In the present work the renin-angiotensin system gene polymorphisms REN (I9–83G > A), AGT (M235T), AGTR1 (1166A > C), AGTR2 (3123C > A), BKR2 (–58T > C) in pregnant women with preeclampsia, women with physiological pregnancy, healthy donors have been studied using allele-specific hybridization on the biochip. There were no statistically significant differences in genotypes distribution and allele frequencies of any genes between pre-eclampsia patients and women with normal pregnancy or donors (p > 0.05). However, it was shown that C/C genotype for the AGTR2 gene is a risk factor for preeclampsia in women with chronic pyelonephritis. In addition, accuracy of predicting the risk of pre-eclampsia based on the pyelonephritis availability and genotypes for genes AGTR1, AGTR2, BKR2 was 69 % using a logistic regression method
Andrey S. Glotov合作论文数Laboratory of biobanking and genome medicineRussia, St Petersburg University;Research Institute of Obstetrics and Gynecology named after D.O. Ott6
Баранов Владислав Сергеевич合作论文数5Marina Sabirovna Zainulina合作论文数4Иващенко Татьяна Эдуардовна合作论文数3Канаева Мария Дмитриевна合作论文数3
Roma Kurilov合作论文数Div Appl Bioinformat, DKFZ3
Oleg Glotov合作论文数Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency;Department of Genetics and Biotechnology, St Petersburg University3Махрова Ирина Александровна合作论文数2Образцова Галина Игоревна合作论文数2Лившиц Людмила Аврамовна合作论文数1Похитун Марина Васильевна合作论文数1Мертил Мертил合作论文数1Татарский Павел Феликсович合作论文数1Бикмуллина Дина Рустемовна合作论文数1Марочкина Екатерина Юрьевна合作论文数1Двоеглазова Мария Олеговна合作论文数1Храмеева Екатерина Евгеньевна合作论文数1Диткина Екатерина Юрьевна合作论文数1Корсун Мария Михайловна合作论文数1багрий мария андреевна合作论文数1Dina Rustemovna Bicmullina合作论文数1Maria D Kanaeva合作论文数1Насыхова Юлия Алмазовна合作论文数1Irina V Tarkovskaia合作论文数1Baranov Vladislav S合作论文数1
