Abstract To develop bone implants using Ti materials, the issue of creating bioactive coatings that ensure their rapid engraftment to the bone is acute. The rate of fusion of Ti implants with bone tissue is significantly influenced by the degree of modification of the coating surface based on changes in the relief, chemical composition of the surface layer and mechanical characteristics of the implant. The structure and mechanical properties of a Ti-based composite with TiO2/Ag/HAp coating of an island-like type were investigated, which showed high bioactive properties of the sample. The paper shows that the application of an island-like coating on the Ti surface with a height difference of 0.7 microns does not lead to a deterioration in the mechanical characteristics of the Ti implant, and the hardness increases by 15%.

Previously unknown bis-α-hydroxyphosphine oxides were synthesized by addition of secondary phosphine oxides to dicarbonyl compounds obtained by binding two salicylaldehyde molecules through ether-type spacers. The resulting compounds are of interest as potential biologically active substances, complexing agents, and initial building blocks in the synthesis of macrocyclic compounds with pendant phosphorus-containing substituents.

Разработана методика синтеза суперпарамагнитных наночастиц магнетита в порах мезопористых кремнеземов МСМ-41. Изучена зависимость магнитных свойств нанокомпозитов МСМ-41/Fe3O4 от радиуса пор синтезированного кремнезема МСМ-41.

The important stage of the development of smart material for the target drug delivery is the construction of the magnetic part of this material, including mesoporous silica and magnetic nanoparticles (Fe3O4or Fe0). Such a systemwill allow carry outmagnetic decapsulation (excretion) of drug from smart material using the magnetic field of a given value in the right place of the body. The paper considers the features of synthesis mesoporous silica MCM-41 with various pore diameter (33-51 Å) and synthesis of superparamagnetic nanoparticles of magnetite or metallic iron in the pores of mesoporous silica. The dependence of magnetic properties of nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 from the pore diameters of MCM-41 templates is studied. It was found that the matrix has a decisive influence on the content of iron or magnetite nanoparticles. The saturation magnetization of the material increases with increasing pore size of the mesoporous matrix. Nanocomposites MCM-41/Fe0 and MCM-41/Fe3O4 exhibit superparamagnetism, that allows them to be used as a magnetic material for targeted drug delivery.

A procedure for the synthesis of superparamagnetic magnetite nanoparticles in pores of mesoporous silica MSM-41 was developed. The dependence of magnetic properties of MSM-41/Fe3O4 nanocomposites on the pore radius of the synthesized silica MSM was studied.

Conditions for the preparation of Fe3O4@SiO2 core-shell nanoparticles aggregatively stable in aqueous solutions were determined.

The paper describes magnetic core-shell nanoparticles (Fe 3 O 4 /SiO 2 ) synthesis that is an important stage of the manufacturing of smart material for targeted drug delivery based on the construction of the composite system mesoporous silica (MCM-41) – magnetite nanoparticles (Fe 3 O 4 ) – immune cells (macrophages) for targeted drug delivery. The synthetic procedure for the fabrication of core-shell nanoparticles is modified in order to produce core-shell nanoparticles of the composition Fe 3 O 4 @SiO 2 in the superparamagnetic state. This is confirmed by the studies of phase composition and magnetic properties of this material. The dependence of the particles size of magnetite sol on initial concentration of iron chlorides is established. The conditions for the fabrication of core-shell Fe 3 O 4 @SiO 2 particles that are aggregatively stable in water are determined. Structural investigations of the samples demonstrate that the sizes of Fe 3 O 4 @SiO 2 particles lie in the range 30 50 nm.

Mesoporous silica nanoparticles (MSNs) impregnated with zero-valent Fe (Fe(0) @ MCM-41) represent an attractive nanocarrier system for drug delivery into tumor cells. The major goal of this work was to assess whether MSNs can penetrate the blood-brain barrier in a glioblastoma rat model. Synthesized MSNs nanomaterials were characterized by energy dispersive X-ray spectroscopy, measurements of X-ray diffraction, scanning electron microscopy and Mössbauer spectroscopy. For the detection of the MSNs by MR and for biodistribution studies MSNs were labeled with zero-valent Fe. Subsequent magnetometry and nonlinear-longitudinal-response- M 2 (NLR- M 2 ) measurements confirmed the MR negative contrast enhancement properties of the nanoparticles. After incubation of different tumor (C6 glioma, U87 glioma, K562 erythroleukemia, HeLa cervix carcinoma) and normal cells such as fibroblasts and peripheral blood mononuclear cells (PBMCs) MSNs rapidly get internalized into the cytosol. Intracellular residing MSNs result in an enhanced cytotoxicity as Fe(0) @ MCM-41 promote the reactive oxygen species production. MRI and histological studies indicated an accumulation of intravenously injected Fe(0) @ MCM-41 MSNs in orthotopic C6 glioma model. Biodistribution studies with measurements of second harmonic of magnetization demonstrated an increased and dose-dependent retention of MSNs in tumor tissues. Taken together, this study demonstrates that MSNs can enter the blood-brain barrier and accumulate in tumorous tissues.