Background: To compare different surgical correction methods of vesico-ureteric reflux in children using both open surgery and endoluminal (intraluminal) treatment options of this pathology. Patients and methods: 166 patients aged from 4 months to 13 were examined and treated. All children underwent X-ray urological examination through cystography and ultrasound examination of kidneys and urocyst. Cohen's operation, STING procedure involving endoscopic injection of bulking agents was performed. Treatment results were assessed 6 months later through control cystography. Conclusion: Endoscopic correction of vesico-ureteric reflux is an effective and minimally invasive treatment method for this pathology. Maximum treatment effect after biodegradable bulking agents application should be expected in younger age group. Treatment rates of endoluminal correction of vesico-ureteric reflux with the use of sterile viscous gel as a fixing agent are higher than with the use of bovine collagen.

The one of the most common defects of the ureter-vesical segment in children is the condition, leading to a disorder of obturative function of this segment. Complications of vesicoureteral reflux include continuously recurrent pyelonephritis, reflux nephropathy. In this regard, the choice of the optimal treatment strategy based on minimal invasion is considered as one of the priorities of pediatric urology. The article presents the data obtained during the treatment of VUR in children of different ages in the Clinic of Reproductive Health FSBSI SCCH. A comparative evaluation of the results of endoscopic correction of vesicoureteral reflux depending on the kind of the bulking agent was performed. It was found that the use of endocorrection of reflux is highly effective surgical procedure, with the high number of positive results against the background of use of bulking agent "vantris". The study discriminates a group of patients with vesicoureteral reflux, intractable for endoscopic correction with cystoscopically normal structure of the orifices that allows to refer this method to the initial stage of treatment of the disease.

Aim: The purpose of the study was to evaluate the endocrine profile condition in adolescent girls with abnormal uterine bleeding. Patients and methods: The participants of the study were 110 adolescent girls in the age between 11 and 15 years taken to hospital by emergency indication in the period between 2010–2013 years with dysfunctional uterine bleeding for the term from 3 to 48 days. In the first day of hospitalization before starting the hormonal therapy all patients underwent the physical examination, ultrasonic examination of pelvic organs and endocrine profile assessment. Concentration of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and the levels of mammotropic hormone, thyrotropic hormone, estradiol, progesterone and testosterone in their blood were determined. Besides that physicians assessed the complete blood count indices: hemoglobin concentration, erythrocyte number and hematocrits. Results: It was determined that the predisposing causes of abnormal uterine bleeding development in adolescents: high somatic pathology frequency, abnormalities of neuroendocrinal system and menstrual cycle. Gynecological pathology in adolescents is represented by significant disorders of menstrual function establishment expressed in the later beginning of menstruation, its intensity and duration. The authors also note the higher frequency of inflammatory diseases such as adnexitis, edeitis, vulvovaginitis and coleitis in comparison with the control group (37.3 and 30%, respectively). Another tendency was observed while studying the endocrine profile: in patients with hyperestrogenism the normal or increased content of FSH at the normal or lowered LH concentration is observed. At the same time, in patients with hypestrogenism FSH concentration at the lower limits of the age group is lowered, while LH concentration is lowered or normal. Conclusion: Abnormal uterine bleeding in adolescents in the most cases is developing in the setting of relative hyper- or hypestrogenism and the clinical presentation of the condition depends on this indicator.

Background: To compare different surgical correction methods of vesico-ureteric reflux in children using both open surgery and endoluminal (intraluminal) treatment options of this pathology. Patients and methods: 166 patients aged from 4 months to 13 were examined and treated. All children underwent X-ray urological examination through cystography and ultrasound examination of kidneys and urocyst. Cohen's operation, STING procedure involving endoscopic injection of bulking agents was performed. Treatment results were assessed 6 months later through control cystography. Conclusion: Endoscopic correction of vesico-ureteric reflux is an effective and minimally invasive treatment method for this pathology. Maximum treatment effect after biodegradable bulking agents application should be expected in younger age group. Treatment rates of endoluminal correction of vesico-ureteric reflux with the use of sterile viscous gel as a fixing agent are higher than with the use of bovine collagen.

Aim: The purpose of the study was to evaluate the endocrine profile condition in adolescent girls with abnormal uterine bleeding. Patients and methods: The participants of the study were 110 adolescent girls in the age between 11 and 15 years taken to hospital by emergency indication in the period between 2010–2013 years with dysfunctional uterine bleeding for the term from 3 to 48 days. In the first day of hospitalization before starting the hormonal therapy all patients underwent the physical examination, ultrasonic examination of pelvic organs and endocrine profile assessment. Concentration of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and the levels of mammotropic hormone, thyrotropic hormone, estradiol, progesterone and testosterone in their blood were determined. Besides that physicians assessed the complete blood count indices: hemoglobin concentration, erythrocyte number and hematocrits. Results: It was determined that the predisposing causes of abnormal uterine bleeding development in adolescents: high somatic pathology frequency, abnormalities of neuroendocrinal system and menstrual cycle. Gynecological pathology in adolescents is represented by significant disorders of menstrual function establishment expressed in the later beginning of menstruation, its intensity and duration. The authors also note the higher frequency of inflammatory diseases such as adnexitis, edeitis, vulvovaginitis and coleitis in comparison with the control group (37.3 and 30%, respectively). Another tendency was observed while studying the endocrine profile: in patients with hyperestrogenism the normal or increased content of FSH at the normal or lowered LH concentration is observed. At the same time, in patients with hypestrogenism FSH concentration at the lower limits of the age group is lowered, while LH concentration is lowered or normal. Conclusion: Abnormal uterine bleeding in adolescents in the most cases is developing in the setting of relative hyper- or hypestrogenism and the clinical presentation of the condition depends on this indicator.