AIM:Determine species composition and persistent properties of Candida genus fungi isolated from various biotopes of the human organism during infectious-inflammation diseases and intestine dysbiosis.MATERIALS AND METHODS:152 Candida genus fungi were isolated and identified from individuals with dysbioses and patients with infectious-inflammation diseases. Antilactoferrin and sIgA-protease activity of isolates was determined by enzyme immunoassay. RESULTS. C. albicans strain was shown to be the dominant species isolated from all the studied biotopes. Wide prevalence of the studied properties in Candida genus fungi and their dependence on species membership, isolation biotope, infectious process form, degree ofdysbiotic disorders in intestine was established.CONCLUSION:The data obtained expand the understanding of biological properties of Candida genus fungi that facilitate their prolonged survival in host organism.

Aim. Define the mutual influence of Lactobacillus sp., isolated of the veterinary probiotics, and opportunistic microorganisms, isolated by animals with intestinal dysbiosis, on the persistent potential. Materials and methods. 24 strains of opportunistic microorganisms: lactosonegative hemolytic E. coli, S. aureus, K. pneumoniae, C. albicans, isolated from the intestines of animals with dysbiosis. Laktoferon ( L. acidophilus ), Laktoamilovorin ( L. amylovorus ), Laktobifadol ( L. acidophilus ) isolated from veterinary probiotics. Isolation and identification of microorganisms were carried out by common methods based on morphological, tinctorial, cultural and biochemical properties. Factors of persistence (ALA, ALfA) were studied by foto-nefelometric and enzyme immunoassays methods before and after mutual influence of microorganisms in a liquid medium. Results. Lactobacillus sp., isolated from probiotics, have different effects on the persistent signs of opportunistic microorganisms. The most effective among all selected probiotics were Laktoamilovorin, reducing the ALfA and the ALA in most species studied microorganisms. Whereas the opportunistic microorganisms differently affect (reduce, increase, indifferent effect) on the ALfA and do not significantly change the ALA of Lactobacillus sp., slightly increasing the ALfA of L. amylovorus. Conclusion. The data obtained can be used in veterinary medicine to correct dysbiotic disorders in animals with the most effective probiotics, selected under the control of persistent characteristics.

The paper presents the results of studying the anti-lactoferrin and sIgA-protease activities of Candida strains isolated in varying human intestinal dysbiosis. Thirty-eight Candida strains were isolated from patients with dysbiosis. The isolated strains were found to have anti-lactoferrin and sIgA-protease activities. The wide spread of the examined properties of Candida and their dependence on its species and the degree of dysbiotic disorders were established. The findings gain more insight into the range of biological properties in the fungi Candida, which contribute to the long-term survival of their host with microenvironmental abnormalities.