Analysis of functional tear production indices in patients with Grave's disease and thyroid eye disease confirmed lacrimal gland involvement in inflammatory autoimmune process. Close direct correlation was found between tear production and main disease characteristics - severity and activity.
Increase of lacrimal gland (LG) volume was revealed in 1/3 of patients with thyroid eye disease (TED) using visualization methods. Authors show morphological data confirming development of autoimmune process in LG in TED, biopsy samples were studied within 6 hours after exitus. Specific histomorphological characteristics were analysed considering dystrophic and degenerative changes in LG tissue. Quantitative assessment of fibrosis and vascularization extent is determined using fibrosis and vascularization index.
The authors studied the role of antibodies to tireoperoksidaze when autoimmune orbitopathy in patients with Graves disease. It is shown that the presence at the TPO from HIV-positive patients with autoimmune thyroid closely correlates with higher rank the severity and intensity (amplitude) autoimmune inflammation in orbit. Findings allowed authors to ascribe the AL to SLIP risk factors increase the severity and activity of autoimmune orbitopathy in patients with Graves disease.
The authors conducted a comparative analysis of clinical manifestations of endocrine orbitopathy in patients with Graves disease, depending on whether the presence of antibodies to tireoperoksidaze and their absence. The paper presents direct evidence to show that the persistence of autoantibodies to tireoperoksidaze endocrine orbitopathy affecting clinical manifestations. The Group of patients living with antibodies to SLIP more expressed above proptosis, eyelid edema and oculomotor disorders. Clinical evidence substantiated mul′tispiral′ computed tomography.
