Аnalysis of 491 cases anaphylactic shock (from them 263 cases of a medicinal shock) is lead. The reasons were drugs (non-steroidal anti-inflammatory drugs, local anesthetics, antibiotics hymenoptera sting allergy, food). The clinic, urgent therapy is described. With view of preventive maintenance it is necessary to use rationally medical products, to avoid polipragmaziya, carefully to collect the allergic and pharmacological anamnesis.

Summary With the aim to evaluate the prevalence of latex allergy in healthcare workers, conducted was a questionnaire screening of 420 people who have professional contact with different products composed of or containing proteins of natural latex. An immunological study was carried out in 41 healthcare workers. An elevated Ig E level was found in 68,3% of health care workers, mostly in paramedical personnel. The results of this study need to be used for fu rther and more detailed evaluation of the peculiarities of the clinical course of allergic diseases caused by latex in order to establish and implement a complex of diagnostic and prophylactic measures.

The aim of the study was to assess efficacy and safety of 24-month treatment with Seretide (salmeterol / fluticasone propionate, 100 / 1 000 mcg daily) or Flixotide (fluticasone propionate, 1 000 mcg daily) in 105 steroid-dependent asthma patients aged 18 to 60 yrs who had received oral steroids for at least 6 months but not longer than 10 years. Methods. The study was comparative, randomized, multicentre, open in parallel groups (15 visits with 2-week intervals). Reduction of oral steroid doses started at the 3-rd visit. Results. In spite of the continual treatment with oral steroids patients did not reach asthma control. After 6-month therapy with fluticasone propionate or salmeterol / fluticasone propionate the maintaining dose of prednisolone was 6 times lower in comparison with baseline. Moreover, oral steroids were abolished in each second patient receiving Seretide and each third patient receiving Flixotide. The asthma control and quality of life significantly increased. Conclusion. The therapy with fluticasone propionate or salmeterol / fluticasone propionate allows to reduce doses of oral steroids and to cease oral steroids in most causes. Moreover, the patients can maintain good asthma control.