The data on the expressed toxic effect of ethanol in dose DL 50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statistic analysis it was proved, that new chelate zinc (2,8,9-trihydrozincatrane) in the protective dose of 4 mg/kg under conditions of the acute ethanol poisoning reduces the severity of oxidative stress and normalizes indicators of antioxidant system.

It was established, that ethanol in the dose of 12 g/kg in experimental animals (white non-inbred male rats) had. expressed damaging effect on the liver, that is shown in statistically significant increase of activity of hepatic enzymes (alanine aminotransferase, alkaline phosphatase), hypoglycemia, development of albuminous and. hydropic degeneration. It is proved, that application of new chelate zinc (2,8,9-trigidrotsinkatrane) in experimental correction of acute ethanol poisoning promotes reduction of metabolic and morphological derangements.

At the study of women of Buryat population with normal pregnancy in comparison with pregnant women of Russian population increased content of ferum level in all trimesters is discovered. At the threat of miscarriage in the group of women of Buryat population higher concentration of ferum and reduced level of zinc reduced are determined in the 1st and 2nd trimesters.

We examined. 111 adolescent boys, 83 of them. had. hypothalamic puberty syndrome. The tendency to forming of the oxidative stress was shown in examined, patients with hypothalamic puberty syndrome.

The research presents the study results of antioxidant protection of enzymatic link, particularly the content of oxidized and reduced glutathione and superoxide dismutase activity, glutathione peroxidase and glycosyl-transferases in men ejaculate in chronic monotrichomonal infection. Statistically significant activity increase of superoxide dismutase and decrease of reduced form glutathione level were identified in the male group after the undergone treatment.

In this article the results of gynecological morbidity and lipid peroxidation investigation in girls adolescents, whose mothers were employed at chemical production, are presented. The relationship between increase of neuro-endocrine syndromes frequency, hyperlipiperoxidation in adolescents and their mothers working environment before and during pregnancy is found out.

The comparative analysis of lipid peroxidation and antioxidant defense in 11 patients with diabetes mellitus of the 1st type and patospermia and in 19 normospermic men with diabetes mellitus type 1 was performed. The increase of lipid oxidation, Upoperoxidation activation on the stage of malonic dialdehyde formation and decrease of common antioxidant activity of blood serum were shown in patients with diabetes mellitus type 1 and patospermia. At the same time the superoxide dismutase activity and glutathione system stabilization simultaneously with increase of axidation processes intensity were revealed in these patients.

In the big industrial center of Eastern Siberia with high level of chemical pollution, as Irkutsk, which is situated in the region with strongly-pronounced continental climate essential arterial hypertension in adolescents is characterized by imsbalance in macro-and microelemnts that is combined with distur-bances in psychoemotional status.