The content of shikimic acid in the vegetative parts of a number of plants growing in the Altai Territory has been studied. The greatest content of shikimic acid (about 1.5%) was found in the coniferous needles of Scots pine. Shikimic acid accumulated in buckwheat cells cultivated in vitro on glyphosate-containing medium. The best results were obtained with buckwheat explants cultivated in vitro on Murashige and Skoog nutrient medium in the presence of 0.5 × 10−3 mg/L of glyphosate.

Описан метод синтеза N'-{N-[3-оксо-20(29)-лупен-28-оил]-9-аминононаноил}-3-амино-3-фенилпропионовой кислоты - соединения, обладающего иммуностимулирующей и антивирусной активностью. Соединение получено присоединением к бетулоновой кислоте метилового эфира N-(9-аминононаноил)-3-амино-3-фенилпропионовой кислоты.

A method for synthesizing N'-{N-[3-oxo-20(29)-lupen-28-oyl]-9-aminononanoyl}-3-amino-3-phenylpropionic acid, a compound that exhibited immunostimulating and antiviral activities, by adding the methyl ester of N-(9-aminononanoyl)-3-amino-3-phenylpropionic acid to betulonic acid was described.

A high-pressure liquid chromatography-mass spectroscopy (HPLC-MS) study of the product composition from the catalytic hydrogenolysis of 2,4,6,8,10,12-hexabenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (HBIW) and 4,10-dibenzyl-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (DBTA) was undertaken. The hydrogenolysis of HBIW is observed in all possible directions. Debenzylation of DBTA in formic acid results in forming the mixture of 4,10-diformyl-2,6,8,12tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (DFTA), 4-formyl-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (FTA), and 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TA), the contents of which depend on the CHOOH concentration. In aqueous solutions of formic acid the process is complicated by hydrolysis of the amide groups. Some of the hydrolysis products keep the structure of 2,4,6,8,10,12-hexaazaisowurtzitane. Debenzylation of DBTA in mixtures of formic/acetic, formic/propionic, or formic/iso-butyric acids leads to the same mixed products. The procedure of palladium catalyst reuse in the two-stage reductive debenzylation of HBIW was developed and is presented.

A method for improving the quality and increasing the yield of 2,7-dihydroxyfluorenone by using a rotor– stator apparatus in the process technology is described. The results can be used in the manufacturing of tilorone.

The paper contains information on a method for improving the quality and increasing the yield of 2,7-dihydroxyfluorenone by using a rotary-pulsed apparatus in the process technology. The results obtained can be used in the manufacturing of Tilorone.

The debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetra-cyclo[5.5.0.03,11.05,9]dodecane by catalytic hydrogenolysis in a mixture of HCOOH with other RCOOH (R = Me, Et, Pri) is accompanied by the N-formylation of the liberated secondary amino groups. The alkaline hydrolysis of the obtained products makes it possible to remove the formyl groups with the retention of the acetyl groups.