In the early terms of pregnancy anti-infectious protection provides by NK-cells of deciduas. The distribution of immunocompetent cells in the deciduas of women at 6-8 week of gestation and different infections has been studied by immunohisyochemical method. The quantity of NK-cells with CD56 +/- CD16+ CD3- phenotype significant decreased at mycoplasmas infection. Clamidiosis correlated with 2-folder increasing of CD56+/- CD16+ CD3- cells. The quantity of CD56++ CD16- CD3- cells in the deciduas didn't differ between compared groups. The revealed changes in local immunity are accompanied by infringement of gestational transformation, especially under clamidiosis.

The composition and distribution of immunocompetent cells in human decidua basalis at 6-8 weeks of pregnancy was studied immunonohistochemically under normal conditions (control group) and in infection with different mycoplasma species (microbial number> 104 CFU). In all the groups studied, monocytes were most numerous cells; large granular lymphocytes (phenotype: CD56++CD16-CD3), macrophages (CD68+) and immunonegative lymphocytes were observed in equal proportions; the least numerous populations were those of NK-cells (CD56+/-CD16+), plasmocytes and granulocytes. No statistically significant differences were found between the content of these cells in all the investigated groups. The data obtained suggest that mycoplasma infection even characterized by high microbial number, does not cause significant changes in the composition of decidua basalis cellular infiltrate.

Objective: to evaluate morphological changes in the utero-placental region in the first trimester of pregnancy complicated with urogenital infection. Subjects: 90 women at gestational age 42-56 days, who planned abort for non-medical reasons are divided into 4 groups: 1st group 16 pregnant women who had mycoplasmal colpitis and receiving specific treatment, 2nd group 20 pregnant women who had nonspecific colpitis and received nonspecific therapy, third group of 31 pregnant women with asymptomatic mycoplasma infection, group 4 66 healthy pregnant women. Methods: clinical and history data studies; bacterioscopy exfoliative smears vaginal portion of the cervix; the identification of urogenital mycoplasma PCR, morphological study abortion material. Results: the morphological study abortion material show that the structure of the utero-placental region corresponded to gestation age. Specific volumes of stromal decidua basalis and decidua parietalis in the group with mycoplasma infection was half that of the control group and amounted to respectively 7.5, 8.0 and 17.3. On the other hand the content of decidua cells in the experimental group exceeded performance in the control group 23.0 and the maximum value 31.1 reached in the group of pregnant women with asymptomatic carriage of mycoplasmas (p=0,02) necrotic changes in the decidual tissue were observed equally often in all groups. Conclusion: all founded changes in the overall fit in the concept of compensatory-adaptive reactions inresponse tj the pathogenic effects of urogenital mycoplasmas. These changes are adaptive in nature and do not prevent the progression of pregnancy. Mycoplasmal colpitis antimicrobial therapy leads to normalization of the structural organization of the utero placental region.