This article shows the modern views of the resistance of microorganisms to disinfectants and mechanisms of its formation. Different versions of the impact of subbactericidal concentrations of disinfectants, which can be replicated in laboratory conditions. The results of experiments on the formation of induced acquired resistance by the test strain of E.coli to disinfectants from the group of quaternary ammonium compounds (QAC) in the laboratory. The estimation of changes in the microbiological properties, sensitivity to antibiotics and disinfectants, performed electronic microscopy of bacteria in the process of resistance appearance. Any evidence of the possibility of microbial resistance to QAC-containing disinfectants under the influence of repeated impacts of subbactercidal concentrations in laboratory conditions, the time frame of its appearance.

Epidemiological and microbiological peculiarities of hospital purulo-septic infections of neonates are given in the article. The role of coagulase-negative staphylococcus in etiology of these infections is shown. Wide spectrum and specific variety of staphylococcus are demonstrated. Resistance of hospital strains of coagulase-negative staphylococcus towards antibacterial preparation is studied. Comparative characteristics of adhesiveness and decolonial capacity of different staphylococcus is given.