in group indapamide + L-arginine.

The factor of endothelial dysfunction offered by us (FED), allows to estimate a degree of endothelial dysfunction at modelling deficiency nitrice oxide, that correlates with biochemical (depression of the contents nitrite-ions and expressions eNOS) and morphological (augmentation of diameter of cardiomyocytes, a spastic stricture, a thickening of a muscular layer and a desorientation of endotheliocytes of renal arterioles) markers.